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Clinical Neurology
Thea Giacomini, Gianvittorio Luria, Vanessa D'Amario, Carolina Croci, Matteo Cataldi, Maria Piai, Giulia Nobile, Oliviero Bruni, Alessandro Consales, Maria Margherita Mancardi, Lino Nobili
Summary: The study shows that phasic REM sleep (PREM) has a greater suppressive effect on epileptic activity compared to tonic REM sleep (TREM). Even in the extreme condition of Electrical Status Epilepticus during Sleep (ESES), PREM still significantly reduces epileptic activity.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Soraia Ventura, Sean R. Mathieson, John M. O'Toole, Vicki Livingstone, Mary-Anne Ryan, Geraldine B. Boylan
Summary: The study aimed to characterize sleep features in 4-5 month old infants, providing normative values for sleep macrostructure and sleep spindles. Sex differences were observed in spindle spectral power and brain symmetry index, with males showing lower power and higher symmetry index compared to females. These findings contribute to a better understanding of infant sleep patterns and potential biomarkers for brain maturation.
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Chemistry, Physical
Jin-Hu Dou, Maxx Q. Arguilla, Yi Luo, Jian Li, Weizhe Zhang, Lei Sun, Jenna L. Mancuso, Luming Yang, Tianyang Chen, Lucas R. Parent, Grigorii Skorupskii, Nicole J. Libretto, Chenyue Sun, Min Chieh Yang, Phat Vinh Dip, Edward J. Brignole, Jeffrey T. Miller, Jing Kong, Christopher H. Hendon, Junliang Sun, Mircea Dinca
Summary: Researchers have successfully grown single crystals of 2D metal-organic frameworks up to 200 µm in size by balancing in-plane and out-of-plane interactions, revealing anisotropic transport and a clear correlation between conductivity and the nature of the metal cation in the sheets.
Article
Multidisciplinary Sciences
Stephen R. Morairty, Yu Sun, Lawrence Toll, Michael R. Bruchas, Thomas S. Kilduff
Summary: This study evaluated the effects of two NOPR agonists on sleep/wake in rats, mice, and Cynomolgus macaques. The results showed that these agonists increased non-Rapid Eye Movement sleep and electroencephalogram slow wave activity, while suppressing Rapid Eye Movement sleep in all three species. These findings suggest that the N/OFQ-NOPR system may have a previously unrecognized role in sleep/wake control and could be a potential therapeutic target for insomnia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Qilong Xin, Robin K. Yuan, Kirsi-Marja Zitting, Wei Wang, Shaun M. Purcell, Nina Vujovic, Joseph M. Ronda, Stuart F. Quan, Jonathan S. Williams, Orfeu M. Buxton, Jeanne F. Duffy, Charles A. Czeisler
Summary: Chronic sleep restriction may have a persistent impact on sleep quality and depth, but this improvement is associated with deterioration in neurobehavioral performance. This has implications for long-term use of sleep restriction in the treatment of insomnia.
Article
Multidisciplinary Sciences
Madan Parajuli, Amy W. W. Amara, Mohamed Shaban
Summary: In this study, deep-learning based approaches were proposed to detect mild cognitive impairment in Parkinson's disease by analyzing sleep Electroencephalography signals. The proposed models achieved accurate prediction and identification of mild cognitive impairment, providing a promising computer-aided diagnostic tool for monitoring the progression of Parkinson's disease.
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Neurosciences
Lais F. Berro, John S. Overton, James K. Rowlett
Summary: The use of amphetamine-type stimulants, such as methamphetamine, is associated with various negative health outcomes, including sleep disturbances. This study investigated the effects of acute morning administration of methamphetamine on sleep parameters in adult male rhesus monkeys. The results showed that methamphetamine altered sleep architecture, including increased sleep latency and wake time after sleep onset, decreased total sleep time, and changes in sleep stage distribution. Sleep rebound effects were observed on the subsequent night.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Zonglin Li, Mingxin Xie, Guozheng Nie, Junhui Wang, Lujun Huang
Summary: In this study, we developed an optical biosensor based on an all-dielectric metasurface with broken symmetry. The biosensor exhibited excellent performance, thanks to the high-Q quasi-bound states in the continuum (qBICs) and the efficient field confinement. It has potential applications in extreme biochemical sensing, such as COVID-19 detection at ultralow concentrations.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Computer Science, Artificial Intelligence
Georg Brandmayr, Manfred Hartmann, Franz Furbass, Gerald Matz, Matthias Samwald, Tilmann Kluge, Georg Dorffner
Summary: This study introduces an EEG representation model called ENGELBERT, which addresses the issue of lack of REM scoring quality in single EEG channel models by jointly attending to multiple EEG epochs from both past and future. Compared to established LSTM models, ENGELBERT is smaller and easier to train, achieving higher F1 scores in sleep scoring experiments.
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Agriculture, Dairy & Animal Science
Endre Putyora, Sarah Brocklehurst, Frank Tuyttens, Victoria Sandilands
Summary: The positive welfare of commercial animals has many benefits, so it is important to accurately assess welfare. This study aimed to establish a baseline for sleep behavior in laying hens and observed the effects of short-term disturbances. The results showed that laying hens were resilient to short-term sleep disruption and it did not impact their long-term welfare.
Article
Clinical Neurology
Katharina Schiller, Nicolas von Ellenrieder, Tamir Avigdor, Charbel El Kosseifi, Chifaou Abdallah, Erica Minato, Jean Gotman, Birgit Frauscher
Summary: The study found that patients with focal epilepsy, especially extratemporal lobe epilepsy, show a global reduction in STW activity during REM sleep. This suggests that epilepsy can affect cortically generated sleep oscillations even in REM sleep when epileptic activity is low.
Article
Clinical Neurology
Binney Sharma, Avishek Roy, Trina Sengupta, Lal Chandra Vishwakarma, Anuraag Singh, Ritesh Netam, Tapas Chandra Nag, Nasreen Akhtar, Hruda Nanda Mallick
Summary: Sleep has an impact on both brain function and neuromuscular junction morphology and neurochemistry.
Article
Psychiatry
Katia Gagnon, Christianne Bolduc, Laurianne Bastien, Roger Godbout
Summary: The study revealed an atypical scalp distribution of EEG activity during REM sleep in young adults with autism, which correlated with certain ASD symptoms. This suggests a potential common substrate between some ASD symptoms and abnormal thalamo-cortical loop organization during REM sleep in autism.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Yi-Ge Huang, Sarah J. Flaherty, Carina A. Pothecary, Russell G. Foster, Stuart N. Peirson, Vladyslav V. Vyazovskiy
Summary: The study found that during fasting-induced torpor, mice showed progressively deeper and longer bouts of hypothermia, affecting EEG and EMG. Despite a decrease in REM sleep during deep hypothermia, intense bursts of muscle activity were observed. These findings suggest important similarities between EEG signatures of fasting-induced torpor in mice and hibernation in other species.
Editorial Material
Biochemistry & Molecular Biology
Paul-Antoine Libourel, John A. Lesku
Summary: A recent study reveals that bearded dragons possess a unique mechanism to synchronize sleep state changes between brain hemispheres. The dominant hemisphere during REM sleep-like state exerts its influence on the other hemisphere.
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Immunology
G. Hurtado-Alvarado, E. Becerril-Villanueva, A. Contis-Montes de Oca, E. Dominguez-Salazar, N. Salinas-Jazmin, S. M. Perez-Tapia, L. Pavon, J. Velazquez-Moctezuma, B. Gomez-Gonzalez
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Immunology
Francisco Nachon-Garcia, Gabriela Hurtado-Alvarado, Mario E. Acosta-Hernandez, Carolina Pena-Escudero, Sergio Priego-Fernandez, Samantha Alvarez-Herrera, Enrique Becerril-Villanueva, Gilberto Perez-Sanchez, Lenin Pavon, Fabio Garcia-Garcia
JOURNAL OF NEUROIMMUNOLOGY
(2018)
Article
Behavioral Sciences
Marcel Perez-Morales, Gabriela Hurtado-Alvarado, Itzel Morales-Hernandez, Beatriz Gomez-Gonzalez, Emilio Dominguez-Salazar, Javier Velazquez-Moctezuma
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2018)
Article
Clinical Neurology
Emilio Dominguez-Salazar, Gabriela Hurtado-Alvarado, Fernanda Medina-Flores, Javik Dorantes, Oscar Gonzalez-Flores, Arturo Contis-Montes de Oca, Javier Velazquez-Moctezuma, Beatriz Gomez-Gonzalez
JOURNAL OF SLEEP RESEARCH
(2020)
Article
Immunology
Fernanda Medina-Flores, Gabriela Hurtado-Alvarado, Arturo Contis-Montes de Oca, Stefanie Paola Lopez-Cervantes, Mina Konigsberg, Maria A. Deli, Beatriz Gomez-Gonzalez
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Review
Endocrinology & Metabolism
Samantha Alvarez-Herrera, Raul Escamilla, Oscar Medina-Contreras, Ricardo Saracco, Yvonne Flores, Gabriela Hurtado-Alvarado, Jose Luis Maldonado-Garcia, Enrique Becerril-Villanueva, Gilberto Perez-Sanchez, Lenin Pavon
FRONTIERS IN ENDOCRINOLOGY
(2020)
Review
Endocrinology & Metabolism
Ruud M. Buijs, Gabriela Hurtado-Alvarado, Eva Soto-Tinoco
Summary: Vasopressin is an important hormone with antidiuretic and vasoconstrictor functions produced in the supraoptic and paraventricular nucleus. It acts as a neurotransmitter and is influenced by various stimuli, with its production and release regulated by the biological clock. The interplay between SCN circadian output and peripheral feedback is essential for regulating all circadian rhythms in physiology and behavior.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Review
Behavioral Sciences
Jesus Enrique Garcia-Aviles, Rebeca Mendez-Hernandez, Mara A. Guzman-Ruiz, Miguel Cruz, Natali N. Guerrero-Vargas, Javier Velazquez-Moctezuma, Gabriela Hurtado-Alvarado
Summary: Sleep plays a crucial role in learning, memory consolidation, and metabolic function. Sleep restriction may increase the accumulation of Aβ and the risk of developing AD. Chronic sleep restriction can lead to metabolic and cognitive impairments, potentially contributing to the development of AD.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2021)
Review
Cell Biology
Fernanda Medina-Flores, Gabriela Hurtado-Alvarado, Maria A. Deli, Beatriz Gomez-Gonzalez
Summary: Microvessels in the CNS have a high population of pericytes, which are crucial for maintaining homeostasis and regulating inflammation in the central nervous system.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Betty Rodriguez-Cortes, Gabriela Hurtado-Alvarado, Ricardo Martinez-Gomez, Luis A. Leon-Mercado, Masha Prager-Khoutorsky, Ruud M. Buijs
Summary: This study reveals that the biological clock regulates the day-night variations in blood glucose levels through the release of vasopressin and the promotion of glucose entrance into the arcuate nucleus via GLUT1 transporter.
Article
Psychology, Biological
C. Javik Dorantes-Barrios, Emilio Dominguez-Salazar, Oscar Gonzalez-Flores, Edith Cortes-Barberena, Gabriela Hurtado-Alvarado
Summary: The large litter size in rat models may affect memory processes and anxiety-like behavior, while its impact on sexual behavior and the reproductive system remains uncertain. Environmental enrichment can influence behavior and correct some alterations caused by postnatal undernutrition.
PHYSIOLOGY & BEHAVIOR
(2021)
Review
Neurosciences
Mara A. Guzman-Ruiz, Natali N. Guerrero-Vargas, Alejandra Lagunes-Cruz, Shellye Gonzalez-Gonzalez, Jesus Enrique Garcia-Aviles, Gabriela Hurtado-Alvarado, Rebeca Mendez-Hernandez, Anahi Chavarria-Krauser, Jean-Pascal Morin, Virginia Arriaga-Avila, Ruud M. Buijs, Rosalinda Guevara-Guzman
Summary: Microglia, the resident macrophages in the CNS, exhibit circadian gene and protein expression and respond differently to immune challenges depending on the time of day. Their functions, such as synaptic prune and regulation of biological rhythms like general activity, body temperature, and food intake, are influenced by circadian control. This reveals the importance of considering circadian time in understanding the role of microglia in CNS physiology.