Article
Biochemistry & Molecular Biology
Hanbeen Kim, Jakyeom Seo
Summary: Two potential endolysins were identified, with one showing better efficacy against MRSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Feng Wang, Yao Xiao, Yao Lu, Zheng-Yu Deng, Xian-Yu Deng, Lian-Bing Lin
Summary: This study reports a lytic enzyme, P9ly, derived from a bacteriophage that can infect multidrug-resistant bacteria. P9ly can digest bacterial cell walls and exhibits bacteriolytic and bactericidal activity on different strains. The combined use of P9ly with ceftriaxone sodium improves the antibacterial effect.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Chanyoung Lee, Jinwoo Kim, Bokyung Son, Sangryeol Ryu
Summary: By swapping different domains of natural Staphylococcus endolysins, a novel chimeric endolysin ClyC was constructed, showing enhanced lytic activity against S. aureus, strong antibacterial effects in milk and blood, and effective eradication of biofilms of multidrug-resistant bacteria. The chimeric endolysin also demonstrated protection against MRSA in a mouse infection model, suggesting its potential as an antibacterial agent against multidrug-resistant S. aureus.
ACS INFECTIOUS DISEASES
(2021)
Review
Chemistry, Medicinal
Namita Sharma, Anil Kumar Chhillar, Sweety Dahiya, Aruna Punia, Pooja Choudhary, Prity Gulia, Akanksha Behl, Mehak Dangi
Summary: Staphylococcus aureus is a dangerous human pathogen that is becoming increasingly drug resistant. Various chemotherapeutic strategies, including combination therapy, phage endolysin therapy, lysostaphin, and antibacterial drones, are emerging as alternatives to combat these drug-resistant strains. However, implementing and understanding these strategies remains a challenge.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Yifei Lu, Yingran Wang, Jing Wang, Yan Zhao, Qiu Zhong, Gang Li, Zhifeng Fu, Shuguang Lu
Summary: Endolysin LysP108 demonstrates promising antibacterial potential as it can lyse bacterial cell walls, inhibit bacterial biofilms, and work synergistically with vancomycin to reduce abscess size in MRSA-infected mice. The results indicate strong bactericidal effects against MRSA and the ability to significantly reduce subcutaneous abscess size when used in combination with vancomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Infectious Diseases
Elham Zarenezhad, Hussein T. Abdulabbas, Mahrokh Marzi, Esraa Ghazy, Mohammad Ekrahi, Babak Pezeshki, Abdolmajid Ghasemian, Amira A. Moawad
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) has developed extensive antibiotic resistance and contains virulence factors for severe infections. Nickel nanoparticles (NiNPs) have shown potential as a cheap prognostic and therapeutic agent, exerting antibacterial effects through disrupting cell membranes, deforming proteins, and inhibiting DNA replication.
Article
Microbiology
Kuan-Yi Lu, Nikki J. Wagner, Amanda Z. Velez, Agathe Ceppe, Brian P. Conlon, Marianne S. Muhlebach
Summary: MRSA infections are common and chronic in cystic fibrosis patients but are often resistant to antibiotic therapy. This study investigated whether bacterial phenotypes could predict the clinical outcomes of MRSA infections. The results showed no associations between these phenotypes and MRSA clearance, suggesting that additional factors may be relevant for predicting the clearance of MRSA.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Mengli Jin, Shuyue Zhu, Yating Tang, Xiangri Kong, Xingye Wang, Yufen Li, Shuang Jiang, Lin Wei, Chunjie Hu, Bingmei Wang, Wu Song
Summary: Antimicrobial resistance (AMR) is a global health threat, and there is a need for new anti-infective agents. Ayanin, a flavonoid extracted from Callicarpa nudiflora, was found to be an inhibitor of MRSA ClpP, suggesting its potential therapeutic effect against MRSA infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Adeline Espinasse, Manibarsha Goswami, Junshu Yang, Onanong Vorasin, Yinduo Ji, Erin E. Carlson
Summary: The emergence of drug-resistant bacteria has led to the need for novel approaches and targets to combat this challenge. Bacterial two-component systems (TCSs) are important in bacterial adaptive responses and are linked to antibiotic resistance and virulence. A study developed maleimide-based compounds and evaluated them against a model histidine kinase, resulting in the identification of a molecule that decreased the lesion size caused by methicillin-resistant S. aureus skin infection by 65% in a murine model.
Article
Infectious Diseases
Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Evgenia I. Deryusheva, Ekaterina L. Nemashkalova, Irina O. Chikileva, Tatiana N. Abashina, Alexander N. Panin, Vyacheslav G. Melnikov, Nataliya E. Suzina, Ilia N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev
Summary: LF3872 strain from a lactating woman produces a thermolabile class III bacteriolysin (BLF3872) that exhibits antimicrobial activity against antibiotic-resistant Staphylococcus aureus strains. The study is important for developing new drugs against antibiotic-resistant S. aureus strains circulating in both human and animal environments.
Article
Chemistry, Medicinal
Jae-Young Jeong, In-Geun Jung, Seung-Hoon Yum, You-Jin Hwang
Summary: The combination of selected medicinal plant extracts showed synergistic inhibitory effects on the growth of methicillin-resistant Staphylococcus aureus (MRSA) strains, reducing individual component doses and minimizing side effects. The combination of Sanguisorba officinalis and Uncaria gambir extracts exhibited the best synergism. The results suggest that using plant extract combinations could be a potential strategy to treat MRSA infections.
Article
Infectious Diseases
Hyunjung Lee, Jaehoan Lee, Juchan Hwang, Sinyoung Park, Namyoul Kim, Kideok Kim, Honggun Lee, David Shum, Soojin Jang
Summary: The study screened 182 FDA-approved drugs and identified three potential antibiotic candidates against Staphylococcus aureus. Among them, eltrombopag showed the highest antibacterial activity, with significant potency against not only a drug-sensitive S. aureus strain but also 55 clinical isolates including 35 methicillin-resistant S. aureus.
Article
Environmental Sciences
Sarah Rhodes, Elizabeth Christenson, Allie Nguyen, Jesper Larsen, Lance B. Price, Jill Stewart
Summary: The study found that industrial hog operations are more likely to carry multidrug-resistant Staphylococcus aureus compared to hogs raised without antibiotics. Conversely, antibiotic-free hogs are more likely to carry human-adapted S. aureus. This highlights the influence of antibiotic use practices on S. aureus populations in U.S. hogs and calls for increased monitoring for antibiotic resistance management.
ENVIRONMENTAL RESEARCH
(2021)
Review
Immunology
Sarah E. Rowe, Jenna E. Beam, Brian P. Conlon
Summary: Antibiotic treatment failure of Staphylococcus aureus infections is common, with various factors limiting antibiotic efficacy in vivo; one major obstacle is the ability of S. aureus to enter a physiological state incompatible with antibiotic killing. To address the problem of recalcitrant S. aureus infection, specific approaches targeting tolerant cells within different niches may be required, including direct targeting of persister cells or improved penetration of antibiotics to particular niches.
INFECTION AND IMMUNITY
(2021)
Article
Materials Science, Multidisciplinary
Jill Ziesmer, Poojabahen Tajpara, Nele-Johanna Hempel, Marcus Ehrstrom, Keira Melican, Liv Eidsmo, Georgios A. Sotiriou
Summary: A microneedle array with a water-insoluble support layer has been developed for controlled delivery of vancomycin into the skin, showing promising results in reducing local drug concentration issues and systemic exposure risks.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
