Review
Chemistry, Multidisciplinary
Weihua Chen, Zhen Sun, Lehui Lu
Summary: This review highlights the main drawbacks of current anticancer drugs and the urgency to improve targeting efficacy. It summarizes current targeting strategies and offers guidelines for structure optimization to obtain effective targeting drugs. Additionally, it presents viewpoints on crucial problems and potential challenges in future research on targeted cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Shibo Lin, Chun Liu, Xiaotian Zhao, Xiao Han, Xuanhao Li, Yongqin Ye, Zheyu Li
Summary: Pyridinones have emerged as an important component in medicinal chemistry, serving as both hydrogen bond donors and acceptors. Their physicochemical properties can be controlled through synthetic routes, allowing for diverse applications in drug design, biomolecular mimetics, and kinase hinge-binding motifs. Furthermore, pyridinone derivatives exhibit various biological activities, making them valuable in drug discovery.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Muhammad Faisal, Aamer Saeed
Summary: Quinazolines are significant heterocyclic compounds with diverse biological properties, and there is a growing importance in designing novel quinazolines, exploring synthesis routes, and seeking potential applications in recent decades. This review article describes eco-friendly synthetic strategies for quinazolines and aims to provide an effective methodology for readers to better understand the formation of quinazoline skeletons. Future research on synthesizing quinazolines and developing more promising synthetic approaches is anticipated to benefit from this review.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Organic
Oleksandr O. Grygorenko, Dmitriy M. Volochnyuk, Bohdan V. Vashchenko
Summary: Current medicinal chemistry heavily relies on the quality of building blocks, with an emergence of many novel (or well-overlooked) chemotypes for drug discovery. This includes adapting new synthetic methodologies, designing new bioisosteres, and paying attention to underrated structural motifs.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Dang Ding, Shujing Xu, Edeildo Ferreira da Silva-Junior, Xinyong Liu, Peng Zhan
Summary: The (re)emergence of multidrug-resistant viruses and the emergence of new viruses have led to an urgent need for new antiviral agents. Peptidomimetics, as therapeutic drugs, offer advantages such as enhanced binding affinity, improved metabolic stability, and better bioavailability. Novel antivirals are being developed through strategies that involve modifying peptides into peptidomimetic derivatives. This review outlines various structural modification design strategies, including terminal structure modifications, pseudopeptides, amino acid modifications, inverse peptides, cyclization, and molecular hybridization, and presents successful examples of peptidomimetic designs.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Medicinal
Rakesh Pahwa, Jatin Chhabra, Raj Kumar, Rakesh Narang
Summary: This paper discusses key approaches to address resistance associated with melphalan, as well as chemical and formulation developments to enhance its characteristics and targeted profile. The rationale of the article also summarizes recent analytical methods, structure-activity relationship, pharmacokinetics, interactions, potential adverse effects, and medicinal updates of melphalan, including synthetic developments, derivatives, conjugates, and prodrugs, along with encouraging insights and research findings.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Green & Sustainable Science & Technology
Tong Li, Sichen Gu, Wei Lv, Feiyu Kang
Summary: This review summarizes the methods for addressing the issues of the unstable solid-electrolyte interphase, rapid dendrite growth, and gas evolution in sodium metal batteries, aiming to achieve a stable interface and prolonged cycling lifespan.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Review
Chemistry, Medicinal
Kadja Luana Chagas Monteiro, Osmar Nascimento Silva, Igor Jose dos Santos Nascimento, Francisco Jaime Bezerra Mendonca Junior, Pedro Gregorio Vieira Aquino, Edeildo Ferreira da Silva-Junior, Thiago Mendonca de Aquino
Summary: The discovery of antibiotics revolutionized medicine by providing effective treatments for various bacterial infections. However, the indiscriminate use of antibiotics has led to the emergence of antibiotic-resistant strains. Recent advances in molecular biology and microbiology have opened new possibilities in drug design and development, allowing the generation of new drugs that are not affected by bacterial resistance mechanisms. Additionally, the combination of drugs with adjuvants shows promise in combating bacterial resistance. This manuscript aims to address the mechanisms of bacterial resistance from a medicinal chemistry perspective and discuss potential strategies for developing new antibiotics.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Danyi Qin, Yi Han, Lixiang Wang, Hongbo Yin
Summary: Corneal crosslinking (CXL) is a technique that strengthens corneal collagen fibers to prevent changes in corneal shape, and it has undergone significant improvements over the past few decades. CXL involves various materials, and summarizing these materials provides a comprehensive understanding of the technique. Innovations in the use of existing materials or the development of new materials can further enhance the safety, effectiveness, stability, and applicability of CXL, benefiting patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Elys Juliane Cardoso Lima, Renan Augusto Gomes, Evelin Fornari, Flavio da Silva Emery, Gustavo Henrique Goulart Trossini
Summary: The development of new drugs has become increasingly challenging over the decades, necessitating continuous evolution and multidisciplinary approaches in medicinal chemistry strategies. Structure-based, ligand-based, and fragment-based drug design techniques play crucial roles in the design and optimization of successful New Molecular Entities approved by the FDA.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Reza Ahmadi, Saeed Emami
Summary: Vinyl sulfone is an important organic compound with a unique chemical structure, playing a significant role in drug discovery and development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Usman Ahmed, Ayaz Anwar, Seng-Kai Ong, Areeba Anwar, Naveed Ahmed Khan
Summary: Acanthamoeba is a genus of free-living amoebae that often causes sight-threatening keratitis and fatal encephalitis. Developing effective treatments for Acanthamoeba infections remains challenging, highlighting the need for new approaches to eliminate such rare but serious infections.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Chemistry, Medicinal
Antti Poso
Summary: WRD5 is a promising target for anticancer drug discovery and plays a vital role in epigenetic regulation. PROTACs offer a new option for biological inactivation of WRD5, and new WRD5 targeting PROTACs introduced in a study make it possible to evaluate WRD5 as a drug target.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Shu Song, Ping Gao, Lin Sun, Dongwei Kang, Jacob Kongsted, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu
Summary: Boron-containing drugs have gained increasing interest in clinical settings, due to their unique binding properties influencing biological activity, pharmacokinetics, and resistance. Recent research has focused on categorizing these compounds based on various activities, such as anti-cancer, antibacterial, antiviral, and antiparasitic, while exploring potential future developments in drug discovery.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Chemistry, Medicinal
Natalia Ferreira de Sousa, Luciana Scotti, Gabriela Cristina Soares Rodrigues, Erika Paiva de Moura, Renata Priscila Barros Costa Barros, Zoe L. Sessions, Eugene N. Muratov, Marcus Tullius Scotti
Summary: Medicinal Chemistry plays a vital role in researching new drugs for neglected diseases, with a focus on Chagas disease and leishmaniasis. Organic synthesis and molecular hybrids are common strategies, with an increasing number of computationally developed studies providing speed and cost optimization in the procurement process.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
