Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Review
Oncology
Yan Zhang, Kaili Wang, Tao Yang, Yibo Cao, Wanling Liang, Xiangdong Yang, Tianbao Xiao
Summary: The meta-analysis in this study suggests that hepatic arterial infusion chemotherapy (HAIC) may be a potential therapeutic regimen that could improve the outcomes of patients with colorectal liver metastases.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Raja R. Narayan, Jashodeep Datta, Debra A. Goldman, Victoria G. Aveson, Henry S. Walch, Francisco Sanchez-Vega, Mithat Gonen, Vinod P. Balachandran, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham, Alice C. Wei, Nikolaus Schultz, Nancy E. Kemeny, Michael D'Angelica
Summary: Genomic alterations in KRAS, RAS/RAF, and RAS/RAF-TP53 are associated with earlier local and distant recurrence in resected colorectal liver metastasis patients receiving adjuvant hepatic artery infusion and/or systemic chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Xu, Yuqin Zhang, Charlie Zhilin Zheng, Cong Li, Tian'an Guo, Ye Xu
Summary: This study compared the therapeutic efficacy of thermal ablation (TA) and hepatic resection (HR) in patients with synchronous colorectal liver metastases (CRLM) without extrahepatic metastases. The results showed that TA and HR provide comparable five-year overall survival (OS) and disease-free survival (DFS) in these patients, but the TA group had a higher rate of local tumor progression.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Peter Schullian, Edward W. Johnston, Daniel Putzer, Gregor Laimer, Gregor Waroschitz, Eva Braunwarth, Arno Amann, Manuel Maglione, Reto Bale
Summary: The study demonstrates that multi-probe SRFA is an effective option for treating recurrent colorectal liver metastases with low morbidity rates and favorable clinical outcomes.
Article
Gastroenterology & Hepatology
Michael R. Driedger, Thomas S. Yamashita, Patrick Starlinger, Kellie L. Mathis, Rory L. Smoot, Sean P. Cleary, David M. Nagorney
Summary: The concurrent resection of primary cancer and synchronous colorectal cancer liver metastases (CRCLM) may lead to increased morbidity and mortality, especially in patients undergoing major liver/major colorectal resections. Postoperative complications may result in the inability to receive adjuvant chemotherapy, which could impact survival outcomes.
Review
Oncology
Michael J. Raphael, Paul J. Karanicolas
Summary: Regional therapies, such as hepatic arterial infusion pump chemotherapy and drug-eluting beads, are effective treatment options for patients with unresectable colorectal liver metastases. These therapies allow selective delivery of drugs to tumors while sparing normal liver tissue. However, there is a lack of randomized controlled trial evidence to guide the optimal integration of regional therapies into the management of colorectal liver metastases.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ralph Drewes, Maciej Pech, Maciej Powerski, Jazan Omari, Constanze Heinze, Robert Damm, Andreas Wienke, Alexey Surov
Summary: This meta-analysis aimed to evaluate the suitability of ADC as a predictor of response to systemic chemotherapy in patients with metastatic colorectal carcinoma. The results indicate that ADC can serve as a predictor of response to chemotherapy for CRC patients.
ACADEMIC RADIOLOGY
(2021)
Review
Oncology
Alexandra Nassar, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, David Fuks
Summary: This literature review aimed to assess the feasibility of laparoscopic liver resection for multiple colorectal liver metastases. The minimally invasive approach for liver cancer has become a new standard of oncological care, and laparoscopic liver resection is a significant indication for multiple colorectal liver metastases. The purpose of this paper was to highlight the novelty and updates in the field of multiple minimally invasive liver resections and discuss the feasibility and outcomes of laparoscopic concomitant multiple liver resections for colorectal liver metastases.
Article
Oncology
Florian E. Buisman, Wills F. Filipe, Nancy E. Kemeny, Raja R. Narayan, Rami M. Srouji, Vinod P. Balachandran, Thomas Boerner, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham, Alice C. Wei, Dirk J. Grunhagen, Cornelis Verhoef, Bas Groot Koerkamp, Michael I. D'Angelica
Summary: This study investigated the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases and found that adjuvant HAIP is associated with superior hepatic disease-free survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Lily V. Saadat, Thomas Boerner, Debra A. Goldman, Mithat Gonen, Timothy L. Frankel, Efsevia Vakiani, T. Peter Kingham, William R. Jarnagin, Alice C. Wei, Kevin C. Soares, David B. Solit, Michael I. D'Angelica
Summary: RAS mutations are prognostic for mCRC patients. KRAS exon 3/4 mutations are rare and may be associated with a more favorable prognosis, but the difference in oncologic outcomes based on the mutated exon appears to be smaller than previously reported.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
T. Susanna Meijer, Jan H. N. Dieters, Eleonora M. de Leede, Lioe-Fee de Geus-Oei, Jaap Vuijk, Christian H. Martini, Arian R. van Erkel, Jacob Lutjeboer, Rutger W. van der Meer, Fred G. J. Tijl, Ellen Kapiteijn, Alexander L. Vahrmeijer, Mark C. Burgmans
Summary: Percutaneous hepatic perfusion with melphalan (M-PHP) showed limited efficacy in patients with unresectable colorectal liver metastases who previously received systemic chemotherapy, but proved to be a safe procedure with manageable adverse events. Further research is warranted.
Article
Gastroenterology & Hepatology
Yoshikuni Kawaguchi, Scott Kopetz, Elena Panettieri, Hyunsoo Hwang, Xuemei Wang, Hop S. Tran Cao, Ching-Wei D. Tzeng, Yun Shin Chun, Thomas A. Aloia, Jean-Nicolas Vauthey
Summary: Survival in patients undergoing resection of colorectal liver metastases has improved over the past 20 years, associated with the introduction of irinotecan- and/or oxaliplatin-containing regimens, molecular targeted therapy, and multigene alteration testing. Liver resectability indications expanded over time, with a significantly better 5-year overall survival rate in 2006-2014 compared to 2001-2005. RAS alteration was associated with worse survival outcomes, while multigene alteration testing proved useful for prognostication and identification of potential therapeutic targets.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Review
Oncology
O. C. Freedman, G. G. Fletcher, S. Gandhi, M. Mates, S. F. Dent, M. E. Trudeau, A. Eisen
Letter
Oncology
Sukhbinder Dhesy-Thind, Glenn G. Fletcher, Mark Clemons, Catherine Van Poznak
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Sukhbinder Dhesy-Thind, Glenn G. Fletcher, Phillip S. Blanchette, Mark J. Clemons, Melissa S. Dillmon, Elizabeth S. Frank, Sonal Gandhi, Rasna Gupta, Mihaela Mates, Beverly Moy, Ted Vandenberg, Catherine H. Van Poznak
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Review
Oncology
S. Gandhi, G. G. Fletcher, A. Eisen, M. Mates, O. C. Freedman, S. F. Dent, M. E. Trudeau
Article
Oncology
M. Brackstone, G. G. Fletcher, I. S. Dayes, Y. Madarnas, S. K. SenGupta, S. Verma
Article
Oncology
A. Eisen, G. G. Fletcher, S. Gandhi, M. Mates, O. C. Freedman, S. F. Dent, M. E. Trudeau
Review
Oncology
M. Mates, G. G. Fletcher, O. C. Freedman, A. Eisen, S. Gandhi, M. E. Trudeau, S. F. Dent
Review
Surgery
Douglas Quan, Steven Gallinger, Cindy Nhan, Rebecca A. Auer, James J. Biagi, Glenn G. Fletcher, Calvin H. L. Law, Carol-Anne E. Moulton, Leyo Ruo, Alice C. Wei, Robin S. McLeod
Article
Oncology
T. M. Petrella, G. G. Fletcher, G. Knight, E. McWhirter, S. Rajagopal, X. Song, T. D. Baetz
Review
Oncology
Tara D. Baetz, Glenn G. Fletcher, Gregory Knight, Elaine McWhirter, Sudha Rajagopal, Xinni Song, Teresa M. Petrella
CANCER TREATMENT REVIEWS
(2020)
Article
Oncology
Andrea Eisen, Mark R. Somerfield, Melissa K. Accordino, Phillip S. Blanchette, Mark J. Clemons, Sukhbinder Dhesy-Thind, Melissa S. Dillmon, Stella D'Oronzo, Glenn G. Fletcher, Elizabeth S. Frank, Sigrun Hallmeyer, Issam Makhoul, Beverly Moy, Alia Thawer, Joy Y. Wu, Catherine H. Van Poznak
Summary: This article updates the recommendations of adjuvant bone-modifying agents in breast cancer treatment. Adjuvant bisphosphonate therapy should be discussed with all postmenopausal patients with primary breast cancer, regardless of hormone receptor status and human epidermal growth factor receptor 2 status. Adjuvant bisphosphonates are not substitutes for standard anticancer modalities and their benefits vary depending on the risk of recurrence. Factors influencing the decision to recommend adjuvant bisphosphonate use include patients' risk of recurrence, side effect risk, financial toxicity, drug availability, patient preferences, comorbidities, and life expectancy. Therapeutic options for preventing breast cancer recurrence include oral clodronate, oral ibandronate, and intravenous zoledronic acid. Early initiation of bisphosphonate therapy is recommended, and adjuvant denosumab is not recommended for preventing breast cancer recurrence.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Simron Singh, Glenn G. Fletcher, Xiaomei Yao, Jonathan Sussman
Summary: This systematic review compared virtual care with in-person care for cancer patients, finding that virtual care is equivalent to in-person care in the fields of psychological and genetic counseling. However, there is limited data regarding clinical outcomes and supportive care. Future research should focus on assessing the role of virtual care in these areas.
Correction
Surgery
Douglas Quan, Steven Gallinger, Cindy Nhan, Rebecca A. Auer, James J. Biagi, Glenn G. Fletcher, Calvin H. L. Law, Carolanne E. Moulton, Leyo Ruo, Alice C. Wei, Robin S. McLeod
Article
Environmental Sciences
LJS Tsuji, GG Fletcher, E Nieboer
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2002)