期刊
CURRENT MEDICINAL CHEMISTRY
卷 18, 期 14, 页码 2174-2185出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711795656234
关键词
Brugia malayi; filariasis control programs; loiasis; lymphatic filariasis; onchocerciasis; Onchocerca volvulus; target based antifilarial agents; Wuchereria bancrofti
资金
- University Grants Commission, New Delhi, India [37-596/2009 SR]
Lymphatic filariasis, onchocerciasis and loiasis caused by human filarial nematodes are diseases of tropical and subtropical countries causing considerable morbidity. The available control strategies have significant limitations such that current drugs are ineffective against macrofilariae (adult worms), require repeated and prolonged treatment over years and are threatened by emergence of drug resistance. Due to this concern, these diseases are the focus of renewed scientific interest and much has been done in filariasis research in the past decade. This review summarizes the current status of filariasis, different control strategies, recent advances in antifilarial chemotherapy including currently used drugs, their pros and cons, their mechanism of action, and recently discovered targets and prototypes.
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