Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2015) Peter Vaupel et al.   ANTIOXIDANTS & REDOX SIGNALING

Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies

(2013) Leon Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ

(2013) Kyeung Min Joo et al.   Cell Reports

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications

(2012) Liuqi Yang et al.   EXPERIMENTAL CELL RESEARCH

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

(2012) Chii-Wen Chou et al.   NEURO-ONCOLOGY

In vivo models of primary brain tumors: pitfalls and perspectives

(2012) P. C. Huszthy et al.   NEURO-ONCOLOGY

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Oncolytic Herpes Simplex Virus Counteracts the Hypoxia-Induced Modulation of Glioblastoma Stem-Like Cells

(2012) Donatella Sgubin et al.   Stem Cells Translational Medicine

Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 – 2010)

(2011) Hyun Seung Ban et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells

(2011) H. Wakimoto et al.   NEURO-ONCOLOGY

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology

(2010) K. R. Porter et al.   NEURO-ONCOLOGY

Human Glioblastoma-Derived Cancer Stem Cells: Establishment of Invasive Glioma Models and Treatment with Oncolytic Herpes Simplex Virus Vectors

(2009) H. Wakimoto et al.   CANCER RESEARCH

High-grade glioma mouse models and their applicability for preclinical testing

(2009) Nienke A. de Vries et al.   CANCER TREATMENT REVIEWS

Hypoxia Helps Glioma to Fight Therapy

(2009) Verena Amberger-Murphy   CURRENT CANCER DRUG TARGETS

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway

(2008) Elizabeth W. Newcomb et al.   ANTI-CANCER DRUGS

Tumor Angiogenic and Hypoxic Profiles Predict Radiographic Response and Survival in Malignant Astrocytoma Patients Treated With Bevacizumab and Irinotecan

(2008) Sith Sathornsumetee et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of Hypoxia-inducible Factor-1α Silencing on the Sensitivity of Human Brain Glioma Cells to Doxorubicin and Etoposide

(2008) Lei Chen et al.   NEUROCHEMICAL RESEARCH

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis

(2008) P. Vaupel   ONCOLOGIST

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA