Article
Multidisciplinary Sciences
Tina Perica, Christopher J. P. Mathy, Jiewei Xu, Gwendolyn M. Jang, Yang Zhang, Robyn Kaake, Noah Ollikainen, Hannes Braberg, Danielle L. Swaney, David G. Lambright, Mark J. S. Kelly, Nevan J. Krogan, Tanja Kortemme
Summary: This study reveals that the functional specificity of the small GTPase switch protein Gsp1 in Saccharomyces cerevisiae is linked to the differential sensitivity of biological processes to different kinetics of the Gsp1 switch cycle. By making targeted point mutations to individual protein interaction interfaces of Gsp1 and conducting quantitative genetic and physical interaction mapping, it is shown that interface mutations allosterically tune the GTPase cycle kinetics, rather than grouping by targeted interfaces. These findings suggest a model in which protein partner binding or post-translational modifications may act as allosteric regulators of GTPase switching and may have implications for disease mutations targeting central molecular switches.
Review
Pharmacology & Pharmacy
Mrinmoyee Majumder, Paramita Chakraborty, Sarumathi Mohan, Shikhar Mehrotra, Viswanathan Palanisamy
Summary: The control of eukaryotic gene expression occurs at multiple levels, and RNA-binding proteins, such as HuR, play crucial roles in regulating mRNA processing and stability. HuR overexpression is linked to various diseases, including cancer, making it an appealing target for drug development. This article reviews the current prospects and mode of action of drugs targeting HuR in cancer treatment, highlighting the significance of HuR overexpression and its role in immune functions.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Oncology
Monika Pliszka, Leszek Szablewski
Summary: Cancer cells prefer glycolysis for ATP production due to hypoxia; overexpression of glucose transporters promotes carcinogenesis and may have beneficial effects; inhibiting glucose transporters could be a treatment method for cancer patients.
Review
Biochemistry & Molecular Biology
Mengyi Lao, Xiaozhen Zhang, Hanshen Yang, Xueli Bai, Tingbo Liang
Summary: This review highlights the crucial role of regulator of calcineurin 1 (RCAN1) in the pathogenesis of cancer and its interaction with calcineurin. High expression of RCAN1 inhibits tumor progression, except for hypopharyngeal and laryngopharynx cancer. Therefore, targeting RCAN1 may be a promising therapeutic approach for cancer treatment.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Huaiping Cui, Zhaoyu Jiang, Shujie Zeng, Hao Wu, Zihao Zhang, Xiaobo Guo, Kangdi Dong, Jinshen Wang, Liang Shang, Leping Li
Summary: In this study, a novel lncRNA WFDC21P derived from pseudogenes was identified and found to promote proliferation and metastasis of gastric cancer cells by activating the Akt/GSK3 beta/beta-catenin pathway. It may serve as a potential biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Vincent Sauzeau, Julien Beignet, Christian Bailly
Summary: Bladder pathologies, commonly seen in the aged population, have a significant negative impact on quality of life. Novel targets like Rac1 show promise in treating diseases such as overactive bladder and bladder cancers. Small molecules targeting Rac1 have been discovered or designed and have exhibited activity against bladder cancer, suggesting potential for better management of bladder pathologies.
Review
Chemistry, Medicinal
Huan Xiao, Guan Wang, Min Zhao, Wen Shuai, Liang Ouyang, Qiu Sun
Summary: This review mainly summarizes the important role of GAPs in human tumors by introducing their classification, function, and regulatory mechanism. The relationship between dysregulated GAPs and a certain type of tumor is comprehensively described. In addition, the current status, research progress, and clinical value of GAPs as therapeutic targets, as well as the challenges and future direction in cancer therapy, are discussed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Francesca Battaglin, Priscilla Chan, Yuanzhong Pan, Shivani Soni, Meng Qu, Erin R. Spiller, Sofi Castanon, Evanthia T. Roussos Torres, Shannon M. Mumenthaler, Steve A. Kay, Heinz-Josef Lenz
Summary: Disruption of the circadian clock pathway is associated with cancer risk, development, and progression. Dysregulation of core circadian clock genes is common in human tumors, with varied effects and mechanisms depending on cancer types. Pharmacological modulation of clock components shows promise as a novel anti-cancer therapeutic approach.
Review
Pharmacology & Pharmacy
Christian Bailly, Julien Beignet, Gervaise Loirand, Vincent Sauzeau
Summary: GTPase Rac1 plays important roles in multiple cellular processes and is considered a potential target for the treatment of various diseases. Potent and selective Rac1 inhibitors have been identified, showing promise in cancer treatment. However, the wide expression and multiple functions of Rac1 also pose limitations to its application.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Guo Chen, Banghe Bao, Yang Cheng, Minxiu Tian, Jiyu Song, Liduan Zheng, Qiangsong Tong
Summary: Acetyl-CoA plays a crucial role in cellular metabolism and is involved in cancer development and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yi Xiao, Dihua Yu
Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cell Biology
Imge Ozugergin, Karina Mastronardi, Chris Law, Alisa Piekny
Summary: This study uncovers the different cytokinesis kinetics and regulation mechanisms in AB cells and P-1 cells in Caenorhabditis elegans embryos.
JOURNAL OF CELL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Article
Biochemistry & Molecular Biology
Severin Lechner, Martin Ian P. Malgapo, Christian Graetz, Raphael R. Steimbach, Agnes Baron, Patrick Ruether, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Wuerf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Kuster, Guillaume Medard
Summary: This study used a quantitative chemical proteomics assay to investigate the target landscape of 53 drugs that target HDAC. The results questioned the selectivity of some widely-used molecules and revealed the influence of HDAC complex composition on drug potency. Additionally, the study identified MBLAC2 as a frequent off-target of hydroxamate drugs and suggested it as a potential target for drug discovery due to its involvement in extracellular vesicle accumulation.
NATURE CHEMICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anwar Salem, Mashael Alotaibi, Rima Mroueh, Haneen A. Basheer, Kamyar Afarinkia
Summary: The CCR7 chemokine axis plays dual roles in cancer, with potential to enhance immune response to tumors while also contributing to tumor cell migration and metastasis. The balance between these opposing effects presents challenges and opportunities for targeted cancer therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
