Article
Infectious Diseases
Fahad M. Alsaab, Scott N. Dean, Shravani Bobde, Gabriel G. Ascoli, Monique L. van Hoek
Summary: In this study, a series of novel antimicrobial peptides (AMPs) named HRZN were designed using a computational approach to target multidrug-resistant Acinetobacter baumannii. HRZN-15 showed the highest antimicrobial activity and exhibited membrane permeabilization and depolarization. Further modification of HRZN-15 could lead to a new peptide with improved toxicity profile.
Article
Nutrition & Dietetics
Juliana Garcia, Francisca Rodrigues, Flavia Castro, Alfredo Aires, Guilhermina Marques, Maria Jose Saavedra
Summary: The aqueous and methanolic extracts of Boletus edulis and Neoboletus luridiformis have antimicrobial and antibiofilm properties against multidrug-resistant bacteria, possibly due to the presence of phenolic compounds.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Viorica Patrulea, Bee-Ha Gan, Karl Perron, Xingguang Cai, Philippe Abdel-Sayed, Emmanuelle Sublet, Verena Ducret, Natalia Porroche Nerhot, Lee Ann Applegate, Gerrit Borchard, Jean-Louis Reymond, Olivier Jordan
Summary: We report a new chemical platform for coupling chitosan derivatives to antimicrobial peptide dendrimers, which enables synergistic antimicrobial activity and preservation of activity when incorporated into various biopolymer formulations. This platform could be used for the development of new membrane disruptive therapeutics to eradicate pathogens in wounds.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Lutfur Rahman, Yasra Sarwar, Shazia Khaliq, Wasim Inayatullah, Wasim Abbas, Ameena Mobeen, Ata Ullah, Syed Zajif Hussain, Waheed S. Khan, Maria-Eleni Kyriazi, Irshad Hussain, Antonios G. Kanaras, Asma Rehman
Summary: In this study, surfactin-coated silver nanoparticles were synthesized and applied for the first time as an efficient antibacterial and antibiofilm agent against drug-resistant bacteria. The nanoparticles showed excellent bactericidal and antibiofilm activity against Pseudomonas aeruginosa, without causing significant dermal irritation or inflammation in vivo. Microscopic analysis also revealed no pathological alterations at the applied concentrations, supporting the potential use of these nanoparticles in combating drug-resistant bacterial biofilms and for skin wound dressings.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Maria Angelica de Sa Assis, Lucas de Paula Ramos, Amjad Abu Hasna, Talita Suelen de Queiroz, Thais Cristine Pereira, Patricia Michelle Nagai de Lima, Andresa Aparecida Berretta, Maria Cristina Marcucci, Claudio Antonio Talge Carvalho, Luciane Dias de Oliveira
Summary: Brazilian green propolis aqueous extract has antimicrobial and antibiofilm effects against dental anaerobic bacteria.
Article
Chemistry, Multidisciplinary
Manvi Singh, Abdul Rehman, Nazia Hassan, Abdul Anfey Faheem, Ayan Das, Mohammad Akhlaquer Rahman, Mohammad Javed Ansari, Nilima Sharma, Mridu Dudeja, Mohd Aqil, Mohd Aamir Mirza, Zeenat Iqbal
Summary: A ciprofloxacin-loaded water-in-oil nanoemulsion (CPX-NE) was prepared and evaluated for its antimicrobial effect against oral biofilms produced by Enterococcus faecalis. The CPX-NE showed optimal rheological parameters, similar pH to the oral cavity, uniform spherical nanodroplets with narrow size distribution and stable charge. In vitro drug release demonstrated sustained release for 48 hours. CPX-NE exhibited significant inhibitory and eradication effect compared to the plain drug solution. Therefore, CPX-NE has effective antibiofilm activity against E. faecalis and may be useful in the prevention and treatment of dental caries.
Article
Pharmacology & Pharmacy
Jong-Kook Lee, Soyoung Park, Young-Min Kim, Taeuk Guk, Min-Young Lee, Seong-Cheol Park, Jung Ro Lee, Mi-Kyeong Jang
Summary: This study identified a peptide with antifungal and antibiofilm effects as a potential agent against Candida albicans on contact lenses.
Article
Chemistry, Multidisciplinary
Manvi Singh, Abdul Rehman, Nazia Hassan, Abdul Anfey Faheem, Ayan Das, MohammadAkhlaquer Rahman, Mohammad Javed Ansari, Nilima Sharma, Mridu Dudeja, Mohd Aqil, Mohd. Aamir Mirza, Zeenat Iqbal
Summary: A ciprofloxacin-loaded nanoemulsion was prepared and found to have effective antimicrobial activity against oral biofilms produced by Enterococcus faecalis, suggesting potential applications in the prevention and treatment of dental caries.
Article
Infectious Diseases
Miriam E. van Gent, Tanny J. K. van der Reijden, Patrick R. Lennard, Adriette W. de Visser, Bep Schonkeren-Ravensbergen, Natasja Dolezal, Robert A. Cordfunke, Jan Wouter Drijfhout, Peter H. Nibbering
Summary: Using a deep learning approach, researchers discovered a new antibiotic called halicin. Their study compared the effectiveness of halicin with a synthetic antibacterial and antibiofilm peptide (SAAP)-148 in killing antimicrobial-resistant bacteria like Escherichia coli, Acinetobacter baumannii, and Staphylococcus aureus. While SAAP-148 outperformed halicin in killing planktonic bacteria in biologically relevant media and 3D human infection models, both agents showed equal effectiveness against bacteria residing in biofilms. Additionally, the study revealed potential synergistic and additive interactions between SAAP-148 and halicin, making their combination a promising treatment for infections that are not effectively treatable with current antibiotics.
Article
Medicine, Research & Experimental
Aaron P. Decker, Yajuan Su, Biswajit Mishra, Atul Verma, Tamara Lushnikova, Jingwei Xie, Guangshun Wang
Summary: This study investigates the effects of peptide stability on antimicrobial and antibiofilm activity and finds that peptide antimicrobial activity is critical for in vivo efficacy. Using a nanofiber/microneedle delivery device can protect peptides from degradation and provide a new approach for direct use of natural peptides or their cocktails for antimicrobial treatment.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Sonia Gera, Esko Kankuri, Karin Kogermann
Summary: Antimicrobial peptides (AMPs) are potent broad-spectrum antimicrobials that are produced by all organisms and have additional benefits in modulating inflammatory and immune responses as well as promoting wound healing. Recent advances in nanotechnology allow for the controlled delivery of AMPs, overcoming their limitations in stability and toxicity. This review focuses on the potential therapeutic applications of AMPs in treating chronic hard-to-heal wounds using nanocarriers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Huimin Duan, Xiangmin Zhang, Zhi Li, Jianrui Yuan, Fangwang Shen, Shicui Zhang
Summary: The study demonstrates the synergistic antibacterial effect between the AMP Pt5-1c derived from phosvitin and traditional antibiotics against multidrug-resistant bacteria. It also suggests the potential of using Pt5-1c to prolong the efficacy of certain antibiotics under threat of antibiotic resistance.
MICROBIAL PATHOGENESIS
(2021)
Article
Biotechnology & Applied Microbiology
Guixi Wang, Zhizhi Chen, Pan Tian, Qinqin Han, Jinyang Zhang, A-Mei Zhang, Yuzhu Song
Summary: Cathelicidin-DM promotes cell proliferation and migration by activating the MAPK signaling pathway, facilitating wound healing. In animal experiments, it accelerates skin wound healing and early debridement, suggesting a new approach for treating infected chronic wounds.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Prakash Kishore Hazam, Chin-Cheng Cheng, Chu-Yi Hsieh, Wen-Chun Lin, Po-Hsien Hsu, Te-Li Chen, Yi-Tzu Lee, Jyh-Yih Chen
Summary: Pathogenic superbugs are causing complex infections that cannot be treated effectively. Developing novel antibacterial agents, such as antimicrobial peptides (AMPs), is urgently needed. This study successfully developed two TP2-based AMPs that showed significant antimicrobial activity against multidrug-resistant bacteria and low cytotoxicity. These peptides also demonstrated synergistic effects when combined with clinical antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yiyi Huang, Tingyu Wang, Yucong Chen, Huancai Lin, Dongru Chen
Summary: This study selected the most stable amyloid hexapeptide GIDLKI (GI6) to inhibit biofilm formation by multiple species of bacteria, including the cariogenic bacterium Streptococcus mutans. The results showed that GI6 effectively prevented and alleviated the development of dental caries without adverse effects on other organs in the body.
JOURNAL OF DENTISTRY
(2023)