Article
Cell Biology
Jizhong Zhao, Hongmei Hu, Hongling Zhou, Jingwen Zhang, Li Wang, Rui Wang
Summary: In this study, a controllable gene editing tool was developed using boronated gRNA, which can regulate the binding of gRNA molecules with Cas9 endonuclease or target genes. The restoration of gene editing ability was achieved by treating the boronated gRNA with H2O2. This approach complements the light approach and displays great potential for application.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Oncology
Mariko Ishibashi, Rimpei Morita, Hideto Tamura
Summary: Multiple myeloma is an incurable hematological malignancy characterized by abnormal plasma cells. The review focuses on the signaling lymphocytic activation molecule family receptors and their biological functions in MM, highlighting the potential of novel immunotherapies for relapse prevention.
Review
Immunology
Yevgeniya Gartshteyn, Anca D. Askanase, Adam Mor
Summary: T cell activation relies on signals integration from T cell receptor and co-receptors, with SLAM-SAP signaling playing a crucial role in T cell immunity, where balanced signaling is crucial for immune health.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dan Tomomasa, Claire Booth, Jack J. Bleesing, Takeshi Isoda, Chie Kobayashi, Kazutoshi Koike, Takeshi Taketani, Akihisa Sawada, Akihiro Tamura, Rebecca A. Marsh, Tomohiro Morio, Andrew R. Gennery, Hirokazu Kanegane
Summary: This study compared the prognosis of symptomatic probands and affected siblings with XLP1, and found that early HCT improves the prognosis of asymptomatic XLP1 patients.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel C. Schultz, Li Pan, Tiffany Wang, Conner Booker, Iram Hyder, Laura Hanold, Garret Rubin, Yousong Ding, Jiayuh Lin, Chenglong Li
Summary: In the past 25 years, efforts have been made to develop small molecule interleukin-6 (IL-6) signaling inhibitors, but none have been approved. This study used a structure-based drug design approach and carbohydrate building blocks to synthesize novel IL-6 signaling inhibitors targeting glycoprotein 130 (gp130). LS-TG-2P and LS-TF-3P were identified as promising lead compounds with preferential activity against the IL-6 signaling pathway. These compounds show potential for further development as IL-6 signaling inhibitors.
Article
Agriculture, Dairy & Animal Science
Haofei Song, Jima Quan, Chang Li, Wan Liang, Lan Zhang, Shuangshuang Wang, Hongyu Lu, Keli Yang, Danna Zhou, Peng Li, Yongxiang Tian
Summary: In this study, we found that overexpression of the SLAMF1 gene significantly inhibited PRRSV replication and reduced the levels of key signaling pathways and inflammatory factors. On the other hand, knockdown of the SLAMF1 gene enhanced PRRSV replication and the levels of key signaling pathways and inflammatory factors.
Article
Infectious Diseases
Youjia Zhong, Chiung-Hui Huang, Win Mar Soe, Koon Wing Chan, Mas Suhaila Isa, Jianyi Soh, Mark Yap, Paul Anthony MacAry, Yu-Lung Lau, Louis Yi Ann Chai, Lynette Pei-Chi Shek, Bee Wah Lee
Summary: These two Asian siblings have X-linked inhibitor of apoptosis deficiency which is caused by dysfunction in the nucleotide binding and oligomerization domain receptor pathway. They presented with Epstein-Barr virus disease and hemophagocytic lymphohistiocytosis.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Medicine, General & Internal
Yanchun Wang, Yan Wang, Weimin Lu, Lvyan Tao, Yang Xiao, Yuantao Zhou, Xiaoli He, Yu Zhang, Li Li
Summary: This study discovered that a mutation in the SH2D1A gene caused structural and functional changes in the SAP protein, leading to XLP-1. The PI3K-AKT-mTOR signaling pathway may play a role in the pathogenesis of XLP-1.
Article
Plant Sciences
Shu-Fang Huang, Yu-Lun Wang, Jih-Jung Chen, Yaw-Bin Huang, Shun-Ban Tai, Chih-Ling Chung, Chun-Lin Chen
Summary: The study demonstrates that Garcimultiflorone K (GMK) extracted from Garcinia multiflora inhibits TGF-beta signaling in hepatocellular carcinoma cells, attenuating metastasis and the disease-promoting effects of epithelial-mesenchymal transition (EMT). GMK was found to suppress TGF-beta-induced cellular responses such as Smad protein phosphorylation, cell migration, and extracellular matrix production.
Article
Oncology
Regina J. Lin, Andrew R. Nager, Spencer Park, Janette Sutton, Cecilia Lay, Zea Melton, Yi Zhang, Bijan Boldajipour, Thomas J. Van Blarcom, Siler H. Panowski, Barbra J. Sasu, Javier Chaparro-Riggers
Summary: Engineering iTurboCAR T cells allows for flexible control of cellular phenotype and function, leading to improved antitumor efficacy while minimizing viral cargo footprint.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Veronika Ecker, Lisa Brandmeier, Martina Stumpf, Piero Giansanti, Aida Varela Moreira, Lisa Pfeuffer, Marcel H. . A. M. Fens, Junyan Lu, Bernhard Kuster, Thomas Engleitner, Simon Heidegger, Roland Rad, Ingo Ringshausen, Thorsten Zenz, Clemens-Martin Wendtner, Markus Muschen, Julia Jellusova, Jurgen Ruland, Maike Buchner
Summary: Inhibition of the phosphatases DUSP1 and DUSP6 reduces cell survival and induces cell death in chronic lymphocytic leukemia. Transient inhibition of DUSP1/6 shows promise as a treatment concept for drug-resistant CLL.
Review
Pharmacology & Pharmacy
Yixin Zheng, Jianan Zhao, Mi Zhou, Kai Wei, Ping Jiang, Lingxia Xu, Cen Chang, Yu Shan, Linshuai Xu, Yiming Shi, Steven J. Schrodi, Shicheng Guo, Dongyi He
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and joint damage. The altered expression of signaling lymphocytic activation molecule (SLAMF) receptors contributes to aberrant immune responses in RA. SLAMF receptors 1, 2, 4, 7, and 8 play various roles in promoting inflammation and immune cell activation in RA. Understanding the mechanisms of SLAMF regulation of immune cells in RA is crucial for developing targeted therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Emanuela M. Ghia, Laura Z. Rassenti, Michael Y. Choi, Miguel Quijada-Alamo, Elvin Chu, George F. Widhopf, Thomas J. Kipps
Summary: The Wnt5a-induced ROR1 signaling pathway can enhance resistance to venetoclax therapy in chronic lymphocytic leukemia (CLL) cells.
Article
Microbiology
Guoli Hou, Zhao Lv, Wenzhi Liu, Shuting Xiong, Qiushi Zhang, Chun Li, Xiaodong Wang, Liang Hu, Chunhua Ding, Rui Song, Hongquan Wang, Yong-An Zhang, Tiaoyi Xiao, Junhua Li
Summary: Viral seasonality in the aquaculture industry is a significant scientific issue, but the temperature-dependent pathogenesis of aquatic viral diseases remains poorly understood. This study demonstrates that grass carp reovirus (GCRV) exploits the IL6-STAT3-HSP90 signaling to promote viral entry in a temperature-dependent manner. The interaction between GCRV's major capsid protein VP7 and HSP90 facilitates viral entry. Understanding the molecular mechanism behind temperature-dependent viral pathogenesis can guide the development of targeted preventives and therapeutics for aquaculture viral diseases.
Article
Multidisciplinary Sciences
Shringar Rao, Cynthia Lungu, Raquel Crespo, Thijs H. Steijaert, Alicja Gorska, Robert-Jan Palstra, Henrieke A. B. Prins, Wilfred van Ijcken, Yvonne M. Mueller, Jeroen J. A. van Kampen, Annelies Verbon, Peter D. Katsikis, Charles A. B. Boucher, Casper Rokx, Rob A. Gruters, Tokameh Mahmoudi
Summary: This study demonstrates the selective induction of cell death in latent HIV-1-infected cells by DDX3 inhibitors, and provides evidence for the reduction of the inducible HIV-1 reservoir in CD4+ T cells from PLWHIV. The pharmacological targeting of DDX3 shows promise in reversing HIV-1 latency and eliminating the latent reservoir.
NATURE COMMUNICATIONS
(2021)
Article
Allergy
Huawei Mao, Wanling Yang, Sylvain Latour, Jing Yang, Sarah Winter, Jian Zheng, Ke Ni, Minmin Lv, Chenjing Liu, Hongmei Huang, Koon-Wing Chan, Pamela Pui-Wah Lee, Wenwei Tu, Alain Fischer, Yu-Lung Lau
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Letter
Biophysics
Zohreh Nademi, Robert F. Wynn, Mary Slatter, Stephen M. Hughes, Denise Bonney, Waseem Qasim, Sylvain Latour, Johannes Truck, Smita Patel, Mario Abinun, Terry Flood, Sophie Hambleton, Andrew J. Cant, Andrew R. Gennery, Peter D. Arkwright
BONE MARROW TRANSPLANTATION
(2019)
Article
Hematology
Shintaro Ono, Manabu Nakayama, Hirokazu Kanegane, Akihiro Hoshino, Saeko Shimodera, Hirofumi Shibata, Hisanori Fujino, Takahiro Fujino, Yuta Yunomae, Tsubasa Okano, Motoi Yamashita, Takahiro Yasumi, Kazushi Izawa, Masatoshi Takagi, Kohsuke Imai, Kejian Zhang, Rebecca Marsh, Capucine Picard, Sylvain Latour, Osamu Ohara, Tomohiro Morio
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2018)
Article
Medicine, Research & Experimental
David Boutboul, Hye Sun Kuehn, Zoe Van de Wyngaert, Julie E. Niemela, Isabelle Callebaut, Jennifer Stoddard, Christelle Lenoir, Vincent Barlogis, Catherine Farnarier, Frederic Vely, Nao Yoshida, Seiji Kojima, Hirokazu Kanegane, Akihiro Hoshino, Fabian Hauck, Ludovic Lhermitte, Vahid Asnafi, Philip Roehrs, Shaoying Chen, James W. Verbsky, Katherine R. Calvo, Ammar Husami, Kejian Zhang, Joseph Roberts, David Amrol, John Sleaseman, Amy P. Hsu, Steven M. Holland, Rebecca Marsh, Alain Fischer, Thomas A. Fleisher, Capucine Picard, Sylvain Latour, Sergio D. Rosenzweig
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Gastroenterology & Hepatology
Fabienne Charbit-Henrion, Marianna Parlato, Sylvain Hanein, Remi Duclaux-Loras, Jan Nowak, Bernadette Begue, Sabine Rakotobe, Julie Bruneau, Cecile Fourrage, Olivier Alibeu, Frederic Rieux-Laucat, Eva Levy, Marie-Claude Stolzenberg, Fabienne Mazerolles, Sylvain Latour, Christelle Lenoir, Alain Fischer, Capucine Picard, Marina Aloi, Jorge Amil Dias, Mongi Ben Hariz, Anne Bourrier, Christian Breuer, Anne Breton, Jiri Bronsky, Stephan Buderus, Mara Cananzi, Stephanie Coopman, Clara Cremilleux, Alain Dabadie, Clementine Dumant-Forest, Odul Egritas Gurkan, Alexandre Fabre, Aude Fischer, Marta German Diaz, Yago Gonzalez-Lama, Olivier Goulet, Graziella Guariso, Neslihan Gurcan, Matjaz Homan, Jean-Pierre Hugot, Eric Jeziorski, Evi Karanika, Alain Lachaux, Peter Lewindon, Rosa Lima, Fernando Magro, Janos Major, Georgia Malamut, Emmanuel Mas, Istvan Mattyus, Luisa M. Mearin, Jan Melek, Victor Manuel Navas-Lopez, Anders Paerregaard, Cecile Pelatan, Benedicte Pigneur, Isabel Pinto Pais, Julie Rebeuh, Claudio Romano, Nadia Siala, Caterina Strisciuglio, Michela Tempia-Caliera, Patrick Tounian, Dan Turner, Vaidotas Urbonas, Stephanie Willot, Frank M. Ruemmele, Nadine Cerf-Bensussan
JOURNAL OF CROHNS & COLITIS
(2018)
Review
Immunology
Sylvain Latour, Sarah Winter
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Allergy
Harry Sokol, Nizar Mahlaoui, Claire Aguilar, Perrine Bach, Olivier Join-Lambert, Aurelie Garraffo, Philippe Seksik, Francois Danion, Sarah Jegou, Marjolene Straube, Christelle Lenoir, Benedicte Neven, Despina Moshous, Stephane Blanche, Benedicte Pigneur, Olivier Goulet, Frank Ruemmele, Felipe Suarez, Laurent Beaugerie, Stephanie Pannier, Francoise Mazingue, Olivier Lortholary, Lionel Galicier, Capucine Picard, Genevieve de Saint Basile, Sylvain Latour, Alain Fischer
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Immunology
Claudine Joseph, Jihene Klibi, Ludivine Amable, Lorenzo Comba, Alessandro Cascioferro, Marc Delord, Veronique Parietti, Christelle Lenoir, Sylvain Latour, Bruno Lucas, Christophe Viret, Antoine Toubert, Kamel Benlagha
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Dominique Penther, Pierre-Julien Viailly, Sylvain Latour, Pascaline Etancelin, Elodie Bohers, Helene Vellemans, Vincent Camus, Anne Lise Menard, Sophie Coutant, Helene Lanic, Emilie Lemasle, Fanny Drieux, Liana Veresezan, Philippe Ruminy, Anna Raimbault, Jean Soulier, Thierry Frebourg, Herve Tilly, Fabrice Jardin
GENES CHROMOSOMES & CANCER
(2019)
Article
Allergy
Erinn S. Kellner, Christa Krupski, Hye Sun Kuehn, Sergio D. Rosenzweig, Nao Yoshida, Seiji Kojima, David Boutboul, Sylvain Latour, Vincent Barlogis, Claire Galambrun, Asbjorg Stray-Pedersen, Hans Christian Erichsen, Rebecca A. Marsh
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Letter
Allergy
Tariq Al Farsi, Stephen M. Hughes, Robert F. Wynn, Edmund Cheesman, Frederic Rieux-Laucat, Sylvain Latour, Capucine Picard, Sophie Hambleton, Peter D. Arkwright
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2019)
Article
Oncology
Laura Olivier-Gougenheim, Frederique Dijoud, Alexandra Traverse-Glehen, Sarah Benezech, Yves Bertrand, Sylvain Latour, Emilie Frobert, Carine Donnenech
HEMATOLOGICAL ONCOLOGY
(2019)
Review
Immunology
Sylvain Latour, Alain Fischer
IMMUNOLOGICAL REVIEWS
(2019)
Meeting Abstract
Oncology
Luis Alberto Perez Quintero, Michel L. Tremblay
Article
Medicine, Research & Experimental
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour
EMBO MOLECULAR MEDICINE
(2018)