Article
Biochemistry & Molecular Biology
Yunfei Feng, Li Jia, Wan Ma, Chenying Tian, Huahua Du
Summary: This study demonstrated that iron chelation therapy with deferoxamine could improve diabetic nephropathy by attenuating renal dysfunction, preserving podocyte integrity, reducing inflammation and fibrosis.
Article
Materials Science, Multidisciplinary
Jian Qian, Nathan P. Wiederhold, Thomas Patterson, Hoja Patterson, Cory J. Berkland
Summary: Developing broad-spectrum antifungal drugs is essential for reducing the global burden of fungal infections. A high-avidity polymeric iron chelator, PLL-DHBA, developed based on conformational stability effect, exhibited broad-spectrum antifungal activity against various fungi and showed even greater potency against certain drug-resistant fungi than traditional antifungal drugs.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Microbiology
Artid Amsri, Somdet Srichairatanakool, Aphiwat Teerawutgulrag, Sirida Youngchim, Monsicha Pongpom
Summary: This study aimed to enhance the siderophore production in Talaromyces marneffei through genetic modification and determine the characteristics of the siderophore for potential medical applications. Deletion of the negative regulator gene sreA resulted in a high production of extracellular siderophores. The produced siderophore, identified as coprogen B, exhibited strong iron-binding activity and showed inhibitory effects on cancer cells and microorganisms, suggesting its potential as an ideal iron chelator or for other medical applications.
Article
Biochemistry & Molecular Biology
Gina Abdelaal, Andrew Carter, William Cheung, Mihalis Panayiotidis, Seth Racey, David Tetard, Stephany Veuger
Summary: Anti-cancer therapy by iron chelation using SK4 can inhibit multiple cellular processes and target iron addiction and LAT1 overexpression. The mode of action of SK4 was characterized using proteomics, metabolomics, lipidomics and seahorse real-time analysis, revealing impaired energy metabolism and a potential role of ceramide induction in the phenotypic outcome. These findings highlight the effectiveness of SK4 as a double pronged approach towards treating cancer.
Article
Pharmacology & Pharmacy
Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Kai Ding, Mengjiao Zhou, Tianqing Liu
Summary: Pancreatic cancer is a highly lethal disease with a poor prognosis and limited treatment options. In this study, calcium carbonate nanoparticles loaded with a nucleotide reductase inhibitor and a commonly used chemotherapy drug were developed to overcome gemcitabine resistance in pancreatic cancer cells. These nano-formulations effectively suppressed cancer cell proliferation, migration, and resistance to gemcitabine, indicating their potential as an effective treatment option for pancreatic cancer patients.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Axel Steinbrueck, Adam C. Sedgwick, Hai-Hao Han, Michael Y. Zhao, Sajal Sen, Dan-Ying Huang, Yi Zang, Jia Li, Xiao-Peng He, Jonathan L. Sessler
Summary: In this study, strategic functionalization of the FDA approved chelator deferasirox was conducted to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 exhibited improved antiproliferative activity compared to the original compound 1, and was shown to preferentially localize within the lysosome through fluorescent cell imaging.
CHEMICAL COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang
Summary: Iron chelators selectively inhibit beta-catenin-activated cells, and stimulation of IRP2 and iron by beta-catenin enhances mitochondrial function. Depletion of IRP2-sequered iron impairs beta-catenin-invigorated mitochondrial function. The mitochondrial inhibitor S-Gboxin selectively reduces beta-catenin-associated cell viability and tumor formation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Michael S. Petronek, Khaliunaa Bayanbold, Koffi Amegble, Ann M. Tomanek-Chalkley, Bryan G. Allen, Douglas R. Spitz, Charvann K. Bailey
Summary: A distinct characteristic of cancer is the increased expression of sirtuin proteins, particularly SIRTs 1 and 2. Sirtinol, a specific inhibitor of SIRT 1 and 2, has shown cytotoxicity against various types of cancer, including non-small cell lung cancer (NSCLC). Recent research has revealed that sirtinol acts as a tridentate iron chelator, depleting the labile iron pools in NSCLC cells. Additionally, sirtinol induces adaptive responses in A549 cells, affecting transferrin receptor stability, ferritin heavy chain translation, and aconitase activity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Toru Narusaka, Toshiaki Ohara, Kazuhiro Noma, Noriyuki Nishiwaki, Yuki Katsura, Takuya Kato, Hiroaki Sato, Yasuko Tomono, Satoru Kikuchi, Hiroshi Tazawa, Yasuhiro Shirakawa, Akihiro Matsukawa, Toshiyoshi Fujiwara
Summary: High Nanog expression is associated with poor prognosis in esophageal cancer. Iron chelators can suppress the expression of stemness markers, offering a potential novel therapeutic strategy for esophageal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Elisa Tomat
Summary: An altered metabolism of iron is strongly associated with cancer progression. Ongoing research is uncovering the complex iron-trafficking program in cancer biology, involving malignant cells, cancer stem cells, immune cells, and other components in the tumor microenvironment. Anticancer drug discovery is focusing on iron-binding strategies in clinical trials and multiple development programs. By targeting this fundamental player in cancer progression, iron-binding drug candidates have the potential to impact a wide range of cancer types and address major clinical challenges such as recurrence and therapy resistance.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xingzhi Jing, Qiang Wang, Ting Du, Weimin Zhang, Xiaoyang Liu, Qiang Liu, Tao Li, Guodong Wang, Feifei Chen, Xingang Cui
Summary: The study demonstrates that calcium chelators can inhibit iron influx into chondrocytes, reduce iron overload-induced ROS production and mitochondrial dysfunction, thereby reversing the damage caused by iron overload to chondrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Stefano Menghini, Ping Shu Ho, Tinotenda Gwisai, Simone Schuerle
Summary: Using a bacterial strain as a living iron chelator to compete for vital nutrients in tumor growth, this study demonstrated the potential of altering iron homeostasis and inhibiting cancer cell viability. The results suggest the bacterial strain could act as a self-replicating iron-chelating agent, reinforcing current bacterial cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Linjie Shao, Taishun Hu, Xingyu Fan, Xiaozan Wu, Fangfang Zhou, Botao Chen, Songwen Tan, Hui Xu, Anqiang Pan, Shuquan Liang, Yongju He
Summary: In this study, an intelligent nanoplatform was developed to induce efficient chemodynamic therapy (CDT) in the tumor microenvironment. The nanoplatform could convert intracellular H2O2 into toxic ·OH, release Ca2+ and Fe3+ for chemotherapy and oncosis therapy, and amplify CDT through the cleavage of peroxy bonds. The nanoplatform exhibited excellent anticancer efficacy through the synergistic effect of multiple therapeutic modalities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Koichi Fujisawa, Taro Takami, Toshihiko Matsumoto, Naoki Yamamoto, Takahiro Yamasaki, Isao Sakaida
Summary: The combination therapy of deferoxamine (DFO) and alpha-cyano-4-hydroxy cinnamate (CHC) was found to be effective in cancer cells, where treatment with DFO resulted in an increase in lactate levels. DFO-resistant cells exhibited metabolic changes and increased lactate production in response to DFO treatment. However, no synergistic effect was observed in human liver cancer cells.
CANCER & METABOLISM
(2022)
Article
Chemistry, Multidisciplinary
Watchareeporn Chariyarangsitham, Saowalak Krungchanuchat, Piyachat Khuemjun, Chalermchai Pilapong
Summary: Research found that TA is easily oxidized and interacts with amino acids in physiological buffered solutions, resulting in modified TA samples retaining iron-chelating properties but diminishing antioxidant capability and anti-cancer activity. Therefore, these structural alterations should be taken into account in biomedical applications.
ARABIAN JOURNAL OF CHEMISTRY
(2021)