Article
Oncology
Maria Sol Recouvreux, Jiangyong Miao, Maricel C. Gozo, Jingni Wu, Ann E. Walts, Beth Y. Karlan, Sandra Orsulic
Summary: Tumors require a continuous supply of oxygen and nutrients for growth, and vasculogenic mimicry is a coping mechanism where cancer cells form vascular-like structures. FOXC2 gene expression is associated with vasculogenic mimicry and aggressive cancer behavior.
Article
Chemistry, Medicinal
Songtao Dong, Zhongyuan Chen, Li Wang, Yankai Liu, Dimitrios Stagos, Xiukun Lin, Ming Liu
Summary: BTDE, a marine algae-derived compound, demonstrates anti-angiogenesis effects by inhibiting endothelial cell activity and affecting functions of tumor cells, indicating its potential value in anti-cancer therapy through targeting angiogenesis.
Review
Cell Biology
Fengkai Li, Jiahui Xu, Suling Liu
Summary: Cancer stem cells play crucial roles in tumor-associated angiogenesis, contributing to tumor progression and metastasis through various pathways. Understanding these mechanisms is essential for developing more efficient therapeutic approaches for cancer treatment.
Review
Biochemistry & Molecular Biology
Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng
Summary: Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.
Review
Oncology
Kelsey Maddison, Nikola A. Bowden, Moira C. Graves, Paul A. Tooney
Summary: This study aimed to determine the markers consistently attributed to vasculogenic mimicry (VM) and tumour to endothelial transdifferentiation in glioblastoma. It was found that VM lacks expression of CD34 and/or CD31, while tumour to endothelial transdifferentiation expresses CD34 and/or CD31 in addition to other endothelial, stem cell, or tumour cell markers. Further research and characterization of this process are needed.
Review
Biochemistry & Molecular Biology
Ana K. Herrera-Vargas, Eduardo Garcia-Rodriguez, Monserrat Olea-Flores, Miguel A. Mendoza-Catalan, Eugenia Flores-Alfaro, Napoleon Navarro-Tito
Summary: The ability of leptin to induce angiogenesis and vasculogenic mimicry in different types of cancer has been studied, with significant relationships observed in breast cancer. Leptin activates multiple pathways to promote the expression of angiogenic factors and vasculogenic mimicry, suggesting its potential role as a therapeutic target for tumor survival and metastasis.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Review
Oncology
Xinyu Lin, Sheng Long, Congcong Yan, Xiaofeng Zou, Guoxi Zhang, Junrong Zou, Gengqing Wu
Summary: Angiogenesis is a crucial process in cancer growth and metastasis, but its inhibition can lead to acquired resistance. Vasculogenic mimicry is an alternative mechanism of tumor angiogenesis and is associated with poor prognosis. Inhibiting vasculogenic mimicry may be an effective therapeutic strategy to overcome the limitations of anti-angiogenic treatment when used in combination with other anti-tumor therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Nazila Fathi Maroufi, Mohsen Rashidi, Vahid Vahedian, Raheleh Jahanbazi, Sahar Mostafaei, Maryam Akbarzadeh, Hamid Kazemzadeh, Hamid-Reza Nejabati, Alireza Isazadeh, Mohammad-Reza Rashidi, Mohammad Nouri
Summary: Melatonin and Apatinib can reduce the survival rate of CSCs and inhibit proliferation, invasion, and formation of VM in breast cancer cells. The combination of Apatinib/melatonin shows promising potential in managing patients with breast cancer. Further studies are needed to understand the anti-cancer mechanisms of melatonin and Apatinib for better patient management.
Article
Biochemistry & Molecular Biology
Sara Peri, Alessio Biagioni, Giampaolo Versienti, Elena Andreucci, Fabio Staderini, Giuseppe Barbato, Lisa Giovannelli, Francesco Coratti, Nicola Schiavone, Fabio Cianchi, Laura Papucci, Lucia Magnelli
Summary: Chemotherapy is widely used in gastric cancer treatment as an adjuvant when surgery is not feasible or in the presence of metastasis. Chemoresistance is a major challenge in cancer therapy, leading to tumor recurrence and treatment failure. Despite known mechanisms of chemoresistance, a universal marker for chemoresistant cancer cells has not yet been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Zhenxing Liang, Huashan Liu, Yunfeng Zhang, Li Xiong, Ziwei Zeng, Xiaowen He, Fengwei Wang, Xianrui Wu, Ping Lan
Summary: ADSC-derived Cyr61 plays a critical role in promoting CRC progression via integrin alpha(V)beta(5), facilitating cancer cell metastasis and tumor growth. Targeting Cyr61/alpha(V)beta(5) pathway offers a novel antitumor strategy.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Ada Nowosad, Jean-Christophe Marine, Panagiotis Karras
Summary: Tumors are complex ecosystems consisting of cancer cells and immune cells, which communicate bidirectionally and influence tumor growth and metastasis. The tumor vasculature and perivascular niche play important roles in promoting cancer stemness, immune evasion, dormancy, and metastatic spreading. These findings have significant implications for cancer research and therapy.
Article
Oncology
Fangzhu Wan, Haojiong Zhang, Jiyi Hu, Li Chen, Shikai Geng, Lin Kong, Jiade J. Lu
Summary: This study identified miR-125a as highly expressed in normal nasopharyngeal epithelial tissue compared to nasopharyngeal carcinoma. It demonstrated that miR-125a inhibits the migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells, targeting TAZ. Additionally, artificial engineering of mesenchymal stem cells (MSCs) allowed the generation of miR-125a-overexpressing exosomes which attenuated VM formation and migration in nasopharyngeal carcinoma, providing a potential therapeutic approach.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Deok-Soo Han, Eun-Ok Lee
Summary: This study investigated the crucial role of Sp1 in the process of vasculogenic mimicry (VM) in human prostate cancer cells. The results demonstrated that Sp1 mediates VM formation through interacting with the twist/VE-cadherin/AKT pathway in human PCa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Maria J. Ibarra-Sanchez, Jose Esparza-Lopez, Rocio Garcia-Becerra, Fernando Larrea, Lorenza Diaz
Summary: This study investigates the role of endothelial cells in vasculogenic mimicry (VM) in triple-negative breast cancer (TNBC) and the involvement of the FGFR/PI3K/Akt pathway. Results show that endothelial cells play a predominant role in inducing VM, and the FGFR/PI3K/Akt pathway is implicated in this process. Targeting this pathway may hold promise for treating and preventing VM in TNBC tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xianwen Ren, Wen Wen, Xiaoying Fan, Wenhong Hou, Bin Su, Pengfei Cai, Jiesheng Li, Yang Liu, Fei Tang, Fan Zhang, Yu Yang, Jiangping He, Wenji Ma, Jingjing He, Pingping Wang, Qiqi Cao, Fangjin Chen, Yuqing Chen, Xuelian Cheng, Guohong Deng, Xilong Deng, Wenyu Ding, Yingmei Feng, Rui Gan, Chuang Guo, Weiqiang Guo, Shuai He, Chen Jiang, Juanran Liang, Yi-min Li, Jun Lin, Yun Ling, Haofei Liu, Jianwei Liu, Nianping Liu, Shu-Qiang Liu, Meng Luo, Qiang Ma, Qibing Song, Wujianan Sun, GaoXiang Wang, Feng Wang, Ying Wang, Xiaofeng Wen, Qian Wu, Gang Xu, Xiaowei Xie, Xinxin Xiong, Xudong Xing, Hao Xu, Chonghai Yin, Dongdong Yu, Kezhuo Yu, Jin Yuan, Biao Zhang, Peipei Zhang, Tong Zhang, Jincun Zhao, Peidong Zhao, Jianfeng Zhou, Wei Zhou, Sujuan Zhong, Xiaosong Zhong, Shuye Zhang, Lin Zhu, Ping Zhu, Bin Zou, Jiahua Zou, Zengtao Zuo, Fan Bai, Xi Huang, Penghui Zhou, Qinghua Jiang, Zhiwei Huang, Jin-Xin Bei, Lai Wei, Xiu-Wu Bian, Xindong Liu, Tao Cheng, Xiangpan Li, Pingsen Zhao, Fu-Sheng Wang, Hongyang Wang, Bing Su, Zheng Zhang, Kun Qu, Xiaoqun Wang, Jiekai Chen, Ronghua Jin, Zemin Zhang
Summary: The study revealed the presence of immune response dysfunction in COVID-19 patients, with different peripheral immune subtype changes associated with clinical features such as age, sex, severity, and disease stages. Additionally, dramatic transcriptomic changes were observed within virus-infected cells, and upregulation of S100A8/A9 in peripheral blood may contribute to the cytokine storms frequently observed in severe patients.
Article
Biochemistry & Molecular Biology
Zhengrong Zhang, You Zheng, Zubiao Niu, Bo Zhang, Chenxi Wang, Xiaohong Yao, Haoran Peng, Del Nonno Franca, Yunyun Wang, Yichao Zhu, Yan Su, Meng Tang, Xiaoyi Jiang, He Ren, Meifang He, Yuqi Wang, Lihua Gao, Ping Zhao, Hanping Shi, Zhaolie Chen, Xiaoning Wang, Mauro Piacentini, Xiuwu Bian, Gerry Melino, Liang Liu, Hongyan Huang, Qiang Sun
Summary: In COVID-19 patients, SARS-CoV-2 infection leads to the presence of heterotypic cell-in-cell structures in lung tissues with lymphocytes inside multinucleate syncytia. The membrane fusion induced by the spike glycoprotein is controlled by a bi-arginine motif, and candidate anti-viral drugs can efficiently inhibit this process. This study provides insights into the molecular and cellular mechanisms of SARS-CoV-2 pathogenesis and identifies potential novel targets for COVID-19 therapy.
CELL DEATH AND DIFFERENTIATION
(2021)
Editorial Material
Immunology
Jinghe Zhang, Haibo Wu, XiaoHong Yao, Dingyu Zhang, Yonggang Zhou, Binqing Fu, Wei Wang, Heng Li, Zhe Wang, Ziming Hu, Yong Ren, Rui Sun, Zhigang Tian, Xiuwu Bian, Haiming Wei
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Weiqi Dang, Jingfang Xiao, Qinghua Ma, Jingya Miao, Mianfu Cao, Lu Chen, Yu Shi, Xiaohong Yao, Shichang Yu, Xindong Liu, Youhong Cui, Xia Zhang, Xiuwu Bian
Summary: The study demonstrates that a p38MAPK inhibitor can reduce macrophages/microglia accumulation in glioma and prolong the survivals of glioma-bearing mice, potentially through inhibiting PD-L1 expression. The combination therapy of p38MAPK inhibitor with PD-L1 antibody effectively prolongs the survivals of TMZ-resistant GBM-bearing hosts and modulates the immune microenvironment within the tumor. Further clinical studies are needed to confirm the safety and efficacy of this combination therapy.
BRAIN TUMOR PATHOLOGY
(2021)
Article
Cell Biology
Xiao-Hong Yao, Tao Luo, Yu Shi, Zhi-Cheng He, Rui Tang, Pei-Pei Zhang, Jun Cai, Xiang-Dong Zhou, Dong-Po Jiang, Xiao-Chun Fei, Xue-Quan Huang, Lei Zhao, Heng Zhang, Hai-Bo Wu, Yong Ren, Zhen-Hua Liu, Hua-Rong Zhang, Cong Chen, Wen-Juan Fu, Heng Li, Xin-Yi Xia, Rong Chen, Yan Wang, Xin-Dong Liu, Chang-Lin Yin, Ze-Xuan Yan, Juan Wang, Rui Jing, Tai-Sheng Li, Wei-Qin Li, Chao-Fu Wang, Yan-Qing Ding, Qing Mao, Ding-Yu Zhang, Shu-Yang Zhang, Yi-Fang Ping, Xiu-Wu Bian
Summary: The study profiles 26 COVID-19 autopsy cases from Wuhan and determines the systemic distribution of SARS-CoV-2 in critically ill patients. It reveals that SARS-CoV-2 may invade multiple organs and utilize physiological barriers as entry ports for systemic dissemination, shedding light on novel COVID-19 treatment development.
Article
Cell Biology
Xiao-Ning Zhang, Kai-Di Yang, Cong Chen, Zhi-Cheng He, Qiang-Hu Wang, Hua Feng, Sheng-Qing Lv, Yan Wang, Min Mao, Qing Liu, Yao-Yao Tan, Wen-Ying Wang, Tian-Ran Li, Lin-Rong Che, Zhong-Yi Qin, Ling-Xiang Wu, Min Luo, Chun-Hua Luo, Yu-Qi Liu, Wen Yin, Chao Wang, Hai-Tao Guo, Qing-Rui Li, Bin Wang, Wei Chen, Shuang Wang, Yu Shi, Xiu-Wu Bian, Yi-Fang Ping
Summary: The study reveals the role of pericytes in potentiating DDR signaling in GBM cells, and suggests that targeting CCL5-CCR5 signaling could be an effective therapeutic strategy to improve chemotherapeutic efficacy against GBM.
Meeting Abstract
Oncology
Qiyun Shi, Juncheng Xuhong, Jia Ge, Feng Liu, Yang Lan, Yi Zhang, Tao Luo, Xiuwu Bian, Xiaowei Qi, Jun Jiang
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Zheng Zhu, Jiao Wang, Juan Tan, Yue-Liang Yao, Zhi-Cheng He, Xiao-Qing Xie, Ze-Xuan Yan, Wen-Juan Fu, Qing Liu, Yan-Xia Wang, Tao Luo, Xiu-Wu Bian
Summary: The study revealed that high expression of CAPS in glioma is associated with poor survival. CAPS promotes glioma proliferation by regulating the cell cycle and interacts with MYPT1 to affect PLK1 phosphorylation. The PLK1 inhibitor volasertib enhances the therapeutic effect of temozolomide in glioma.
JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiahui Xu, Xiaoli Yang, Qiaodan Deng, Cong Yang, Dong Wang, Guojuan Jiang, Xiaohong Yao, Xueyan He, Jiajun Ding, Jiankun Qiang, Juchuanli Tu, Rui Zhang, Qun-Ying Lei, Zhi-min Shao, Xiuwu Bian, Ronggui Hu, Lixing Zhang, Suling Liu
Summary: Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the development of triple-negative breast cancer (TNBC). We identified TEM8 as a functional marker for VM-forming BTICs in TNBC, providing a target for the development of effective therapies against TNBC targeting both BTIC self-renewal and neovasculogenesis simultaneously. TEM8 promotes stemness and VM differentiation capacity through a RhoC/ROCK1/SMAD5 axis.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Min Luo, Yu-Qi Liu, Hua Zhang, Chun-Hua Luo, Qing Liu, Wen-Ying Wang, Zhi-Cheng He, Cong Chen, Xiao-Ning Zhang, Min Mao, Kai-Di Yang, Chao Wang, Xiao-Qing Chen, Wen-Juan Fu, Qin Niu, Xiu-Wu Bian, Yu Shi, Yi-Fang Ping
Summary: The study demonstrates that CPT1A plays a critical role in regulating mitochondrial dynamics and GSC differentiation in glioblastoma. Overexpression of CPT1A inhibits GSC self-renewal and promotes mitochondrial fusion, while disruption of CPT1A leads to mitochondrial fission and reprogramming of non-stem tumor cells towards GSC features. This suggests that CPT1A could be a potential target for differentiation therapy in GBM.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Kaidi Yang, Yu Shi, Min Luo, Min Mao, Xiaoning Zhang, Cong Chen, Yuqi Liu, Zhicheng He, Qing Liu, Wenying Wang, Chunhua Luo, Wen Yin, Chao Wang, Qin Niu, Hui Zeng, Xiu-Wu Bian, Yi-Fang Ping
Summary: This study used single-cell RNA sequencing and bulk RNA sequencing data to reveal the immune evasion mechanisms of GBM cells and their interactions with immune cells. A new subset of GBM cells, TC-6, was identified with immune-invading characteristics and synergy with tumor-associated macrophages to create an immune-suppressive environment. Three immune subtypes were also identified, with C3 GBMs being enriched with TC-6 cells and immunosuppressive macrophages, which were associated with reduced efficacy of anti-PD-1 treatment. The findings provide new insights into optimizing anti-GBM immunotherapy.
Article
Materials Science, Multidisciplinary
Kai Wang, Shuaishuai Ding, Lijuan Zeng, Jingrong Zhou, Yuhua Cao, Jiaqian Wu, Lu Lu, Xiu-wu Bian, Gan Tian
Summary: A dual exogenous/endogenous CA IX inhibition strategy using metal-organic framework/gold nanoparticles nanohybrids was developed for hypoxia-relief enhanced radiation therapy of triple negative breast cancer. This strategy effectively alleviated hypoxia-induced resistance by combining external and internal inhibition methods, along with radiotherapy, to achieve a synergistic therapeutic outcome.
APPLIED MATERIALS TODAY
(2021)
Article
Cell Biology
Li-Hong Wang, Sen Wei, Ye Yuan, Ming-Jun Zhong, Jiao Wang, Ze-Xuan Yan, Kai Zhou, Tao Luo, Li Liang, Xiu-Wu Bian
Summary: PARP inhibitors have limited efficacy when used alone in glioblastoma (GBM) patients, leading researchers to explore combination therapies. This study found that concurrent treatment with the PARP inhibitor olaparib and XPO1 inhibitor KPT330 showed synergistic anticancer effects on GBM cells. Mechanistically, KPT330 induced the nuclear retention of SQSTM1 and inhibited the ubiquitination of the DNA repair signal H2AX mediated by olaparib in the nucleus, inhibiting DNA damage response and repair in GBM. In the cytoplasm, KPT330 blocked autophagic flux and induced dysfunction of lysosomes, ultimately promoting cell death.
Article
Oncology
Juan Feng, Yang Lan, Feng Liu, Ye Yuan, Jia Ge, Sen Wei, Hu Luo, Jianjun Li, Tao Luo, Xiuwu Bian
Summary: The genomic instability/homologous recombination deficiency (GI/HRD) score has prognostic value in lung adenocarcinoma, particularly when combined with TP53 status, but is not applicable for all types of lung cancer.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qu-Jing Gai, Zhen Fu, Jiang He, Min Mao, Xiao-Xue Yao, Yan Qin, Xi Lan, Lin Zhang, Jing-Ya Miao, Yan-Xia Wang, Jiang Zhu, Fei-Cheng Yang, Hui-Min Lu, Ze-Xuan Yan, Fang-Lin Chen, Yu Shi, Yi-Fang Ping, You-Hong Cui, Xia Zhang, Xindong Liu, Xiao-Hong Yao, Sheng-Qing Lv, Xiu-Wu Bian, Yan Wang
Summary: PDGFRA may not be necessary for PDGFA function. The study revealed EPHA2 as a potential receptor of PDGFA and identified that co-upregulation of PDGFA and EPHA2 led to worse patient prognosis and poorer therapeutic effects. Combination inhibitors targeting PDGFRA and EHA2 represent a promising therapeutic strategy for GBM treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
