Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Review
Dentistry, Oral Surgery & Medicine
Manuel Toledano-Osorio, Francisco Javier Manzano-Moreno, Concepcion Ruiz, Manuel Toledano, Raquel Osorio
Summary: GBR is used to handle maxillofacial bone defects, but current membranes do not completely fulfill requirements, driving need for ideal membrane development; New membrane features require specific evaluation techniques, while nanotechnology and osteoimmunomodulation have impacted cells-membranes interaction.
JOURNAL OF DENTISTRY
(2021)
Article
Microbiology
Jiya Singh, Viswanathan Vijayan, Saiema Ahmedi, Pradeep Pant, Nikhat Manzoor, Tej P. Singh, Pradeep Sharma, Sujata Sharma
Summary: The study demonstrates that lactosmart may serve as a promising new potent antimicrobial agent, showing better inhibitory effects against pathogenic microorganisms compared to native LF. The research findings highlight the tighter binding of LPS to lactosmart, indicating its potential as a targeted approach against pro-inflammatory responses caused by LPS exposure in bacterial infections.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Engineering, Biomedical
Hui Zhu, Kai Zheng, Aldo R. Boccaccini
Summary: In summary, mesoporous silica-based materials, especially MBGs, are promising for biomedical applications due to their bioactivity, biocompatibility, tunable composition, and controllable nanoporosity. Research has shown that MBGs can be doped with therapeutic ions and loaded with specific biomolecules to achieve controllable drug release kinetics. Co-delivery of ions and biomolecules using MBGs can offer synergistic effects for improved therapeutic outcomes.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Pawel Kowalczyk, Katarzyna Kaczynska, Patrycja Kleczkowska, Iwona Bukowska-Osko, Karol Kramkowski, Dorota Sulejczak
Summary: Numerous harmful factors throughout a person's life can disrupt the genome and lead to various diseases. Lactoferrin, an endogenous protein, acts as a miracle molecule with beneficial properties that can protect human cells at all stages.
Article
Multidisciplinary Sciences
Guleid M. Awale, Mohammed A. Barajaa, Ho-Man Kan, Amir Seyedsalehi, Ga Hie Nam, Fatemeh S. Hosseini, Chinedu C. Ude, Tannin A. Schmidt, Kevin W. -H. Lo, Cato T. Laurencin
Summary: Bone grafting procedures are common in the US, with a high societal cost. The use of recombinant human bone morphogenetic proteins (rhBMPs) has limitations, leading to the search for small-molecule therapeutics for bone regeneration. This study successfully applied a novel small-molecule treatment approach in a large bone defect model, promoting bone formation with minimal side effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Chemistry, Medicinal
Zhongcan Peng, Jun He, Yungchi Cheng, Jiekun Xu, Weiku Zhang
Summary: Secoiridoids are natural products with a diverse range of biological activities, including neuroprotection, anti-inflammatory effects, antidiabetic properties, hepatoprotection, and analgesic activities. They can also target multiple molecular pathways involved in tumorigenesis, making them potential precursors for anticancer drug development. This review provides an update on the occurrence, structural diversity, bioactivities, and synthesis of naturally occurring secoiridoids from January 2011 to December 2020, aiming to fill the gap in comprehensive review and open new avenues for pharmacological investigation and drug development based on these compounds.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Chemistry, Medicinal
Mengjie Liu, Barbara F. White, Praveen Praveen, Wenyi Li, Feng Lin, Hongkang Wu, Rong Li, Carlie Delaine, Briony E. Forbes, John D. Wade, Mohammed Akhter Hossain
Summary: The study reported an efficient synthesis method for a novel disulfide dimer of human insulin, which has a similar structure to native insulin and comparable affinity to both the insulin receptor and insulin-like growth factor-1 receptor. In insulin tolerance tests, the dimeric insulin showed equipotency to Actrapid and a sustained duration of action surpassing that of Actrapid and Glargine.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Materials Science, Biomaterials
Donagh G. O'Shea, Caroline M. Curtin, Fergal J. O'Brien
Summary: Articular cartilage in the human body plays a vital role in facilitating frictionless movement of synovial joints. However, its avascular and aneural nature limits its ability to self-repair when damaged. Current surgical treatment options lead to the formation of non-durable tissue, necessitating the need for a new solution. Recent advances in tissue engineering have aimed to recreate the microenvironment of native articular cartilage using biomaterial scaffolds, but the complexity of native tissue has proven to be a challenge. The advent of 3D printing has provided a potential solution by allowing the fabrication of biomimetic scaffolds that mimic the architecture and composition of articular cartilage.
BIOMATERIALS SCIENCE
(2022)
Review
Chemistry, Medicinal
Junmin Zhang, Susan L. Morris-Natschke, Di Ma, Xiao-Fei Shang, Chen-Jie Yang, Ying-Qian Liu, Kuo-Hsiung Lee
Summary: Indolizidine alkaloids are chemical constituents isolated from various plants and animals, with important biological activities. Studying the biological activity and pharmacological effects of these alkaloids can lead to the discovery of new drugs.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Plant Sciences
Goncalo Infante Caldeira, Luis Pleno Gouveia, Rita Serrano, Olga Duarte Silva
Summary: Hypericum genus plants are widely distributed and have been used in traditional medicine for various purposes. These plants produce secondary metabolites with potential clinical biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, among others. However, there is a lack of comprehensive research on the relationship between these natural products and their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities.
Article
Nanoscience & Nanotechnology
Panpan Pan, Yusheng Geng, Le Hu, Qing Liu, Man Liu, Meiqi Cheng, Li Chen, Jingdi Chen
Summary: This study utilizes 3D printing technology to incorporate the abundant calcium sources and bioactive substances in abalone shell into bone regeneration implants, enhancing their osteoinductive and remineralization capacity. The addition of abalone shell significantly improves the thermodynamic stability and mechanical properties of the scaffolds, promoting mineralization. In vitro and in vivo experiments demonstrate good biocompatibility of the hybrid scaffolds and their ability to promote osteoblast proliferation and osteogenesis-related gene expression.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Anthi Petrou, Maria Fesatidou, Athina Geronikaki
Summary: Thiazole is a valuable pharmacophore nucleus with a wide range of biological activities, including antioxidant, analgesic, antimicrobial, antihypertensive, anti-inflammatory, and antipsychotic properties. Recent literature review identified and critically analyzed nearly 124 research articles on the synthesis and biological activities of thiazoles derivatives in the past 5 years.
Article
Dentistry, Oral Surgery & Medicine
S. Kranz, M. Heyder, U. Rabe, P. Liu, A. Mrozinska, A. Guellmar, A. Berg, D. Steen, J. Tuckermann, David C. Watts, Bernd Sigusch, M. Reise
Summary: This study aimed to investigate the osseointegration and bone formation of two different polymeric biomaterials in an ovine model. The results showed that both biomaterials exhibited good osseointegration and bone formation characteristics, making them suitable for further examination in periodontal regeneration studies.
Article
Multidisciplinary Sciences
Shih-Ting Wang, Brian Minevich, Jianfang Liu, Honghu Zhang, Dmytro Nykypanchuk, James Byrnes, Wu Liu, Lev Bershadsky, Qun Liu, Tong Wang, Gang Ren, Oleg Gang
Summary: The study demonstrates the creation of bio-active protein-containing ordered nanomaterials with desired 2D and 3D organizations through the encapsulation of proteins in DNA-based voxels and programmable assembly. This platform approach allows for the retention of protein function in the assembled protein arrays.
NATURE COMMUNICATIONS
(2021)
