Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Neurosciences
Daniela Madeira, Catia R. Lopes, Ana P. Simoes, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study found that silencing the A(2A)R gene in astrocytes leads to deficits in hippocampal synaptic plasticity and memory. Astrocytic A(2A)R control astrocytic morphology and influence hippocampal synaptic plasticity and memory in adult mice.
Article
Biochemistry & Molecular Biology
Irene Sanchez-Rodriguez, Sara Temprano-Carazo, Danko Jeremic, Jose Maria Delgado-Garcia, Agnes Gruart, Juan D. Navarro-Lopez, Lydia Jimenez-Diaz
Summary: Synaptic plasticity is a cellular process involved in learning and memory, which adapts the synaptic strength and efficacy of neural transmission. The induction of synaptic plasticity is regulated by the balance between excitatory and inhibitory synaptic transmission. Limited studies have been done on long-lasting synaptic modifications during memory formation in freely moving animals. This study recorded field postsynaptic potentials in freely moving mice during an object recognition task and found that the synaptic plasticity of specific synapses in the dorsal hippocampus was enhanced when exploring novel objects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana Patricia Simoes, Francisco Q. Goncalves, Daniel Rial, Samira G. Ferreira, Joao Pedro Lopes, Paula M. Canas, Rodrigo A. Cunha
Summary: CD73 plays a key role in the regulation of fear memory and synaptic plasticity in the amygdala, suggesting it as a potential therapeutic target for interfering with abnormal fear-like emotional processing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Ana Belen Sanz-Martos, Jesus Fernandez-Felipe, Beatriz Merino, Victoria Cano, Mariano Ruiz-Gayo, Nuria Del Olmo
Summary: Our study demonstrates that butyric acid has a positive influence on long-term potentiation (LTP) and hippocampus-dependent spatial memory, suggesting its potential beneficial effects on memory.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Lorenzo More, Lucia Privitera, Daniel D. Cooper, Marianthi Tsogka, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: Positive experiences, such as social interaction, cognitive training, and physical exercise, can improve cognitive abilities and synaptic plasticity associated with ageing. However, the mechanisms through which the environment influences neuronal response and adaptation to these positive sensory experiences remain unclear.
Article
Biochemistry & Molecular Biology
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Summary: Acute hippocampal slice preparations have been commonly used in studying the anti-amnesic properties of drug candidates on long-term potentiation (LTP). Genetic background is crucial in experimental design, considering the availability of various transgenic mouse models. In this study, LTP was compared between inbred and outbred mice, showing reduced LTP magnitude in outbred mice due to lower responsiveness to theta-frequency during conditioning stimuli. Overall, this study highlights the importance of considering animal models in electrophysiological experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Neurosciences
Gholam Hossein Meftahi, Mahnaz Bayat, Amir Hossein Zarifkar, Somaye Akbari, Afshin Borhani Haghighi, Maryam Naseh, Amirhossein Yousefi Nejad, Masoud Haghani
Summary: The study aimed to investigate the effects of edaravone administration on cellular and electrophysiological properties in a rat model of vascular dementia induced by bilateral carotid artery occlusion. The results showed that vascular dementia led to increased MDA levels, neuronal loss, reduced hippocampal volume, and impaired synaptic plasticity and memory function. However, treatment with edaravone decreased MDA levels, prevented neuronal loss and hippocampal volume reduction, improved synaptic plasticity and memory function.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Marlene F. Pereira, Ines M. Amaral, Catia Lopes, Catarina Leitao, Daniela Madeira, Joao P. Lopes, Francisco Q. Goncalves, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study shows that L-alpha-aminoadipate (L-AA) affects astrocytes differently and impairs synaptic plasticity and memory. Injection of L-AA negatively impacts hippocampal long-term potentiation (LTP) and hippocampal-dependent memory in mice. D-serine administration can partially rescue the reduction in hippocampal LTP induced by L-AA exposure.
Article
Neurosciences
L. Fester, Gabriele M. Rune
Summary: Hippocampal neurons have the ability to synthesize sex steroids from cholesterol, with estradiol and testosterone playing important roles in maintaining synaptic transmission and connectivity. The synthesis of these steroids is regulated by internal and external factors, and there are sex-specific differences in how estradiol and dihydrotestosterone affect synaptic functions. The link between GnRH-induced estradiol synthesis and cyclical changes in spine density in the female hippocampus suggests a complex interaction between the hypothalamus and hippocampus in regulating neuronal responses to sex neurosteroids.
NEUROSCIENCE LETTERS
(2021)
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Cell Biology
Ann Katrin Greifenberg, Dana Hoenig, Kveta Pilarova, Robert Duester, Koen Bartholomeeusen, Christian A. Boesken, Kanchan Anand, Dalibor Blazek, Matthias Geyer
Article
Biochemistry & Molecular Biology
Vera Hauptstock, Sapuna Kuriakose, Doris Schmidt, Robert Duester, Stefan C. Mueller, Alexander von Ruecker, Joerg Ellinger
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Biochemistry & Molecular Biology
Apoorva Baluapuri, Julia Hofstetter, Nevenka Dudvarski Stankovic, Theresa Endres, Pranjali Bhandare, Seychelle Monique Vos, Bikash Adhikari, Jessica Denise Schwarz, Ashwin Narain, Markus Vogt, Shuang-Yan Wang, Robert Duester, Lisa Anna Jung, Jens Thorsten Vanselow, Armin Wiegering, Matthias Geyer, Hans Michael Maric, Peter Gallant, Susanne Walz, Andreas Schlosser, Patrick Cramer, Martin Eilers, Elmar Wolf
Article
Biochemistry & Molecular Biology
Andrii Bugai, Alexandre J. C. Quaresma, Caroline C. Friedel, Tina Lenasi, Robert Duester, Christopher R. Sibley, Koh Fujinaga, Petra Kukanja, Thomas Hennig, Melanie Blasius, Matthias Geyer, Jernej Ule, Lars Doelken, Matjaz Barboric
Article
Biochemistry & Molecular Biology
Robert Duester, Ines H. Kaltheuner, Maximilian Schmitz, Matthias Geyer
Summary: The widespread use of 1,6-hexanediol in phase separation studies may have significant effects on the activities of various enzymes, particularly kinases and phosphatases. This highlights the need for a reevaluation of the use of 1,6-hexanediol in research studies.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ines H. Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Duester, Jinhua Wang, Nathanael S. Gray, Matthias Geyer
Summary: Abemaciclib, a CDK inhibitor for breast cancer treatment, also targets HIPKs and DYRK1A. HIPKs play a role in signal pathway regulation, and DYRK1A is inhibited by Abemaciclib in vitro to a similar extent as Cdk4/Cdk6.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Robert Duester, Yanlong Ji, Kuan-Ting Pan, Henning Urlaub, Matthias Geyer
Summary: In this study, the substrate specificity and function of Cdk10 were thoroughly analyzed, revealing its important role in cell cycle regulation and transcriptional regulation. Cdk10 can act as a tumor suppressor and potentially interact with other CDKs.
Article
Oncology
Kai Funke, Robert Duster, Prince De-Graft Wilson, Lena Arevalo, Matthias Geyer, Hubert Schorle
Summary: Transcriptional cyclin-dependent kinase inhibitors have shown high cytotoxicity on certain testicular germ cell tumor cell lines, suggesting a promising alternative treatment option for type II testicular germ cell tumors.
Article
Biochemistry & Molecular Biology
Calla M. Olson, Yanke Liang, Alan Leggett, Woojun D. Park, Lianbo Li, Caitlin E. Mills, Selma Z. Elsarrag, Scott B. Ficarro, Tinghu Zhang, Robert Duester, Matthias Geyer, Taebo Sim, Jarrod A. Marto, Peter K. Sorger, Ken D. Westover, Charles Y. Lin, Nicholas Kwiatkowski, Nathanael S. Gray
CELL CHEMICAL BIOLOGY
(2019)