Article
Polymer Science
Alba Cano-Vicent, Andrea Martinez-Agut, Alberto Tunon-Molina, Hamid Bakshi, Roser Sabater i Serra, Iman M. Alfagih, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: Alginate crosslinked with calcium cations is a promising hydrogel for biomedical applications due to its non-toxicity, suitable mechanical properties, and insolubility in water. This study explored the biological properties of alginate films crosslinked with Ca2+ and Co2+ ions, including antiviral capacity, antibacterial properties, and anticancer activity. The results showed that the hydrogel exhibited biocompatibility in vivo and in vitro, as well as antibacterial and antiviral activity against methicillin-resistant Staphylococcus aureus and a surrogate of SARSCoV-2. Additionally, the hydrogel showed anticancer properties against melanoma and colon cancer cells.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Paulina Jurek, Hanna Jedrzejewska, Michal F. Rode, Agnieszka Szumna
Summary: This study designed and synthesized core-fluorescent cavitands based on 2-(2'-resorcinol)benzimidazole fluorophores merged with the resorcin[4]arene skeleton. The cavitands exhibit excited state intramolecular proton transfer (ESIPT) and readily undergo deprotonation to form dianionic cavitands that can strongly bind to organic cations.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Mark P. Walsh, Matthew O. Kitching
Summary: The modes of supramolecular recognition of quaternary phosphonium cations mediated by BINOL have been identified and characterized. X-ray crystallography and surface analysis were used to analyze the solid state structures of the ternary complexes, confirming the presence of characteristic intermolecular interactions. These findings provide valuable insights for the future design of agents capable of recognizing and separating phosphonium cations.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Alba Cano-Vicent, Alberto Tunon-Molina, Hamid Bakshi, Iman M. Alfagih, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: In this study, a novel calcium alginate/acetic acid film was developed and evaluated for its biological properties. The film exhibited biocompatibility with human keratinocyte cells and Caenorhabditis elegans, and demonstrated antiviral and anticancer properties. The findings suggest that this film has potential applications in the biomedical and pharmaceutical industries for developing broad-spectrum antiviral and anticancer materials.
Article
Chemistry, Multidisciplinary
Ayesha M. Patel, E. Neil G. Marsh
Summary: The study demonstrates that viperin activates a component of the protein ubiquitination machinery, enhancing TRAF6's ubiquitin transfer activity and increasing important polyubiquitinated forms, suggesting a potential role as an agonist of immune signaling pathways.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Environmental Sciences
Xiaoyu Liu, Fangkun Zhao, Xianghong Wang, Shuiping Chen, Jingyi Qu, Yaxin Sang
Summary: In this study, Bacillus pumilus E-1-1-1 isolated from feces of 38 kinds of animals was found to have the ability to degrade aflatoxin M1 (AFM1). By conducting whole genome sequencing and proteomics, it was confirmed that eight genes in Bacillus pumilus E-1-1-1 were capable of degrading AFM1, with the most degrading proteins being oxidoreductases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Mikhail Kryuchkov, Jozef Adamcik, Vladimir L. Katanaev
Summary: Researchers have expanded the versatility of bionic nanocoatings by using different Retinin-like proteins and metallization methods, and have identified the best protocols for constructing anti-infective metalized bionic nanocoatings.
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Summary: This study identified epigenetic probes that significantly enhance the cytotoxicity of TAK-243 through off-target ABCG2 inhibition. A cell-based assay was developed to quantitatively evaluate ABCG2 inhibition by drug candidates based on the potentiation of TAK-243 cytotoxicity.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Applied
Laura Gallego-Yerga, Cristina de la Torre, Francesco Sansone, Alessandro Casnati, Carmen Ortiz Mellet, Jose M. Garcia Fernandez, Valentin Cena
Summary: Cyclodextrin-calixarene giant amphiphiles are capable of encapsulating and delivering anticancer drugs to tumor cells with high efficiency, significantly enhancing therapeutic efficacy. The redox-responsive disulfide bridge modification in these amphiphiles allows for efficient cargo release in a tumor microenvironment, leading to potent inhibition of cancer cell proliferation.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Summary: This study identifies epigenetic regulators that can significantly enhance the cytotoxicity of the anticancer drug TAK-243. These regulators exert their effects by inhibiting the efflux transporter ABCG2. The study also develops a cell-based assay to quantitatively evaluate the ABCG2-inhibitory activity of drug candidates.
ACS CHEMICAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mehraneh Kermanian, Samad Nadri, Parvin Mohammadi, Siavash Iravani, Nahid Ahmadi, Vajihe Alinezhad, Mohammad-Ali Shokrgozar, Mahdi Haddad, Ebrahim Mostafavi, Aziz Maleki
Summary: Introduces a subset of MOFs called ZIFs, which have unique structural features and applications in biomedicine. Summarizes the synthesis routes and physicochemical properties of ZIFs, as well as their applications as antibacterial agents and drug carriers. Discusses the recent advancements in tissue regeneration, especially bone regeneration and wound healing, using ZIFs. Lastly, discusses the biological safety aspects, toxicity, and future prospects of ZIFs in regenerative medicine.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemical Research Methods
Seong Eun Son, Pramod K. Gupta, Won Hur, Han Been Lee, Yosep Park, Jiyeon Park, Seong Nyeon Kim, Gi Hun Seong
Summary: This study successfully synthesized mesoporous platinum nanoparticles (MPNs) and found that they exhibited excellent catalytic efficiency and peroxidase-like activity. The MPNs also showed high accuracy and sensitivity in the enzyme-linked immunosorbent assay (ELISA) for C-reactive protein detection.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sarah C. Bete, Leander K. May, Philipp Woite, Michael Roemelt, Matthias Otte
Summary: In this study, a cage ligand providing a biomimetic environment was synthesized, in which copper can adopt different coordination modes. The copper(I) state reacts with dioxygen and undergoes CH activation. Additionally, the ligand exhibits catalytic performance similar to the oxidation of ubiquinol mimics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Xiuqi You, Haibo Li, Baozhu Pan, Mingtao You, Weiling Sun
Summary: The joint toxicity of antibiotics and metals towards aquatic organisms is dependent on their interactions, with complexation leading to antagonistic effects and lack of interactions resulting in additive effects. CTC facilitated the intracellular uptake of metals by increasing membrane permeability, while FLO had no significant effects on metal internalization. Proteomic analysis revealed down-regulation of photosynthetic proteins by CTC and FLO and showed that Cu(II) and Cd(II) induced different responses in protein regulation. Co-exposure of antibiotics and metals alleviated or exacerbated dysregulation of biological functions in Synechocystis sp., suggesting their combined toxicity effects.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Chemistry, Medicinal
Vibha Shukla, Ashish Runthala, Vikrant Singh Rajput, Potla Durthi Chandrasai, Anurag Tripathi, Suresh Chandra Phulara
Summary: Recent medicinal research has discovered antiviral and anticancer terpenoids that are usually used in flavoring, fragrances, and pharmaceuticals. Due to the need for natural therapeutics with minimal side effects, the focus has shifted to the biocatalytic production of these molecules from microbial sources. This study explores the use of computational and synthetic biology approaches to improve the production of terpenoid-based therapeutics from the gram-positive bacterium Bacillus subtilis by utilizing the DXP pathway.
MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Organic
Roman Rodik, Sergiy Cherenok, Olga Kalchenko, Oleksandr Yesypenko, Janusz Lipkowski, Vitaly Kalchenko
CURRENT ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Physical
Francisco J. Ostos, Jose A. Lebron, Pilar Lopez-Cornejo, Manuel Lopez-Lopez, Margarita Garcia-Calderon, Clara B. Garcia-Calderon, Ivan Rosado, Vitaly Kalchenko, Roman Rodik, Maria Luisa Moya
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Chemistry, Multidisciplinary
O. A. Yesypenko, Yu. S. Boiko, K. N. Belikov, K. Yu. Bryleva, Z. Yu. Bunina, A. B. Rozhenko, S. V. Shishkina, A. B. Drapailo, R. V. Rodik, L. I. Atamas, A. A. Golub, V. I. Kalchenko
THEORETICAL AND EXPERIMENTAL CHEMISTRY
(2020)
Article
Chemistry, Physical
Tatyana A. Cheipesh, Daria Kharchenko, Yulia Taranets, Roman Rodik, Nikolay O. Mchedlov-Petrossyan, Mykola M. Poberezhnyk, Vitaly Kalchenko
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Chemistry, Multidisciplinary
Lyudmila V. Tsymbal, Roman V. Rodik, Oksana Danylyuk, Kinga Suwinska, Janusz Lipkowski, Vitaly I. Kalchenko, Yaroslaw D. Lampeka
Summary: The synthesis and characterization of two new derivatives, Thicalix and Pycalix, of calix[4]arene were conducted using IR, NMR, MS, and single crystal X-ray diffraction techniques. Thicalix showed hydrolysis of azomethine bonds and oxidation of aminophenolic fragment in the presence of copper(II) and palladium(II) ions, while Pycalix formed a metallocomplex with potassium tetrachloropalladate(II) with a 1:2 calix[4]arene/Pd(II) ratio. The X-ray diffraction analysis revealed the formation of molecular crystals with various supramolecular interactions in all compounds.
SUPRAMOLECULAR CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Jose Antonio Lebron, Manuel Lopez-Lopez, Clara B. Garcia-Calderon, Ivan V. Rosado, Fernando R. Balestra, Pablo Huertas, Roman V. Rodik, Vitaly I. Kalchenko, Eva Bernal, Maria Luisa Moya, Pilar Lopez-Cornejo, Francisco J. Ostos
Summary: The study investigated the formation of calixarene-based liposomes and their characterization using various techniques. The results showed that liposomes formed with the least cytotoxic calixarene were used as nanocarriers for nucleic acids and an antineoplastic drug. The study also found that the encapsulation efficiency of doxorubicin in these liposomes was high and they exhibited a slow controlled release, potentially reducing the side effects of the drug.
Article
Chemistry, Inorganic & Nuclear
Yuriy Boiko, Konstantin Belikov, Ekaterina Bryleva, Zinaida Bunina, Victoria Varchenko, Andriy Drapailo, Roman Rodik, Alexander Golub, Alexander Katz, Vitaly Kalchenko
Summary: Sequential treatment of silica gel with tetrachlorosilane and cone-shaped tetraphosphorylated tetrahydroxy(thia)calixarenes produced porous organo-inorganic sorbents with surface covered by spatially ordered phosphonate, phosphinate, and phosphine oxide groups capable of cooperatively binding metal cations. Sorption of europium(III) was studied using the modified silica gels.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Multidisciplinary Sciences
Martins Rucins, Roman Rodik, Aiva Plotniece, Nadiia Pikun, Mara Plotniece, Arkadij Sobolev, Vitaly Kalchenko, Karlis Pajuste
Summary: This article presents the characterisation of nanoformulations obtained from calix[4]arene/1,4-dihydropyridine (1,4-DHP) compositions in an aqueous medium using dynamic light scattering (DLS) technique. The hydrodynamic diameters, polydispersity index, and stability of the nanoparticles were determined. The provided data are relevant to previously published research articles and can be used for the development of novel synthetic lipid nanoformulations in medicinal chemistry.
Article
Chemistry, Organic
Martins Rucins, Karlis Pajuste, Aiva Plotniece, Nadiia Pikun, Roman Rodik, Sergiy Vyshnevskiy, Arkadij Sobolev
Summary: In this study, a double-charged cationic amphiphilic compound was constructed in four steps, and the obtained compound and its intermediates were fully characterized by various analysis techniques. Additionally, the formation of nanoparticles by one of the compounds in an aqueous solution was investigated.
Article
Chemistry, Physical
Roman V. Rodik, Sergiy O. Cherenok, Viktoriia Y. Postupalenko, Sule Oncul, Vladyslava Brusianska, Petro Borysko, Vitaly I. Kalchenko, Yves Mely, Andrey S. Klymchenko
Summary: This study reports on the self-assembly behavior of anionic amphiphilic calixarenes in aqueous media. The calixarenes with phosphonate groups and alkyl chains can form micelles of about 10 nm diameter and complex cationic peptides into nanoparticles. Cellular studies show that these anionic amphiphilic calixarenes have low cytotoxicity and enable the internalization of fluorescently labeled peptides into live cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
T. A. Cheipesh, N. O. Mchedlov-Petrossyan, L. N. Bogdanova, D. V. Kharchenko, A. D. Roshal, N. A. Vodolazkaya, Yu. V. Taranets, S. V. Shekhovtsov, R. V. Rodik, V. I. Kalchenko
Summary: This paper investigates the properties of water-soluble ionic calixarenes that form aggregate structures in aqueous solutions and their role in governing chemical processes. By comparing the results with different systems, important information about the structure and behavior of these aggregates is obtained.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuriy Boiko, Konstantin Belikov, Ekaterina Bryleva, Zinaida Bunina, Victoria Varchenko, Alexander B. Rozhenko, Andriy Drapailo, Roman Rodik, Alexander Golub, Alexander Katz, Vitaly Kalchenko
Summary: This article describes a one-pot sequential reaction of silica gel with a tetrachlorosilane/triethylamine mixture and then with a conical upper rim tetraphosphorylated tetrahydroxy(thia)calixarenes, resulting in porous organo-inorganic sorbents modified by spatially ordered phosphonate, phosphinate, or phosphine oxide groups capable of cooperative binding of metal cations. The grafting process improves the efficacy of europium(III) sorption by the silica gels. DFT calculations reveal that the calixarene-Eu3+ complexes adopt a flattened cone conformation with coordination of the Eu3+ cation to three of the four P = O oxygen atoms and one of the aromatic systems, while the inclusion of three water molecules completely excludes cation-pi interactions.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Article
Chemistry, Multidisciplinary
D. V. Kharchenko, V. S. Farafonov, T. A. Cheipesh, N. O. Mchedlov-Petrossyan, R. V. Rodik, V. I. Kalchenko
Summary: The catalytic properties of calix[4]arene with choline groups were studied, showing a significant increase in the initial rate of hydrolysis reaction of 4-nitrophenyl acetate and 4-nitrophenyl palmitate in aqueous borate buffer solutions. The acceleration for 4-nitrophenol ester reached 200 times, surpassing the effect of cationic surfactants cetyltrimethylammonium bromide and N-cetylpyridinium chloride by more than an order of magnitude. The structure of calixarene aggregates in solutions and their influence on the rate of hydrolysis reactions have been analyzed.
THEORETICAL AND EXPERIMENTAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Iuliia I. Mazur, Tetyana O. Veklich, Oleksandr A. Shkrabak, Nikolai A. Mohart, Anatoly M. Demchenko, Inna Gerashchenko, Roman Rodik, Vitaly Kalchenko, Sergiy O. Kosterin
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2018)
