Article
Radiology, Nuclear Medicine & Medical Imaging
Miao Li, Weijun Wei, Todd E. Barnhart, Dawei Jiang, Tianye Cao, Kevin Fan, Jonathan W. Engle, Jianjun Liu, Weiyu Chen, Weibo Cai
Summary: The dual-labeled ICAM-1-targeted tracer demonstrated desirable affinity and specificity in detecting PDAC, potentially improving diagnosis and intervention upon clinical translation. The study utilized multiple noninvasive imaging approaches to validate the effectiveness of the tracer, highlighting its potential for better management of PDAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Analytical
Yunting Qu, Danni Li, Jinrui Liu, Fangkai Du, Xuecai Tan, Yuzhu Zhou, Shaogang Liu, Weihua Xu
Summary: In this study, near-infrared carbon dots were synthesized from Magnolia denudata leaves using an eco-friendly approach. The synthesized carbon dots were modified and used as a fluorescent nanoprobe for detecting palladium ion, showing high selectivity, excellent water solubility, and stability. This nanoprobe demonstrated low toxicity and could be utilized for monitoring palladium ion in real water samples and Li-7 cells.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Xujiang Yu, Aodenggerile, Zhao Jiang, Jianliang Shen, Zhiqiang Yan, Wanwan Li, Huibin Qiu
Summary: The study presents a rational design of neodymium-doped gadolinium tungstate nanoparticles that can harmoniously integrate NIR-II fluorescence imaging, CT, and MRI. The potential of rare-earth-doped NPs for multimodal imaging of different types of cancer is highlighted, demonstrating the importance of integrating newly emerged and traditional clinical imaging techniques.
Article
Biochemistry & Molecular Biology
Ying Chen, Il Minn, Steven P. Rowe, Alla Lisok, Samit Chatterjee, Mary Brummet, Sangeeta Ray Banerjee, Ronnie C. Mease, Martin G. Pomper
Summary: We have synthesized a series of near-infrared imaging agents targeting PSMA for use in fluorescence-guided surgery. The compounds were designed to improve pharmacokinetics by altering the linker between the PSMA-targeting urea moiety and the fluorophore. These compounds show potential for FGS in prostate, renal or other PSMA-expressing cancers.
Article
Nanoscience & Nanotechnology
Connor Riahin, Adam Meares, Nopondo N. Esemoto, Marcin Ptaszek, Michael LaScola, Narendra Pandala, Erin Lavik, Mengran Yang, Gary Stacey, Dehong Hu, Jeremiah C. Traeger, Galya Orr, Zeev Rosenzweig
Summary: This paper presents a method for synthesizing near-infrared emitting polymer dots (Pdots) with tunable emission peak wavelength by doping chlorins and bacteriochlorins. The doped Pdots show nearly spherical morphology with narrow emission bands. The paper demonstrates the utility of this synthesis approach and showcases the potential applications of Pdots in various fields.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding
Summary: In this paper, near-infrared carbon quantum dots (NIR-CQDs) were prepared and applied for fluorescence sensing of cortisol. NIR-CQDs-Apt can adsorb on the surface of graphene oxide (GO) and exhibit an inner filter effect (IFE). The presence of cortisol disrupts the IFE process, resulting in the recovery of NIR-CQDs-Apt fluorescence. This sensor shows excellent selectivity and a low detection limit, making it suitable for intracellular cortisol detection.
Article
Optics
Zhe Feng, Tao Tang, Tianxiang Wu, Xiaoming Yu, Yuhuang Zhang, Meng Wang, Junyan Zheng, Yanyun Ying, Siyi Chen, Jing Zhou, Xiaoxiao Fan, Shengliang Li, Mingxi Zhang, Jun Qian
Summary: The study improved the definition of the NIR-II window, proposed the NIR-III window, identified the optical range suitable for in vivo imaging, and provided excellent optical sectioning capability and imaging depth for brain fluorescence microscopy examinations.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Chemistry, Analytical
Hanyue Cui, Jing Yang, Huan Lu, Li Li, Xiaoli Zhu, Yaping Ding
Summary: A label-free fluorescence sensor based on near-infrared carbon dots and aptamer has been developed for the sensitive and selective detection of ciprofloxacin. The sensor showed excellent performance with linear response and low detection limit, and it also demonstrated great potential in biological imaging.
Article
Engineering, Environmental
Yu Long, Nannan Wei, Peizhe Yuan, Xiaoying Lv, Xiangming Song, Ziyang Zhu, Qingyao Liu, Dawei Jiang, Xiaoli Lan, Yongkang Gai
Summary: A non-invasive method of tracking γδ T cells through NIRF/PET imaging was developed using metabolic glycoengineering and bioorthogonal click chemistry. The study demonstrated that this method accurately maps the biodistribution, migration, and tumor-homing efficiency of adoptive γδ T cells in vivo, representing a new potential γδ T cell imaging technology.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Zeng Xu, Huabei Huang, Xiang Xiong, Xiaoqing Wei, Xing Guo, Jingya Zhao, Shaobing Zhou
Summary: Developed a near-infrared light-responsive extracellular vesicle nanoplatform that can deeply penetrate tumor tissues and be rapidly eliminated from the body post-treatment, enhancing therapeutic efficacy. Similar to a Trojan horse, the nanoplatform hides anti-tumor agents in macrophage cell-secreted vesicles and utilizes NIR fluorescence imaging for in vivo biodistribution monitoring.
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Article
Chemistry, Multidisciplinary
Nathan R. Paisley, Sarah Halldorson, Michael Tran, Rupsa Gupta, Saeid Kamal, W. Russ Algar, Zachary M. Hudson
Summary: Near-infrared-emitting polymers were successfully prepared via ROMP with high molecular weights and low dispersities, showing efficient emission properties. The presence of TADF and phosphorescence in different polymers was found to be related to the rotation of the donor-acceptor linker.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Cardiac & Cardiovascular Systems
Jiawen Li, Nicholas J. Montarello, Ayla Hoogendoorn, Johan W. Verjans, Christina A. Bursill, Karlheinz Peter, Stephen J. Nicholls, Robert A. McLaughlin, Peter J. Psaltis
Summary: This review examines emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation, aiming to advance clinical approaches for predicting atherothrombotic events and improving the treatment of coronary atherosclerosis.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Nanoscience & Nanotechnology
Mingfa Peng, Yang Liu, Fei Li, Xuekun Hong, Yushen Liu, Zhen Wen, Zeke Liu, Wanli Ma, Xuhui Sun
Summary: The paper introduces efficient NIR photodetectors based on the direct synthesis of PbSe quantum dot inks. By constructing the PbSe QDs/ZnO heterostructure, the photodetectors exhibit high NIR responsivity and detectivity. The in-situ passivation and the avoidance of ligand exchange have successfully improved the performance of the photodetectors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Ling Ding, Zhenbin Lyu, Teodora-Adriana Perles-Barbacaru, Adela Ya-Ting Huang, Baoping Lian, Yifan Jiang, Tom Roussel, Christina Galanakou, Suzanne Giorgio, Chai-Lin Kao, Xiaoxuan Liu, Juan Iovanna, Monique Bernard, Angele Viola, Ling Peng
Summary: Bioimaging is a powerful tool for diagnosing tumors, but it has limitations in terms of sensitivity and specificity. Nanotechnology-based imaging probes can overcome these limitations by self-assembling into nanosized imaging agents that increase the contrast of tumors and have both MRI and NIRF multimodality imaging capabilities. This study highlights the promising application of self-assembling dendrimers in multimodality imaging.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Sixiang Shi, Kai Yang, Hao Hong, Feng Chen, Hector F. Valdovinos, Shreya Goel, Todd E. Barnhart, Zhuang Liu, Weibo Cai
Article
Chemistry, Physical
Haiyan Dong, Harendra S. Parekh, Zhi Ping
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2015)
Review
Virology
Jiezhong Chen, Wenyi Gu, Lei Yang, Chen Chen, Renfu Shao, Kewei Xu, Zhi Ping Xu
REVIEWS IN MEDICAL VIROLOGY
(2015)
Article
Chemistry, Physical
Li Li, Zi Gu, Wenyi Gu, Jian Liu, Zhi Ping Xu
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2016)
Article
Virology
Neena Mitter, Elizabeth A. Worrall, Karl E. Robinson, Zhi Ping Xu, Bernard J. Carroll
CURRENT OPINION IN VIROLOGY
(2017)
Article
Chemistry, Physical
Li Li, Wenyi Gu, Jian Liu, Shiyu Yan, Zhi Ping Xu
Article
Chemistry, Multidisciplinary
Xiaowen Liang, Jeffrey E. Grice, Yian Zhu, David Liu, Washington Y. Sanchez, Zhen Li, Darrell H. G. Crawford, David G. Le Couteur, Victoria C. Cogger, Xin Liu, Zhi Ping Xu, Michael S. Roberts
Article
Pharmacology & Pharmacy
Haolu Wang, Haotian Yang, Zhi Ping Xu, Xin Liu, Michael S. Roberts, Xiaowen Liang
Article
Chemistry, Multidisciplinary
Yanheng Wu, Wenyi Gu, Li Li, Chen Chen, Zhi Ping Xu
Review
Oncology
Yuchen Jin, Beibei Liu, Muhsin H. Younis, Gang Huang, Jianjun Liu, Weibo Cai, Weijun Wei
Summary: Molecular imaging utilizes radionuclides or artificially modified molecules to image specific disease targets, with newly developed probes enabling target-specific diagnosis and treatment of diseases. Advances in molecular imaging have led to the development of novel tracers based on aptamer, peptide, antibody, nanobody, antibody fragment, and nanoparticle platforms, supporting the management of diseases such as thyroid cancer.
Review
Oncology
Huiling Li, Zhen Liu, Lujie Yuan, Kevin Fan, Yongxue Zhang, Weibo Cai, Xiaoli Lan
Summary: Breast cancer is a common malignant tumor that affects women globally, posing a significant threat to their health. Early detection of breast cancer can greatly improve patient prognosis and survival rates, with radionuclide molecular imaging techniques offering advantages in functional detection. Using radionuclide-labeled compounds for noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualizing overexpressed molecular markers in the disease, aiding in early diagnosis and improved patient care. Rapid developments in radionuclide probes are contributing to the diagnosis of breast cancer across various aspects, with promising tools being developed for early detection.
Article
Pharmacology & Pharmacy
Fatemeh Movahedi, Jie Liu, Bing Sun, Pei Cao, Luyao Sun, Christopher Howard, Wenyi Gu, Zhi Ping Xu
Summary: Co-loaded dual-targeting LCP nanoparticles with ABZ and OTS show synergistic cytotoxicity against skin cancer cells and completely suppress skin tumor growth at low doses through targeting PD-L1 and folate receptor.
Article
Cell Biology
Qianling Su, Wei Shi, Xianing Huang, Yakun Wan, Guanghui Li, Bengang Xing, Zhi Ping Xu, Hongbo Liu, Bruce D. Hammock, Xiaomei Yang, Shihua Yin, Xiaoling Lu
Summary: This study successfully developed four nanobody strains with significant affinity and specificity against SARS-CoV-2 spike protein receptor binding domain. These findings provide an important foundation for further research and the development of diagnostic and therapeutic tools for SARS-CoV-2.
Article
Chemistry, Multidisciplinary
Bei Li, Zi Gu, Nyoman Kurniawan, Weiyu Chen, Zhi Ping Xu
ADVANCED MATERIALS
(2017)
Article
Nanoscience & Nanotechnology
Huali Zuo, Weiyu Chen, Helen M. Cooper, Zhi Ping Xu
ACS APPLIED MATERIALS & INTERFACES
(2017)