期刊
CURRENT MEDICINAL CHEMISTRY
卷 20, 期 30, 页码 3677-3692出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867311320999165
关键词
Antioxidants; cancer biology; cancer progression; cancer therapy; carcinogenesis; reactive oxygen species
资金
- Deutsche Forschungsgemeinschaft (DFG) [BA 3826/5-1]
Reactive oxygen species (ROS) are a group of highly reactive chemicals under tight control of intracellular antioxidants. The balance in oxidation-antioxidation is essential for maintaining normal cell functions, and any imbalance could lead to a wide range of diseases including cancer. The intracellular level of ROS is generally elevated in cancer cells, revealing a critical role of ROS in the process of carcinogenesis and cancer progression. Conversely, there is also evidence showing that ROS can act as cancer suppressors. This may be due to the varying antioxidant capacities of different cancers. These findings indicate a complex redox state in cancer cells. In this review we summarize the main features of ROS and their functions with respect to cancer initiation, hallmarks of cancer, and signaling in cancer cells. ROS-elevating and ROS-depleting anticancer strategies and their mechanisms are thoroughly discussed. We argue that the rationale for therapy choice depends on a complete understanding of cancer cell redox state, namely, the redox signaling signature of cancer.
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