期刊
CURRENT MEDICINAL CHEMISTRY
卷 20, 期 20, 页码 2572-2582出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/09298673113209990120
关键词
Bioavilability; formulations; inclusion complexes; liposomes; micelles; nanoparticles; prodrug; quercetin; solubility
资金
- Natural Science Foundation of Shandong Province, China [ZR2011 HM026]
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
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