Review
Pharmacology & Pharmacy
Le Li, Zhijun Zhu
Summary: Liver fibrosis is an abnormal repair reaction and pathological outcome of chronic liver diseases, and recent studies have found that ferroptosis contributes to its development. Therapeutic agents inducing hepatic stellate cell (HSCs) ferroptosis have shown effectiveness in experimental liver fibrosis models. This review focuses on the mechanism of ferroptosis in liver fibrosis and summarizes the pharmacological effectiveness of different therapeutic agents for its treatment. HSCs ferroptosis may be a potential target for novel therapies against liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Miled Bourourou, Elsa Gouix, Nicolas Melis, Jonas Friard, Catherine Heurteaux, Michel Tauc, Nicolas Blondeau
Summary: Targeting the polyamine-eIF5A-hypusine axis represents a new therapeutic opportunity for stroke and ischemic diseases, with GC7 showing potential in protecting neurons and improving post-stroke motor and cognitive deficits.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Eugenia Trushina, Sergey Trushin, Md Fayad Hasan
Summary: Alzheimer's disease, the most common form of dementia in the elderly, has no cure. Emerging data suggest that mitochondria can initiate an integrated stress response that is beneficial for healthy aging and neuroprotection. Partial inhibition of mitochondrial complex I has been explored as a treatment strategy for various diseases, including Alzheimer's disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Geir Bjorklund, Lili Zou, Jun Wang, Christos T. Chasapis, Massimiliano Peana
Summary: Thioredoxin reductases (TrxRs) are enzymes that reduce thioredoxin, playing a crucial role in the antioxidant system within cells. Inhibition of TrxR is a key clinical goal to address redox balance disturbances. Current research focuses on the importance of TrxRs in cellular functions and the mechanisms of inhibition by metal ions or chemicals.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Yumin Wang, Shuang Wu, Qiang Li, Huiyan Sun, Hongquan Wang
Summary: Emerging evidence suggests that ferroptosis, a unique regulated cell death modality, plays a vital role in the pathophysiological process of neurodegenerative diseases and strokes. Pharmacological inhibition of ferroptosis is identified as a potential therapeutic target for these diseases, and this review summarizes the core mechanisms and roles of ferroptosis in neurodegenerative diseases and strokes. The review also highlights the potential effectiveness of pharmacological inhibition of ferroptosis in treating these diseases and suggests it as a promising avenue for future therapeutic strategies.
Review
Pharmacology & Pharmacy
Morgane Modoux, Nathalie Rolhion, Sridhar Mani, Harry Sokol
Summary: L-Tryptophan is an essential amino acid that undergoes complex metabolism to produce bioactive molecules. Disruptions in its metabolism are associated with various disorders, making it a potential therapeutic target for drug development.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Syedia R. Rahman, James A. Roper, Jane Grove, Guruprasad P. Aithal, K. Tao Pun, Andrew J. Bennett
Summary: As the prevalence of chronic liver diseases continues to rise, there is an urgent need for treatment to prevent cirrhosis-related morbidity and mortality. Integrins, specifically alpha v integrins, are promising targets for therapeutic intervention in the development of liver fibrosis. This review summarizes the current knowledge of alpha v integrins and their respective beta subunits in different organs, with a focus on liver fibrosis, and provides emerging preclinical and clinical data on alpha v integrin inhibitors.
LIVER INTERNATIONAL
(2022)
Review
Immunology
Jiarong Gu, Hao Xu, Yandong Chen, Na Li, Xin Hou
Summary: This article reviews the biosynthesis and functions of miR-223 in innate immunity, highlighting its key role in inflammatory diseases and cancers. Furthermore, it discusses the potential role of miR-223 in liver physiopathology and therapeutic prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elvira Alfaro-Arnedo, Iciar P. Lopez, Sergio Pineiro-Hermida, Alvaro C. Ucero, Francisco J. Gonzalez-Barcala, Francisco J. Salgado, Jose G. Pichel
Summary: The study showed that IGF1R plays a crucial role in asthma, and therapeutic targeting of IGF1R can improve allergic airway inflammation in mice, reducing airway hyperresponsiveness and inflammation.
Review
Biochemistry & Molecular Biology
Mikhail V. Voronin, Elena V. Abramova, Ekaterina R. Verbovaya, Yulia V. Vakhitova, Sergei B. Seredenin
Summary: Modern pharmacotherapy of neurodegenerative diseases is primarily symptomatic and ineffective in halting disease progression. Protein misfolding is regarded as a crucial pathogenic factor in these diseases. Chaperones and endoplasmic reticulum stress mechanisms show promise in regulating these processes. This review provides an analysis of the role of BiP and Sigma1R chaperones in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, and highlights the neuroprotective effect of Sigma1R ligand activation. The interaction between Sigma1R and BiP-associated signaling is also discussed, emphasizing the need for further study in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki
Summary: It was recognized more than 50 years ago that iron deposition in the liver plays a crucial role in liver disease. Recent studies on the regulation of ferroptosis and ferritinophagy prompted investigations on the association of iron and the liver. This review discusses iron absorption and handling by the liver, the role of liver macrophages, and the significance of iron regulators in iron homeostasis. It also analyzes the involvement of iron and ferroptosis in various liver diseases and presents experimental and clinical results on interventions to reduce iron deposition.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pharmacology & Pharmacy
Judit Prat-Duran, Estefano Pinilla, Rikke Norregaard, Ulf Simonsen, Niels Henrik Buus
Summary: Chronic kidney disease is a global health problem affecting 10-15% of the population. Transglutaminase 2 (TG2), a multifunctional enzyme, plays a crucial role in renal fibrosis and pharmacological inhibition of TG2 shows antifibrotic effects in CKD. Further research is needed to translate TG2 inhibition into effective treatments for patients with CKD.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Yuzhen Lu, Junjie Hu, Liang Chen, Shan Li, Ming Yuan, Xianxiang Tian, Peng Cao, Zhenpeng Qiu
Summary: Ferroptosis is a nonapoptotic cell death characterized by excessive accumulation of lipid peroxides and disturbances in cellular iron metabolism, which plays a role in the pathogenesis of liver diseases. The liver, as a major metabolic hub, is involved in the synthesis and transport of plasma proteins and fatty acids, as well as iron storage. Pharmacological induction and inhibition of ferroptosis have potential therapeutic effects in hepatic disorders associated with lipid peroxidation. This review outlines the features, molecular mechanisms, and modulatory networks of ferroptosis in liver diseases, and summarizes the mechanisms by which ferroptosis inducers and inhibitors improve liver diseases. Natual active ingredients show efficacy in regulating ferroptosis in preclinical liver disease models.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Ophthalmology
Jessica M. Skeie, Darryl Y. Nishimura, Cheryl L. Wang, Gregory A. Schmidt, Benjamin T. Aldrich, Mark A. Greiner
Summary: This article delves into the importance of mitochondrial function in aerobic eukaryotic cells, emphasizing the balance of mitochondrial dynamics and the mechanism of mitophagy. It also reviews the presence of impaired mitophagy in ocular diseases, offering insight into a potential targeted mechanism for treating ocular diseases characterized by oxidative stress and mitochondrial dysfunction.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)