期刊
CURRENT MEDICINAL CHEMISTRY
卷 16, 期 3, 页码 327-349出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709787002682
关键词
Podophyllotoxin; antimitotic; topoisomerase II; hemisynthesis; biosynthesis; biological activities; mode of action; structure-activity relationship
资金
- New Century Excellent University Talents [NCET-06-0868]
- State Education Ministry of China
- Chinese Ministry of Education [107105]
- Doctoral Program of Higher Education of China [20070712025]
Podophyllotoxin is an important and much sought after antimitotic natural lead compound, since it paved the way for three hemisynthetic derivatives of podophyllotoxin, e. g., etoposide, teniposide and etopophos, which are widely used as anticancer drugs and show good clinical effects against several types of neoplasms. Although the publication of the recent reviews by Gordaliza in 2004 and You in 2005, which covered the literatures concerning podophyllotoxin until the early part of 2003, there have been significant number of works carried out on podophyllotoxin recently. Therefore, this review presents up-to-date coverage of podophyllotoxin in regard to hemisynthesis, biosynthesis, biological activities, mode of action and structure-activity relationship.
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