Article
Endocrinology & Metabolism
Rui Li, Jun-Xiang Chen, Qi Lu, Ting-Ting Geng, Peng-Fei Xia, Yi Wang, Liang-Kai Chen, Zhi-Lei Shan, An Pan, Gang Liu
Summary: The study aimed to investigate the associations between lipoprotein subclasses categorized by particle sizes and the risk of all-cause and cardiovascular disease (CVD) mortality in individuals with type 2 diabetes. The findings showed that the associations between lipoprotein particles, particularly high-density lipoprotein (HDL) particles, and all-cause and CVD mortality varied significantly by particle sizes among patients with type 2 diabetes, highlighting the importance of particle size as a lipoprotein metric in mortality risk discrimination.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biophysics
Jianfang Cao, Peiying Lv, Yang Shu, Jianhua Wang
Summary: A multiplexed sensor platform combined with an encoder system is introduced for accurate analysis of multiple lipoproteins in complex matrix, achieving highly facile and precise identification for lipoprotein subclasses. The system can accurately identify LDL at 0.05-37.5 μg/mL and 11 typical proteins including three lipoprotein subclasses in human serum, as well as different molar ratios of lipoprotein subclasses from real clinical serum samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Livia Noemi Kolb, Alaa Othman, Lucia Rohrer, Jan Kruetzfeldt, Arnold von Eckardstein
Summary: Biomarkers are important for early detection and stratification of diabetes and its complications. In this study, we used NMR spectrometry to analyze metabolic parameters in plasma samples of healthy volunteers and diabetic patients. Our results showed independent associations between diabetes and branched-chain amino acids, lactate, linoleic acid, and HDL diameter. Additionally, we found imbalances in the concentrations of free cholesterol in different lipoprotein subclasses in diabetic subjects compared to non-diabetic controls, which may reflect disturbances in cholesterol transfer processes.
Article
Peripheral Vascular Disease
Tingting Li, Yingyi Zhang, Jinghan Xu, Le Wang, Fomin Zhang, Hongliang Cong
Summary: Patients with normal blood cholesterol profiles may still be at risk of coronary artery disease (CAD), but lipoprotein subfractions can help identify these risks. LDL-P6 and Lp(a) are independent risk factors for CAD and can be used to predict the presence and severity of the disease.
Article
Biochemistry & Molecular Biology
Martin Rief, Reinhard Raggam, Peter Rief, Philipp Metnitz, Tatjana Stojakovic, Markus Reinthaler, Marianne Brodmann, Winfried Maerz, Hubert Scharnagl, Guenther Silbernagel, And Gunther Silbernagel
Summary: This study compared the lipofit and lipoprofile NMR methods and compared their measurements with clinical chemistry methods. The results showed that both NMR methods can reliably measure standard lipids, but harmonization efforts are needed to improve comparability of particle concentration data.
Article
Biochemistry & Molecular Biology
Lilla Juhasz, Hajnalka Lorincz, Anita Szentpeteri, Nora Toth, Eva Varga, Gyorgy Paragh, Mariann Harangi
Summary: This study found that serum SDF-1 levels were significantly lower in HeFH patients compared to healthy controls, and showed correlations with lipid fractions and subfractions, highlighting potential common pathways of SDF-1 and lipoprotein metabolism and supporting its role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Trine L. Wilkens, Kaare Tranaes, Jane N. Eriksen, Lars O. Dragsted
Summary: Moderate alcohol consumption is associated with changes in lipoprotein subfractions that could influence cardiovascular health positively, but the heterogeneous laboratory methods and risk of bias in studies limit comparability between studies.
Review
Cardiac & Cardiovascular Systems
Abdolreza Chary, Maryam Tohidi, Mehdi Hedayati
Summary: This study evaluated the association between LDL subfractions and cardiovascular disorders through a systematic review. The results showed that a higher LDL particle number was consistently associated with increased risk for cardiovascular disease, and the presence of small dense LDL was also associated with an increased risk of CVDs. Further studies are needed to identify the mechanisms involved.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Qiao Jin, Eric S. H. Lau, Andrea O. O. Luk, Claudia H. T. Tam, Risa Ozaki, Cadmon K. P. Lim, Hongjiang Wu, Elaine Y. K. Chow, Alice P. S. Kong, Heung Man Lee, Baoqi Fan, Alex C. W. Ng, Guozhi Jiang, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y. Y. Leung, Man-wo Tsang, Elaine Y. N. Cheung, Grace Kam, Ip Tim Lau, June K. K. Li, Vincent T. T. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Weichuan Yu, Stephen K. W. Tsui, Yu Huang, Hui-yao Lan, Cheuk Chun Szeto, Wing Yee So, Alicia J. J. Jenkins, Juliana C. N. Chan, Ronald C. W. Ma
Summary: This study assessed the associations of different-sized HDL subclasses with cardiovascular disease and mortality in patients with diabetes. The results showed that small HDL particles were inversely associated with incident cardiovascular disease and all-cause mortality, while very large HDL particles were positively associated with all-cause mortality. Small HDL particles improved the prediction of adverse outcomes in patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei Zhang, Jinglu Jin, Huiwen Zhang, Yaxin Zhu, Qian Dong, Jing Sun, Yuanlin Guo, Kefei Dou, Ruixia Xu, JianJun Li
Summary: This study investigated the value of high-density lipoprotein (HDL) subfractions in predicting cardiovascular events (CVEs) in untreated type 2 diabetes mellitus (T2DM) patients with stable coronary artery disease (SCAD). The concentration of the mixed HDL subfraction was found to be related to the incidence of CVEs in T2DM patients with SCAD, and it was positively associated with increased CVEs even after adjustment in three models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Sara Csiha, Balazs Ratku, Sandor Somodi, Ferenc Sztanek, Ildiko Seres, Gyorgy Paragh, Mariann Harangi
Summary: This study investigates the association between betatrophin and lipoprotein subfractions. The results show that betatrophin concentrations are significantly higher in obese patients with type 2 diabetes (T2D) and nondiabetic obese (NDO) subjects compared to healthy controls, particularly in females. The findings highlight the importance of measuring serum betatrophin for cardiovascular risk assessment in obese patients, with consideration of gender differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Saska Djekic, Jelena Vekic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Srdjan Kafedzic, Marija Zdravkovic, Ivan Ilic, Sasa Hinic, Milivoje Cerovic, Milica Stefanovic, Marija Mihajlovic, Aleksandar Neskovic, Natasa Bogavac-Stanojevic
Summary: The aim of this study was to assess the impacts of oxidative stress, inflammation, and the presence of sdLDL on the antioxidative function of HDL subclasses and the distribution of PON1 activity within HDL in patients with STEMI. The results showed significant differences in the proportions of HDL subclasses and the distribution of PON1 in STEMI patients compared to the control group. There were positive associations between sdLDL and PON1 activity within HDL subclasses. The increased oxidative stress and sdLDL in STEMI patients are closely related to the compromised antioxidative function of small HDL3 particles and the altered PON1 distribution within HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Silvia de la Cruz-Ares, Ana Leon-Acuna, Elena M. Yubero-Serrano, Jose D. Torres-Pena, Antonio P. Arenas-de Larriva, Magdalena P. Cardelo, Oriol A. Rangel-Zuniga, Raul M. Luque, Juan F. Alcala-Diaz, Jose M. Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda, Javier Delgado-Lista
Summary: This study investigated the association between lipoprotein subfractions and the severity of coronary heart disease (CHD) using high-throughput nuclear magnetic resonance (NMR) spectroscopy. The results showed that small and medium HDL subclasses concentration, as measured by NMR, were inversely related to angiographic CHD severity. These particles were also found to be independent predictors of multivessel coronary disease (MVD) and improved the prediction of this condition compared to traditional risk factors.
CLINICA CHIMICA ACTA
(2022)
Article
Medical Laboratory Technology
Victoria Higgins, Lawrence A. Leiter, Sarah R. Delaney, Daniel R. Beriault
Summary: The study validated the superiority of the NIH LDL-C equation over the Friedewald equation, particularly in patients with hypertriglyceridemia and/or low LDL-C. The NIH equation showed a stronger correlation with ultracentrifugation LDL-C and improved accuracy after applying restriction criteria, making it a more reliable choice for lipid management in clinical practice.
CLINICAL BIOCHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Shuai Ma, Mingfeng Xia, Xin Gao
Summary: Despite significant advancements in managing atherosclerosis, cardiovascular disease resulting from it remains a major cause of morbidity and mortality. Novel biomarkers such as quantitative nuclear magnetic resonance (qNMR) metabolomics show promise in providing deeper insights into the mechanisms of atherogenic diseases. As more research is conducted, qNMR metabolite biomarkers may become valuable tools in daily clinical practice for preventing, detecting, and treating atherosclerotic diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Bojan Mitrovic, Zoran M. Gluvic, Milan Obradovic, Maja Radunovic, Manfredi Rizzo, Maciej Banach, Esma R. Isenovic
Summary: Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), and type 2 diabetes (T2DM) are highly prevalent metabolic disorders with significant impacts on global public health. MetS is a complex condition characterized by glucose intolerance, insulin resistance, dyslipidemia, inflammation, and hypertension. NAFLD, recognized as a hepatic manifestation of MetS, is often associated with T2DM. This review examines the underlying connections between these diseases and the risks associated with their co-occurrence.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sarina Ataei, Amir Abbas Momtazi-Borojeni, Shiva Ganjali, Maciej Banach, Amirhossein Sahebkar
Summary: This study evaluated the immunogenic potential of a carrier-free peptide-based anti-PCSK9 vaccine in albino mice. The results showed that the vaccine induced a significant production of IgG antibodies and inhibited PCSK9 concentrations and its interaction with LDLR in the blood plasma.
CURRENT MEDICINAL CHEMISTRY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maciej Banach, Christopher P. Cannon, Francesco Paneni, Peter E. Penson
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Sajjad Chamani, Omid Kooshkaki, Maryam Moossavi, Mandana Rastegar, Sara Saffar Soflaei, Alice P. McCloskey, Maciej Banach, Amirhossein Sahebkar
Summary: Statins not only lower lipid levels, but also modulate immune cell function and differentiation. Further research is needed to understand the molecular targets of statins in regulating the immune response, given their potential advantages in treating inflammatory and autoimmune disorders.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Adrian V. Hernandez, Vinay Pasupuleti, Nancy Scarpelli, Jack Malespini, Maciej Banach, Agata M. Bielecka-Dabrowa
Summary: This study assessed the benefits and harms of Sacubitril/valsartan (S/V) compared to ACEI or ARB in heart failure patients. The results showed that S/V reduced HF hospitalizations by 20%, CV mortality by 14%, and all-cause mortality by 11% compared to ACEI or ARB. However, S/V had negative effects on renal function and increased hypotension events.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Amir Vahedian-Azimi, Farshad Heidari Beni, Zlatko Fras, Maciej Banach, Seyede Momeneh Mohammadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: AKI is a common and severe complication in critically ill patients, with high mortality rates. Statin therapy may have beneficial effects on the disease by reducing mortality rates and overall hospital length of stay. However, the impact of statin treatment on the development of AKI and ICU stay is inconclusive.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Letter
Medicine, General & Internal
Kamal Awad, Carl J. Lavie, Maciej Banach
MAYO CLINIC PROCEEDINGS
(2023)
Article
Clinical Neurology
George Howard, Maciej Banach, Brett Kissela, Mary Cushman, Paul Muntner, Suzanne E. Judd, Virginia J. Howard
Summary: This study assessed the association between stroke risk factors and incident stroke, and evaluated whether the magnitude of this association is uniform across different age groups. The results showed that the associations of hypertension and diabetes with stroke significantly decreased in older age groups, while the associations of smoking, atrial fibrillation, and left ventricular hypertrophy with stroke did not vary with age.
Article
Nutrition & Dietetics
Simona Terzo, Antonella Amato, Antonio Magan-Fernandez, Giuseppa Castellino, Pasquale Calvi, Roberta Chianetta, Rosaria V. Giglio, Angelo M. Patti, Dragana Nikolic, Alberto Firenze, Flavia Mule, Marcello Ciaccio, Manfredi Rizzo
Summary: Pre-obesity is a condition that increases the risk of obesity, cardiovascular diseases, and diabetes. A study found that Altilix(R), a nutraceutical containing chlorogenic acid and luteolin extracts, can improve hepatic and cardio-metabolic parameters. In a post-hoc analysis, Altilix(R) was shown to effectively improve anthropometry, glucose metabolism, lipid profile, hepatic functionality, carotid-media thickness, and endothelial function in pre-obesity subjects.
Article
Green & Sustainable Science & Technology
Julia Nowak, Roman Jaskulski, Wojciech Kubissa, Bartlomiej Matusiak, Maciej Banach
Summary: This study investigated the strength and thermal properties of concrete with crumb rubber from used tyres replacing part of the aggregate. The results showed a decrease in compressive strength and improved insulation properties with an increase in rubber content. A thermomechanical index was introduced to evaluate the functionality of the concrete, and only three out of twelve series failed to meet the performance requirements.
Letter
Medicine, General & Internal
Kamal Awad, Maged Mohammed, Seth S. Martin, Maciej Banach
Summary: This study found that electronic nicotine delivery systems (ENDS) use was significantly associated with an increased risk of stroke compared to non-users, while there was no association between former ENDS use and the risk of stroke.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Oncology
Davide Gnocchi, Dragana Nikolic, Rosa Rita Paparella, Carlo Sabba, Antonio Mazzocca
Summary: Cancer is a major health concern, and current treatments are not very effective. The study of tumor cell metabolism and adaptation mechanisms can provide insights for improving pharmacological options. The recent Systemic-Evolutionary Theory of the Origin of Cancer (SETOC) suggests that cancer cells adapt to extreme microenvironmental conditions and may revert to primitive characteristics.
Review
Public, Environmental & Occupational Health
Andy Wai Kan Yeung, Ali Torkamani, Atul J. Butte, Benjamin S. Glicksberg, Bjorn Schuller, Blanca Rodriguez, Daniel S. W. Ting, David Bates, Eva Schaden, Hanchuan Peng, Harald Willschke, Jeroen van der Laak, Josip Car, Kazem Rahimi, Leo Anthony Celi, Maciej Banach, Maria Kletecka-Pulker, Oliver Kimberger, Roland Eils, Sheikh Mohammed Shariful Islam, Stephen T. Wong, Tien Yin Wong, Wei Gao, Soren Brunak, Atanas G. Atanasov
Summary: This narrative review discusses the current use and future strategies of digital health technologies in modern healthcare applications. It outlines the strengths, limitations, and applications of the scientific field and predicts the future impact of emerging key technologies. Additionally, recommendations are provided to accelerate and benefit the research, translation, and utilization of digital health technologies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
Alexandr Ceasovschih, Victorita Sorodoc, Annabelle Shor, Raluca Ecaterina Haliga, Lynn Roth, Catalina Lionte, Viviana Onofrei Aursulesei, Oana Sirbu, Nicolae Culis, Albina Shapieva, Mohammed A. R. Tahir Khokhar, Cristian Statescu, Radu A. Sascau, Adorata Elena Coman, Alexandra Stoica, Elena-Daniela Grigorescu, Maciej Banach, Costas Thomopoulos, Laurentiu Sorodoc
Summary: The COVID-19 pandemic, which started in Wuhan, China, in early 2020, has caused a global health crisis. The disease mainly affects the respiratory system but can also have an impact on other systems, including the cardiovascular system. The relationship between atherosclerosis and COVID-19 is bidirectional, with both conditions exacerbating each other. The pandemic has also led to reduced access to healthcare amenities, an increase in sedentary lifestyles and unhealthy eating habits, resulting in a high prevalence of overweight and obese individuals. The long-term healthcare challenges posed by COVID-19 can be mitigated by the lessons learned and the advancements made in patient care during this crisis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Medicine, General & Internal
Ioannis Ilias, Charalampos Milionis, Lina Zabuliene, Manfredi Rizzo
Summary: Thyroid function and glucose status are closely linked, and studies have shown the relationship between iodine and glucose metabolism, diabetes, and prediabetic conditions. The potential beneficial effect of iodine on glucose metabolism may be due to its antioxidant properties. However, further research is needed to fully understand the mechanism behind this relationship.
MEDICINA-LITHUANIA
(2023)