Review
Biochemistry & Molecular Biology
Marzia Friuli, Barbara Eramo, Marta Valenza, Caterina Scuderi, Gustavo Provensi, Adele Romano
Summary: This review aims to explore the role of oxytocin in modulating inflammation in different chronic diseases by selecting diseases based on emerging literature, demonstrating the beneficial effects of oxytocin in these pathological processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Xinxin Zhang, Yuxi Sun, Ning Wang, Yanli Zhang, Yunlong Xia, Ying Liu
Summary: Cardio-oncology is a nascent specialty that aims to address the cardiovascular complications of cancer therapies. Some anti-tumor drugs have cardioprotective effects in addition to their cancer treatment properties. B cells participate in and promote the progression of cardiovascular diseases, suggesting novel immunomodulatory therapeutic strategies targeting B cells and their products.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yi-Xuan Li, Hong-Bo Wang, Jing Li, Jian-Bo Jin, Jing-Bo Hu, Chun-Lin Yang
Summary: Pulmonary vascular endothelial cells play a crucial role in respiratory diseases, and targeting them through drug delivery systems can effectively treat these diseases. The unique structure and blood perfusion rate of pulmonary vessels promote drug distribution in lung tissues.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Si Han Li, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson
Summary: Glutamate, the primary excitatory neurotransmitter in the brain, plays crucial roles in neuronal function. mGluR2 and mGluR3, members of the Group II mGluR family, have been implicated in the pathophysiology of various neurodegenerative and neuropsychiatric diseases, making them potential drug targets for treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Shilpi Singh, Debashis Barik, Ananta Prasad Arukha, Sujata Prasad, Iteeshree Mohapatra, Amar Singh, Gatikrushna Singh
Summary: This article introduces strategies to modify immune cells within the tumor microenvironment using small molecules, potentially revolutionizing therapeutic interventions and enhancing the anti-tumor response.
Review
Cell Biology
Yuhong Liu, Zhihua Tu, Xi Zhang, Keqian Du, Zhengquan Xie, Zhiming Lin
Summary: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with a complex pathogenesis. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of SLE that involves the nervous system and produces neurological or psychiatric symptoms. The mechanisms of NPSLE involve genetic factors, blood-brain barrier dysfunction, vascular lesions, multiple autoimmune antibodies, cytokines, and neuronal cell death. Due to the complexity and clinical overlap with other neurological or psychiatric disorders, the accurate diagnosis and treatment of NPSLE is challenging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Adil El Midaoui, Imen Ghzaiel, Dominique Vervandier-Fasseur, Mohamed Ksila, Amira Zarrouk, Thomas Nury, Farid Khallouki, Aboubaker El Hessni, Salama Ouazzani Ibrahimi, Norbert Latruffe, Rejean Couture, Omar Kharoubi, Fatiha Brahmi, Sonia Hammami, Olfa Masmoudi-Kouki, Mohamed Hammami, Taoufik Ghrairi, Anne Vejux, Gerard Lizard
Summary: Saffron, a medicinal plant rich in carotenoids and terpenes, has powerful antioxidant and anti-inflammatory properties. Its beneficial effects on neuropsychiatric and age-related diseases make it significant in promoting human health.
Review
Cardiac & Cardiovascular Systems
Emily F. Warner, Yang Li, Xuan Li
Summary: This review examines the functions of microtubules in the cardiovascular system and their role in cardiac disorders. Currently, there are limited treatments targeting microtubule-relevant mechanisms, but microtubule-targeting drugs show promise as future therapeutic options for heart diseases.
CIRCULATION RESEARCH
(2022)
Article
Chemistry, Medicinal
Haobai Liu, Quan Wang, Yue Huang, Jinhui Deng, Xi Xie, Jiaqi Zhu, Yijun Yuan, Yue-Ming He, Yi-You Huang, Hai-Bin Luo, Xixin He
Summary: In this study, a natural derivative of mangostanin called 22d was discovered as a potential novel anti-inflammatory bowel disease (IBD) agent. This compound showed potent inhibition of PDE4 and did not cause any side effects in animal experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Jon Macicior, Beatriz Marcos-Ramiro, Silvia Ortega-Gutierrez
Summary: Progeria is a rare genetic disorder caused by a point mutation in the lamin A gene, resulting in abnormal accumulation of progerin. Patients typically die prematurely at the average age of 14.5 due to significant alterations in the cardiovascular system, bones, skin, and overall growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Ana Merino-Vico, Giulia Frazzei, Jan Piet van Hamburg, Sander W. Tas
Summary: Autoimmune diseases are characterized by inflammation and tissue damage caused by the immune system recognizing self-antigens. B cells play a critical role in autoimmunity and have been identified as therapeutic targets. This review article provides an overview of novel strategies to target B cells in autoimmune diseases, with a focus on rheumatic diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Chirag Jain, Ansarullah, Sara Bilekova, Heiko Lickert
Summary: This review discusses emerging concepts in diabetes therapy that focus on altering the biology and function of beta cells, such as insulin signaling, proliferation, differentiation, apoptosis, and the selective killing of senescent beta cells. The review highlights that targeting beta cells pharmacologically can protect and regenerate beta cells, leading to improved treatment outcomes for patients with diabetes.
Review
Immunology
Xinting Wang, Hua Zhou, Qian Liu, Peipei Cheng, Tingyao Zhao, Tianshu Yang, Yue Zhao, Wanjing Sha, Yanyan Zhao, Huiyan Qu
Summary: Cardiovascular diseases (CVDs) are a major cause of global death and disability, with inflammatory progression and immune responses playing a crucial role. Regulatory T cells (Tregs), as a subset of CD4(+)T cells, have immunosuppressive function and are important in inflammatory diseases. Using Tregs as biomarkers or targeting them for cardioprotective effects by regulating immune balance, suppressing inflammation, and promoting cardiac regeneration has become a research focus in CVD treatment. However, Tregs have plasticity and can lose their immunosuppressive function, causing toxic effects on target organs in certain diseases. This review provides an overview of Tregs' role in CVDs, discusses their plasticity, and lays a foundation for future studies targeting Tregs in CVD prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
America Vera-Montecinos, Jordi Galiano-Landeira, Monica Roldan, Francisco Vidal-Domenech, Enrique Claro, Belen Ramos
Summary: METTL7A is mainly located in the endoplasmic reticulum and lipid droplets, with limited cellular expression in the brain. Reduced protein levels of METTL7A have been found in schizophrenia. Our study shows that METTL7A is highly expressed in Bergmann glia and has contacts with Purkinje neurons. The localization of METTL7A may play a role in maintaining cerebellar homeostasis and modulating cerebellar circuits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Esme Jansen van Vuren, Stephan F. Steyn, Christiaan B. Brink, Marisa Moller, Francois P. Viljoen, Brian H. Harvey
Summary: Viral infections can impact pre-existing psychiatric conditions and pharmacological treatments for psychiatric disorders may affect the treatment progression of SARS-CoV-2. Inflammation plays a crucial role in many neurological and psychiatric disorders, necessitating consideration of this factor in treatment approaches.
BIOMEDICINE & PHARMACOTHERAPY
(2021)