Review
Genetics & Heredity
Si Xu, Haihui Liu, Chen Wang, Yu Deng, Bin Xu, Tianyao Yang, Wei Liu
Summary: The unfolded protein response (UPR) is a cellular stress response mechanism that is induced by the accumulation of unfolded or misfolded proteins. It restores organelle homeostasis and promotes cell survival by increasing the expression of chaperone proteins, regulating protein quality control systems, and enhancing the protein degradation pathway. However, abnormal UPR can lead to cell death and is associated with neurodegenerative diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Mahdieh Azizi, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Alireza Andalib, Marzieh Rezaei
Summary: Immunogenic cell death (ICD) is a cellular death induced by specific anticancer therapies, which enhances anti-tumor immune responses. Endoplasmic reticulum stress (ERS) has been found to be closely linked to ICD. Recent evidence suggests that miRNAs associated with unfolded protein response (UPR) play a role in ERS-induced ICD. This study conducted a literature review on the role of these miRNAs and associated molecular pathways in regulating ICD.
Article
Plant Sciences
Maria De Benedictis, Antonia Gallo, Danilo Migoni, Paride Papadia, Pietro Roversi, Angelo Santino
Summary: We studied the response of Arabidopsis thaliana to chronic and temporary Cd2+ stress, finding that Cd2+ induces ER stress and unfolded protein response (UPR) through the bZIP60 arm. The UPR activation is concentration- or time-dependent and leads to the activation of ER stress marker genes. Severe Cd2+ stress triggers programmed cell death (PCD) through NAC089 activation. The Atbzip28/bzip60 double mutant shows reduced UPR and PCD, as well as enhanced Cd2+ tolerance, possibly due to increased brassinosteroids signaling.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maria Bozko, Przemyslaw Bozko
Summary: This article discusses the exciting observation of cell-to-cell transmission of the unfolded protein response (UPR) in cell biology, along with the effectiveness of treatment with specific compounds to induce UPR response and the potential sources of experimental artifacts.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Mingming Shi, Yan Chai, Jianning Zhang, Xin Chen
Summary: Neuronal death and inflammatory response are common pathological features in neurological diseases. The accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, which has been implicated in almost all neurological diseases. The unfolded protein response is activated to restore proteostasis, but if the damage is irreversible, it triggers intracellular cascades of death and inflammation. Targeting ER stress has emerged as a potential therapeutic approach for neurological diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Vibhu Prasad, Urs F. Greber
Summary: Viruses utilize the endoplasmic reticulum unfolded protein response (UPRER) to control cell stress and metabolic pathways, enhancing infection and progeny formation. They trigger cell and organismic stress while maintaining homeostasis. The signaling pathways of UPRER play a crucial role in viral infection and cell survival.
FEMS MICROBIOLOGY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Vibhu Prasad, Urs F. Greber
Summary: Viruses induce cell stress and disrupt homeostasis, but also activate immune responses to limit infection and restore equilibrium through evolutionary conserved stress responses like the UPRER. The UPRER plays a crucial role in controlling cell stress and metabolic pathways during viral infections, enhancing infection or leading to cell death.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara
Summary: Exposure to methylmercury can induce oxidative and endoplasmic reticulum stress, leading to neuronal cell death. This study investigates the time course signaling alterations of the unfolded protein response (UPR) in the most affected brain areas, revealing a potential therapeutic target for treating neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Wolfgang Vivas, Sebastian Weis
Summary: Pathogens and their toxic byproducts can cause tissue damage in infected hosts, triggering stress responses such as the unfolded protein response (UPR) to limit pathogenesis. However, prolonged or excessive activation of UPR may have detrimental effects including cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Yuki Ishiwata-Kimata, Yukio Kimata
Summary: This article reviews the canonical and up-to-date insights regarding yeast UPR, mainly focusing on the functions and regulation of Ire1 and HAC1.
Review
Biochemistry & Molecular Biology
Noel Verjan Garcia, Kyung U. Hong, Nobuyuki Matoba
Summary: The endoplasmic reticulum (ER) plays a vital role in cell homeostasis and disruptions to its functions can lead to diseases. Dysregulated ER stress and UPR are linked to various human diseases, including inflammatory bowel disease (IBD). A recent study has shown that EPICERTIN can induce a protective UPR in colon epithelial cells, promoting mucosal healing in IBD models.
Review
Plant Sciences
Eduardo B. Simoni, Celio C. Oliveira, Otto T. Fraga, Pedro A. B. Reis, Elizabeth P. B. Fontes
Summary: This article summarizes the specific molecular mechanisms that elicit cell death signaling from ER stress in plants and discusses the potential application of modulators of ER stress pathways in stress tolerance engineering.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Mateusz Kowalczyk, Edward Kowalczyk, Pawel Kwiatkowski, Lukasz Lopusiewicz, Monika Talarowska, Monika Sienkiewicz
Summary: Despite numerous scientific studies on depression, there is still no clear understanding of the causes and mechanisms of depression development. Recent research has found a strong relationship between depression and endoplasmic reticulum (ER) stress, with continuous activation of stress response pathways in patients. Therefore, recommended drugs should aim at reducing ER stress while alleviating symptoms of depression.ongoing search for drugs that can effectively reduce ER stress and relieve depression symptoms.
Article
Geriatrics & Gerontology
Diana Hide, Alessandra Warren, Anabel Fernandez-Iglesias, Raquel Maeso-Diaz, Carmen Peralta, David G. Le Couteur, Jaime Bosch, Victoria C. Cogger, Jordi Gracia-Sancho
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Monica B. Jimenez-Castro, Maria Eugenia Cornide-Petronio, Jordi Gracia-Sancho, Arani Casillas-Ramirez, Carmen Peralta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Cell Biology
Monica B. Jimenez-Castro, Maria Eugenia Cornide-Petronio, Jordi Gracia-Sancho, Carmen Peralta
Article
Cell Biology
Raquel Maeso-Diaz, Zoe Boyer-Diaz, Juan Jose Lozano, Marti Ortega-Ribera, Carmen Peralta, Jaime Bosch, Jordi Gracia-Sancho
Review
Cell Biology
Maria Eugenia Cornide-Petronio, Monica B. Jimenez-Castro, Jordi Gracia-Sancho, Carmen Peralta
Article
Urology & Nephrology
Carmen A. Peralta, Martin Frigaard, Leticia Rolon, Karen Seal, Delphine Tuot, Josh Senyak, Lowell Lo, Neil Powe, Rebecca Scherzer, Shirley Chao, Phillip Chiao, Kimberly Lui, Michael G. Shlipak, Anna D. Rubinsky
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Review
Nutrition & Dietetics
Maria Eugenia Cornide-Petronio, Ana Isabel Alvarez-Mercado, Monica B. Jimenez-Castro, Carmen Peralta
Article
Gastroenterology & Hepatology
Jose Gulfo, Floriana Rotondo, Cindy G. Avalos de Leon, Maria Eugenia Cornide-Petronio, Carla Fuster, Jordi Gracia-Sancho, Monica B. Jimenez-Castro, Carmen Peralta
JOURNAL OF HEPATOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Misaq Heydari, Maria Eugenia Cornide-Petronio, Monica B. Jimenez-Castro, Carmen Peralta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Marc Mico-Carnero, Carlos Rojano-Alfonso, Ana Isabel alvarez-Mercado, Jordi Gracia-Sancho, Arani Casillas-Ramirez, Carmen Peralta
Summary: Microbiota in the gut plays a crucial role in the development of liver diseases and post-operative outcomes. Imbalance in the microbiota can lead to liver diseases. Changes in the microbiota after surgery have significant effects on post-operative outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Marc Mico-Carnero, Arani Casillas-Ramirez, Albert Caballeria-Casals, Carlos Rojano-Alfonso, Alfredo Sanchez-Gonzalez, Carmen Peralta
Summary: The study found that lipid treatment is beneficial in protecting against hepatic damage in steatotic liver transplantation, independent of alterations in the recipient intestine.
Review
Cell Biology
Albert Caballeria-Casals, Marc Mico-Carnero, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Arani Casillas-Ramirez, Ana I. Alvarez-Mercado, Jordi Gracia-Sancho, Carmen Peralta
Summary: This study discusses the role of FGF15/19 in liver surgeries, indicating that it can protect the liver from damage and promote regeneration, and has potential beneficial or harmful effects.
Review
Biochemistry & Molecular Biology
Ana Alvarez-Mercado, Albert Caballeria-Casals, Carlos Rojano-Alfonso, Jesus Chavez-Reyes, Marc Mico-Carnero, Alfredo Sanchez-Gonzalez, Arani Casillas-Ramirez, Jordi Gracia-Sancho, Carmen Peralta
Summary: Hepatocellular carcinoma is a major cause of cancer-related mortality worldwide, with chemotherapy drugs used in treatment causing severe side effects, highlighting the need for safer therapies. Liver regeneration post-resection is a precise response dependent on various growth factors, with dysregulation potentially leading to tumor progression. Understanding and targeting growth factor signaling pathways may hold promise in preventing liver tumor development and promoting successful liver regeneration.
Article
Biochemistry & Molecular Biology
Marc Mico-Carnero, Arani Casillas-Ramirez, Alfredo Sanchez-Gonzalez, Carlos Rojano-Alfonso, Carmen Peralta
Summary: This study investigated the role of Neuregulin-1 (NRG1) in liver transplantation from brain death donors (DBD). The results showed that NRG1 and p21-activated kinase 1 (PAK1) levels increased in both steatotic and non-steatotic grafts from DBDs. The protective effects of NRG1 and PAK1 were associated with increased levels of VEGFA and IGF1, respectively. However, exogenous NRG1 was not an appropriate strategy for liver grafts from DBD.
Review
Cell Biology
Marc Mico-Carnero, Mohamed Amine Zaouali, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Hassen Ben Abdennebi, Carmen Peralta
Summary: Ischemia and reperfusion injury (IRI), an inevitable step in organ transplantation, can cause serious organ damage. Most organs used for transplantation today come from extended criteria donors (ECDs), which are more sensitive to IRI. The main objective of organ preservation solutions is to protect against IRI through specific components.
