Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jingli Lu, Yan Liang, Haiyang Meng, Ailing Zhang, Junjie Zhao, Chengliang Zhang
Summary: The article discusses the metabolic and epigenetic features of Treg cells, as well as the impact of metabolites on epigenetic changes in Treg cells, which in turn affect the activation, differentiation, and function of Treg cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Samira Imran, Melanie R. Neeland, Stephen Peng, Amanda Vlahos, David Martino, Shyamali C. Dharmage, Mimi L. K. Tang, Susan Sawyer, Thanh D. Dang, Vicki McWilliam, Rachel L. Peters, Jennifer J. Koplin, Kirsten P. Perrett, Boris Novakovic, Richard Saffery
Summary: This study found that attenuated responses of naive CD4T cells in adolescents with food allergy are associated with specific epigenetic variations. These variations disrupt interferon responses and may contribute to the persistent food allergy phenotype. Further research is needed to validate these findings.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Cell Biology
Ahto Salumets, Liina Tserel, Anna P. Rumm, Lehte Turk, Kulli Kingo, Kai Saks, Astrid Oras, Raivo Uibo, Riin Tamm, Hedi Peterson, Kai Kisand, Part Peterson
Summary: Age-related changes in T-cell populations play an important role in immunosenescence. CD8(+) TEMRA cells and their subsets have characteristics of cellular senescence and increase in older individuals and age-related chronic inflammatory diseases. CD8(+) TEMRA proportions correlate with cytomegalovirus (CMV) antibody levels but not with chronological age. TRANCE/RANKL levels are associated with differentiated T-cell populations, including CD8(+) TEMRA and its CD28(-) subsets. Deep-amplicon bisulfite sequencing can be used to predict CD8(+) TEMRA cell proportions as a biomarker of immunosenescence.
Review
Nutrition & Dietetics
Hanna Danielewicz
Summary: Breastfeeding is a natural mode of nutrition that has beneficial effects on both the neonatal period and lifelong health. However, there is limited data on its protective effect against allergies. This review explores various factors that can modify the impact of breastfeeding, such as exposure to cow milk, supplement use, introduction of solid foods, microbiota changes, and the epigenetic function of breastfeeding.
Article
Allergy
Gui-Xiang Tian, Ke-Ping Peng, Ming-Hui Liu, Dao-Fa Tian, Hai-Qing Xie, Li-Wen Wang, Yu-Yang Guo, Shan Zhou, Li-Hua Mo, Ping-Chang Yang
Summary: This study found that a fraction of antigen-specific CD38(+) B cells were present in patients with perennial allergic rhinitis. These cells produce IL-6, which converts regulatory T cells into TH17 cells, thereby compromising the effects of allergen-specific immunotherapy. Inhibition of CD38(+) B cells enhances the effects of immunotherapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Elodie Renaude, Marie Kroemer, Christophe Borg, Paul Peixoto, Eric Hervouet, Romain Loyon, Olivier Adotevi
Summary: The review discusses the role of CD4(+) Th cells in anticancer immunity and emphasizes the importance of epigenetics. Research describes how epigenetic factors regulate the differentiation and recruitment of CD4(+) T cells. Furthermore, the potential of using epigenetic drugs to enhance anticancer immunotherapy is explored.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yinong Chao, Hua-Bing Li, Jing Zhou
Summary: RNA modification, particularly RNA methylation, plays a crucial role in regulating cell functions, including immune responses. Studying how RNA methylation regulates T cell function can provide a theoretical basis for potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Sloan A. Lewis, Aaron Sutherland, Ferran Soldevila, Luise Westernberg, Minori Aoki, April Frazier, Synaida Maiche, Mich Erlewyn-Lajeunesse, Hasan Arshad, Stephanie Leonard, Susan Laubach, Jennifer A. Dantzer, Robert A. Wood, Alessandro Sette, Gregory Seumois, Pandurangan Vijayanand, Bjoern Peters
Summary: This study examines the differences in allergen-specific T cells in cow milk allergic patients, aiming to identify potential diagnostic markers. The findings reveal significant changes in the transcriptional program and clonality of CM antigen-specific T cells in patients with cow milk allergy compared to those without. The increase in a specific type of T cells, FOXP3+ cells, is suggested as a potential diagnostic marker. Additionally, there is an observed increase in TH2 cells and markers associated with allergic diseases in cow milk allergic patients. These findings have implications for monitoring disease progression and the effectiveness of immunotherapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Hsi-en Ho, Yoojin Chun, Stephanie Jeong, Oranicha Jumreornvong, Scott H. Sicherer, Supinda Bunyavanich
Summary: Our study identified distinct microbial and metabolic profiles associated with mucosal immune disturbances in peanut allergy by analyzing oral microbiome, metabolism, and immune factors. The oral microbiome of individuals with peanut allergy showed reduced species in certain orders, lower levels of short-chain fatty acids, and increased IL-4 secretion.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Hannah Kube, Ronald Herrera, Gisela Dietrich-Guemperlein, Rudolf Schierl, Dennis Nowak, Katja Radon, Laura Wengenroth, Jessica Gerlich
Summary: The study found that the spreading of mouse allergens from laboratory animal workers' workplace to their home environment takes place, especially among workers involved in cleaning tasks. Dust sample analysis showed that cage cleaning tasks, infrequent changing of bed linen at home, and other factors were statistically associated with higher mouse allergen concentrations at home.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Review
Immunology
Eric Y. Helm, Liang Zhou
Summary: The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor that plays a role in immune cell environmental sensing. It regulates the development and function of innate lymphoid cells (ILCs) and their adaptive T cell counterparts. Both ILCs and T cells share some core transcription factors and effector molecules, but they have both shared and distinct mechanisms of regulation by Ahr. This review highlights the latest findings on Ahr's transcriptional regulation of ILCs and T cells, focusing on the shared and distinct mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Hong-Ren Yu, Te-Yao Hsu, Ching-Chang Tsai, Hsin-Chun Huang, Hsin-Hsin Cheng, Yun-Ju Lai, Yu-Ju Lin, Chih-Cheng Chen, Sung-Chou Li, Kuender Yang
Summary: l-Arginine has a significant impact on the DNA methylation profiles of CD4(+) T cells in neonates, leading to differences in gene activation and immune function compared to adults. Supplementation of l-arginine can modulate immune-related pathways in neonatal T cells and enhance IL-13 gene expression and cytokine production through hypomethylation of CpG dinucleotides. This study suggests that nutritional intervention with l-arginine could be a potential strategy to enhance immune function in neonates by targeting gene-specific DNA methylation.
Article
Biochemistry & Molecular Biology
Khalida Perveen, Alex Quach, Andrew McPhee, Susan L. Prescott, Simon C. Barry, Charles S. Hii, Antonio Ferrante
Summary: Regardless of the levels of PKC zeta expressed, immature cord blood T cells showed no differences in lymphocyte proliferation, cytokine production, maturation, or cell viability/apoptosis. However, upon maturation, cells with low PKC zeta levels produced lower levels of certain cytokines such as IFN-gamma, IL-2, and TNF, indicating a potential link to allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Allergy
Kiyoshi Hirahara, Ami Aoki, Toshinori Nakayama
Summary: Intractable chronic inflammatory diseases are caused by disruption of the immune system, with pathogenic Th cells playing a key role in the pathogenesis of these diseases. Recent research has revealed the generation of pathogenic Th cells with different characteristics during the memory T-cell stage in peripheral tissues, shedding light on the molecular mechanisms underlying these diseases. This review summarizes recent progress on the characteristics and actions of pathogenic Th cells, providing insights for future research directions in understanding and treating these diseases.
ALLERGOLOGY INTERNATIONAL
(2021)