Review
Geriatrics & Gerontology
Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: The article focuses on the pathogenesis and neuroimaging features of white matter lesions (WMLs), revealing a series of pathophysiological findings and discussions about WMLs and providing robust references for clinicians to further understand and customize treatment strategies for different WML patterns caused by vascular etiologies.
Article
Clinical Neurology
Hsin-Hsi Tsai, Ya-Fang Chen, Ruoh-Fang Yen, Yen-Ling Lo, Kai-Chien Yang, Jiann-Shing Jeng, Li-Kai Tsai, Che-Feng Chang
Summary: The study indicates that plasma soluble TREM2 is associated with white matter hyperintensity independent of amyloid and tau pathology, suggesting its potential utility as a predictive marker for small vessel disease-related white matter injury.
Article
Clinical Neurology
Keun-Hwa Jung, Kimberly A. Stephens, Kathryn M. Yochim, Joost M. Riphagen, Chan Mi Kim, Randy L. Buckner, David H. Salat
Summary: The study successfully differentiated different classes of cerebral white matter signal abnormalities (WMSA) using automated procedures and found that different classes of WMSA are associated with different clinical risk factors.
Article
Neurosciences
Rachel A. Crockett, Chun Liang Hsu, Elizabeth Dao, Roger Tam, Janice J. Eng, Todd C. Handy, Teresa Liu-Ambrose
Summary: White matter hyperintensities (WMH) are associated with cognitive impairment in cerebral small vessel disease, potentially due to disruption of large-scale functional networks. Lesion network mapping can help identify how disruptions to specific functional networks, such as the visual, ventral attention, and frontoparietal networks, are associated with poorer cognition in older adults with cerebral small vessel disease. In particular, disruption to the sensorimotor and ventral attention networks may contribute to deficits in global cognition.
Review
Clinical Neurology
Mykyta Smirnov, Christophe Destrieux, Igor Lima Maldonado
Summary: This review provides a structured presentation of the existing knowledge of the vascularization of the human cerebral white matter from seminal historical studies to the current literature, emphasizing the transition in conceptions of white matter vascularization and the need for further research on deep white matter vascularization, especially regarding the arterial supply of white matter fibre tracts.
Review
Pathology
Katharina Eikermann-Haerter, Susie Y. Huang
Summary: Migraine is a well-known risk factor for subclinical focal deep white matter lesions, with ischemic and inflammatory mechanisms proposed as underlying causes, negatively impacting both physical and cognitive functions.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Yujuan Yuan, Nanfang Li, Yan Liu, Qing Zhu, Mulalibieke Heizhati, Weiwei Zhang, Xiaoguang Yao, Deilian Zhang, Qin Luo, Menghui Wang, Guijuan Chang, Mei Cao, Keming Zhou, Lei Wang, Junli Hu, Nuerguli Maimaiti
Summary: This study analyzed the relationship between aldosterone and white matter lesions in a population with hypertension. The results showed that individuals with higher plasma aldosterone concentration (PAC > 17.26 ng/dl) had an increased risk of white matter lesions, and PAC was positively associated with white matter lesion load independently of systolic or diastolic blood pressure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Ami Tsuchida, Philippe Boutinaud, Violaine Verrecchia, Christophe Tzourio, Stephanie Debette, Marc Joliot
Summary: White matter hyperintensities (WMHs) are markers of cerebral small vessel disease, associated with increased risk of stroke, dementia, and mortality. This study presents an automatic WMH segmentation tool based on deep learning, which can efficiently detect WMH with high accuracy.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Simone M. Uniken Venema, Alida A. Postma, Ido R. van den Wijngaard, Jan Albert Vos, Hester F. Lingsma, Reinoud P. H. Bokkers, Jeannette Hofmeijer, Diederik W. J. Dippel, Charles B. Majoie, H. Bart van Der Worp
Summary: In patients treated with endovascular treatment for acute ischemic stroke, an increasing burden of cerebral white matter lesions at baseline is associated with poorer clinical outcomes, but not with the probability of successful reperfusion or symptomatic intracranial hemorrhage.
Article
Biochemistry & Molecular Biology
Reut Guy, Rotem Volkman, Ella Wilczynski, Chana Yagil, Yoram Yagil, Michael Findler, Eitan Auriel, Uri Nevo, Daniel Offen
Summary: In this study, a novel rat model for cerebral small vessel disease (CSVD) was described. The model, utilizing hypertension-prone rats, displayed multiple cerebrovascular pathologies associated with CSVD and may provide a platform for further understanding the mechanisms of the disease and testing novel therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hui-hong Tang, Yan-juan Wang, Zan Wang, Gao-liang Yan, Yong Qiao, Xudong Li, Dong Wang, Cheng-chun Tang
Summary: This study aims to build a model to identify patients who suffered from moderate-to-severe white matter lesions (WMLs) by using recognized WMLs risk factors including age, history of diabetes, and platelet-to-white blood cell ratio (PWR). A nomogram was developed to predict the risk of WMLs, and the study provides a potential tool to identify cerebrovascular disease in patients with hypertension.
Article
Clinical Neurology
Eric Fang, Mario Joao Fartaria, Chu Ning Ann, Benedicte Marechal, Tobias Kober, Jie Xin Lim, Leon Qi Rong Ooi, Celeste Chen, Soo Lee Lim, Eng King Tan, Ling Ling Chan
Summary: This study evaluates WML volumes and distribution in PD patients using a fully automated multi-modal segmentation algorithm. The results show that WML volume strongly correlates with motor and cognitive dysfunctions in PD patients, with different impacts in different brain regions. Automated multi-modal segmentation algorithms have the potential to be imaging biomarkers for predicting domain-specific disease severity in PD.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Guy Heiman, Marisa Mendes, Francesco Nicita, Lama Darbelli, Omar Sherbini, Travis Moore, Alexa Derksen, Amy Pizzino, Rosalba Carrozzo, Alessandra Torraco, Michela Catteruccia, Chiara Aiello, Paola Goffrini, Sonia Figuccia, Desiree E. C. Smith, Kinga Hadzsiev, Andreas Hahn, Saskia Biskup, Ines Broesse, Urania Kotzaeridou, Darja Gauck, Theresa A. Grebe, Frances Elmslie, Karen Stals, Rajat Gupta, Enrico Bertini, Isabelle Thiffault, Ryan J. Taft, Raphael Schiffmann, Ulrich Brandl, Tobias B. Haack, Gajja S. Salomons, Cas Simons, Genevieve Bernard, Marjo S. van der Knaap, Adeline Vanderver, Ralf A. Husain
Summary: This study identified two distinct phenotypes in individuals with AARS1-related disease, early infantile-onset and later-onset, both of which showed significantly reduced AlaRS activity. Longitudinal imaging and clinical follow-up are recommended for understanding disease progression and outcome variability.
GENETICS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi
Summary: Palmitoylethanolamide (PEA) is a naturally occurring amide compound with analgesic, neuroprotective, immune-modulating, and anti-inflammatory effects. Recent studies have shown that PEA promotes oligodendrocyte differentiation, which is crucial for myelin formation. PEA has therapeutic potential in restoring white matter defects.
Article
Clinical Neurology
Anne Adlung, Melina Samartzi, Lothar R. Schad, Eva Neumaier-Probst, Marc Fatar, Sherif A. Mohamed
Summary: The study evaluated the correlation between WM TSC and the extent of small vessel disease in patients with acute ischemic stroke, finding that TSC in WM was significantly higher in patients with Fazekas grade III compared to other grades, and showed a positive correlation with Fazekas grades. The research also highlighted that differences in absolute TSC in evaluating acute ischemic stroke may lead to inaccuracies in rTSC quantification.
CEREBROVASCULAR DISEASES
(2021)
