期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 114, 期 5, 页码 2600-2615出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00097.2015
关键词
single-unit recording; head-fixed rats; Pavlovian conditioning
资金
- KAKENHI [24223004, 24243067, 19673002, 24-8027]
- Japan Society for the Promotion of Science
- Swiss National Science Foundation [PP00P1_128574, PP00P1_150739]
- Grants-in-Aid for Scientific Research [15K16569, 19673002] Funding Source: KAKEN
To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.
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