Article
Allergy
Christine L. M. Joseph, Alexandra R. Sitarik, Haejin Kim, Gary Huffnagle, Kei Fujimura, Germaine Jia Min Yong, Albert M. Levin, Edward Zoratti, Susan Lynch, Dennis R. Ownby, Nicholas W. Lukacs, Brent Davidson, Charles Barone, Christine Cole Johnson
Summary: This study found that variations in infant gut bacterial composition were associated with the risk of IgE-FA at age 3-5, including lack of bacterial diversity and deficiencies in specific operational taxonomic units. The results support dysbiosis as a factor in the pathogenesis of IgE-FA.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dong-Geon Lee, Yu-Jin Lee, Song-Hee Park, Hye-Ree Park, Hoon Kang, Jung-Eun Kim
Summary: No effective therapeutic strategies have been developed against food allergies. Immunomodulation using human hematopoietic mesenchymal stem cells (hHMSCs) could prevent the development of food allergies. Treatment with hHMSCs or hHMSC culture medium significantly suppressed allergic responses, reduced diarrhea and allergy-related indicators. This treatment decreased Th2 cytokines levels and increased the expression of immune regulatory factors.
Review
Allergy
Tari Haahtela, Harri Alenius, Jenni Lehtimaki, Aki Sinkkonen, Nanna Fyhrquist, Heikki Hyoty, Lasse Ruokolainen, Mika J. Makela
Summary: The rise in allergic conditions is closely linked to the rapid growth of human activities, with changes in environment and lifestyle as the main causes. While advancements in treatment have helped control symptoms, prevention remains a challenge.
Review
Nutrition & Dietetics
Hanna Sikorska-Szaflik, Barbara Sozanska
Summary: Food allergy is a potentially life-threatening disease with genetic and environmental factors at play. While the role of diet modifications and nutrients in reducing food allergy has been extensively studied, less is known about other environmental factors that may influence its development.
Article
Allergy
Corinne Keet, Michael Pistiner, Mihaela Plesa, Daria Szelag, Wayne Shreffler, Robert Wood, Joan Dunlop, Roger Peng, Jennifer Dantzer, Alkis Togias
Summary: Moderate-severe eczema is a major risk factor for peanut allergy in infants, while family history of peanut allergy without eczema is not a significant risk factor. Screening is recommended for infants with significant eczema symptoms, and early introduction of peanut is associated with a lower risk of peanut allergy, even within the first year of life.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Ramin Beheshti, Shane Stone, Desirae Chandran, Steven D. Hicks
Summary: This study conducted multi-omic analyses on 164 infants to identify factors related to the development of food reactions (FR), finding associations with miR-203b-3p, Cyanobacteria, and Proteus virus PM135. Logistic regression models showed that these factors improved the accuracy of predicting future FRs in infants, with a 72% accuracy rate.
Review
Nutrition & Dietetics
Monika Niewiem, Urszula Grzybowska-Chlebowczyk
Summary: The role of intestinal permeability in food allergies is crucial, as it affects the immune system and the integrity of the epithelial barrier. However, the understanding of this process is still limited, and further research is needed to explore relevant indicators.
Review
Nutrition & Dietetics
Serena Coppola, Laura Carucci, Franca Oglio, Claudia Di Sarra, Gulsum Ozen, Roberto Berni Canani
Summary: Cow's milk allergy is a common pediatric food allergy that has increased in prevalence and severity due to environmental factors in genetically predisposed individuals. Nutritional factors, particularly diet, play a crucial role and can be targeted for prevention and treatment of CMA. This review provides scientific-based nutritional strategies for preventing and managing pediatric CMA and suggests comprehensive supplements to prevent nutrient deficiencies and influence the disease course.
Review
Nutrition & Dietetics
Dafni Moriki, Maria Pilar Francino, Despoina Koumpagioti, Barbara Boutopoulou, Jose Angel Rufian-Henares, Kostas N. Priftis, Konstantinos Douros
Summary: Cow's milk allergy is the most common food allergy in infancy and early childhood, with recent increases in allergy rates possibly linked to limited microbial exposure and changes in gut microbiome composition. The gut microbiome plays a crucial role in the host's lifelong health.
Review
Allergy
Marta Krawiec, Helen R. Fisher, George Du Toit, Henry T. Bahnson, Gideon Lack
Summary: Early introduction of allergenic food to induce oral tolerance has been shown effective in randomized controlled trials and incorporated into feeding guidelines, but further research is needed to address questions such as which foods to introduce early and the ideal timing for intervention.
Review
Food Science & Technology
Jialu Shi, Youfa Wang, Lei Cheng, Jin Wang, Vijaya Raghavan
Summary: Food allergy has become a global public health issue, especially in developed countries. Recent studies have shown that dysbiosis in the gut microbiota is strongly linked to the increasing prevalence of food allergy. Modulating the gut microbial composition is crucial in regulating the immunogenicity of food antigens. Therefore, probiotics, prebiotics, synbiotics, and postbiotics have attracted significant attention as innovative strategies for preventing and treating food allergy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Allergy
Susanne Halken, Antonella Muraro, Debra de Silva, Ekaterina Khaleva, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Henry T. Bahnson, Kirsten Beyer, Robert Boyle, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Kate Grimshaw, Arne Hoest, Carla Jones, Gideon Lack, Kari Nadeau, Liam O'Mahony, Hania Szajewska, Carina Venter, Valerie Verhasselt, Gary W. K. Wong, Graham Roberts
Summary: This guideline recommends approaches to prevent the development of immediate-onset/IgE-mediated food allergy in infants and young children, suggesting appropriate food introduction at specific times and avoiding regular cow's milk formula supplementation for breastfed infants.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Serena Coppola, Lorella Paparo, Lorenzo Chiariotti, Danilo Ercolini, Rita Nocerino, Anna Fiorenza de Giovanni di Santa Severina, Laura Carucci, Francesca De Filippis, Annalisa Agangi, Marcello Napolitano, Annalisa Passariello, Francesco Messina, Roberto Berni Canani
Summary: The study aims to investigate the impact of maternal adherence to the Mediterranean Diet on offspring allergic disorders, as well as other factors such as maternal weight gain, pregnancy complications, and gut microbiome features. The study protocol has been approved and will be conducted in accordance with ethical standards.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Johanna M. Smeekens, Brandi T. Johnson-Weaver, Andrew L. Hinton, M. Andrea Azcarate-Peril, Timothy P. Moran, Robert M. Immormino, Janelle R. Kesselring, Erin C. Steinbach, Kelly A. Orgel, Herman F. Staats, A. Wesley Burks, Peter J. Mucha, Martin T. Ferris, Michael D. Kulis
Summary: The study found that CC027/GeniUnc mice developed antigen-specific IgE responses to peanuts, walnuts, and eggs, but not milk, while C3H/HeJ mice were not sensitized to any antigen. Sensitized CC027/GeniUnc mice showed significant differences in gut microbiome composition and numbers of immune cells. These results suggest that there are multiple factors associated with enteric sensitization, including decreased fecal IgA levels, increased allergen absorption, and altered gut microbiome composition.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Elissa M. Abrams, Scott H. Sicherer
Summary: There is no defined standard of care for introducing tree nuts in children allergic to peanuts, and screening before introduction is controversial. Evidence suggests peanut-allergic children may be at higher risk for tree nut allergy, but this risk may be milder in infants. Familial hesitancy may influence the decision for pre-emptive screening before allergen introduction.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)