Article
Infectious Diseases
Phuong Nguyen Thi Thu, Minh Ngo Thi Huong, Ngan Tran Thi, Hoi Nguyen Thanh, Khue Pham Minh
Summary: The use of combination therapy with fluoroquinolones and beta-lactam antibiotics for COPD exacerbations caused by gram-negative bacteria appears to be effective in improving microbiological outcomes and reducing CRP levels. While clinical success, lung function, and symptoms were similar in both treatment groups, the combination therapy showed superiority in terms of microbiological success. This suggests that combination therapy should be considered for bacterial infections during COPD exacerbations.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu
Summary: This study reveals the response mechanism of P. aeruginosa to murepavadin and provides a promising antibiotic combination for the treatment of P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Xiaoya Wei, Jiacong Gao, Congjuan Xu, Xiaolei Pan, Yongxin Jin, Fang Bai, Zhihui Cheng, Iain L. Lamont, Daniel Pletzer, Weihui Wu
Summary: This study reveals the response mechanism of Pseudomonas aeruginosa to murepavadin and provides a promising antibiotic combination for the treatment of P. aeruginosa infections.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Eric Reid, Ryan W. Walters, Christopher J. Destache
Summary: The meta-analyses demonstrate that FQ monotherapy significantly improves survival in PA bacteremia and shows similar rates of bacteriological eradication in pneumonia and skin and soft tissue infection caused by PA compared to BL monotherapy. Further research is needed to provide meaningful clinical recommendations.
Article
Pharmacology & Pharmacy
Hana Douafer, Veronique Andrieu, Emmanuel Wafo, Michelle Sergent, Jean Michel Brunel
Summary: The global increase of multidrug resistant bacteria and the lack of new classes of antibiotics are challenging clinicians in treating bacterial infections. A new adjuvant has been identified to enhance antibiotic activity against resistant P. aeruginosa strains. An experimental protocol was developed to optimize a dry powder for inhalation delivering antibiotic and adjuvant simultaneously.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Microbiology
Andrea M. Hujer, Steven H. Marshall, Andrew R. Mack, Kristine M. Hujer, Yamuna Devi Bakthavatchalam, Kushal Umarkar, Snehal R. Palwe, Swapna Takalkar, Prashant R. Joshi, Rahul Shrivastava, Hariharan Periasamy, Sachin S. Bhagwat, Mahesh V. Patel, Balaji Veeraraghavan, Robert A. Bonomo
Summary: Compared to other genera of Gram-negative pathogens, Pseudomonas is adept in acquiring complex non-enzymatic and enzymatic resistance mechanisms thus remaining a challenge to even novel antibiotics including recently developed beta-lactam and beta-lactamase inhibitor combinations. This study shows that the novel beta-lactam enhancer approach enables cefepime/zidebactam to overcome both non-enzymatic and enzymatic resistance mechanisms associated with a challenging panel of P. aeruginosa. This study highlights that the beta-lactam enhancer mechanism is a promising alternative to the conventional beta-lactam/beta-lactamase inhibitor approach in combating ever-evolving MDR P. aeruginosa.
Article
Microbiology
Xinrui Zhao, Yongxin Jin, Fang Bai, Zhihui Cheng, Weihui Wu, Xiaolei Pan
Summary: Aztreonam/avibactam is an effective drug against Metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa, a pathogen causing highly lethal infections. This study discovered a novel gene mutation, PM292, that could lead to resistance to aztreonam/avibactam and beta-lactams. Additionally, the study found that overproduction of pyocyanin increased bacterial resistance to beta-lactams.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Tanya Babich, Pontus Naucler, John Karlsson Valik, Christian G. Giske, Natividad Benito, Ruben Cardona, Alba Rivera, Celine Pulcini, Manal Abdel Fattah, Justine Haquin, Alasdair MacGowan, Sally Grier, Julie Gibbs, Bibiana Chazan, Anna Yanovskay, Ronen Ben Ami, Michal Landes, Lior Nesher, Adi Zaidman-Shimshovitz, Kate McCarthy, David L. Paterson, Evelina Tacconelli, Michael Buhl, Susanna Mauer, Jesus Rodriguez-Bano, Isabel Morales, Antonio Oliver, Enrique Ruiz de Gopegui, Angela Cano, Isabel Machuca, Monica Gozalo-Marguello, Luis Martinez Martinez, Eva M. Gonzalez-Barbera, Iris Gomez Alfaro, Miguel Salavert, Bojana Beovic, Andreja Saje, Manica Mueller-Premru, Leonardo Pagani, Virginie Vitrat, Diamantis Kofteridis, Maria Zacharioudaki, Sofia Maraki, Yulia Weissman, Mical Paul, Yaakov Dickstein, Leonard Leibovici, Dafna Yahav
Summary: A multicentre retrospective study found no mortality advantage with combination therapy over monotherapy for Pseudomonas aeruginosa bacteraemia. There were no differences in clinical failure, microbiological failure, adverse events, and resistance development between the two treatment regimens. Further randomized controlled trials are needed to confirm these findings.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Faizan Abul Qais, Nagma Parveen, Iqbal Ahmad, Fohad Mabood Husain, Altaf Khan, Mohd Adil
Summary: Antimicrobial resistance is a significant challenge to public health, especially in developing countries. Recent research has identified quorum sensing as a process in which bacteria engage and regulate various functions. Pseudomonas aeruginosa, an opportunistic bacterial pathogen, plays a significant role in various medical conditions. This study found that azlocillin and moxalactam may be effective antibiotics for targeting the quorum sensing of P. aeruginosa.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Microbiology
Ashlan J. Kunz Coyne, Mohammad Alshaer, Anthony M. Casapao, Veena Venugopalan, Carmen Isache, Jason Ferreira, Christopher A. Jankowski
Summary: This study compared clinical outcomes in hospitalized patients with Pseudomonas aeruginosa pneumonia or bloodstream infection who received beta-lactam antibiotic infusions with and without the guidance of therapeutic drug monitoring. The results showed that therapeutic drug monitoring decreased the odds of treatment failure, but also increased the risk of infection-related readmissions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Christie M. Bertram, Michael Postelnick, Christian M. Mancini, Xiaoqing Fu, Yuqing Zhang, Lucas T. Schulz, Tanaya Bhowmick, Francesca Lee, Kimberly G. Blumenthal
Summary: The study found that using alternative antibiotics for surgical prophylaxis poses an increased risk of adverse events and surgical site infection compared to cefazolin. Additionally, patients with documented beta-lactam allergy were more likely to be prescribed clindamycin instead of cefazolin.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Tereza Stachurova, Hana Pikova, Martin Bartas, Jaroslav Semerad, Katerina Svobodova, Katerina Malachova
Summary: This study found that the technology and wastewater composition of municipal and village wastewater treatment plants have an impact on the accumulation of resistance genes in bacterial populations. The sedimentation processes of municipal WWTP1 were crucial for the accumulation of the blaTEM gene. NGS analysis revealed that Gammaproteobacteria dominated the ampicillin-resistant bacteria in the WWTP sedimentation tanks.
Article
Microbiology
Melissa Pitton, Simone Oberhaensli, Fiona Appiah, Jean-Luc Pagani, Anne Fournier, Stephan M. Jakob, Yok-Ai Que, David R. Cameron
Summary: This study reports a case of small-colony variant (SCV) emergence of Pseudomonas aeruginosa in a patient undergoing aminoglycoside treatment for burn wound infection, and confirms the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. The involvement of IspA in ubiquinone synthesis provides a possible link between electron transport and SCV formation in P. aeruginosa.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Hye-Ri Jung, Yu Jin Lee, Serim Hong, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee
Summary: Beta-lactam antibiotics are widely used in human and veterinary medicine, but their excessive use has led to the spread of deadly antibiotic-resistant bacteria. This study found that beta-lactam antibiotics were commonly prescribed in integrated broiler operations, and their use was associated with an increase in beta-lactam-resistant E. coli isolates. These findings highlight the importance of strengthening farm management practices and reducing antibiotic use.
Article
Pharmacology & Pharmacy
Amin Rakhshan, Nazanin Farahbakhsh, Ghamartaj Khanbabaee, Seyed Ahmad Tabatabaii, Saeed Sadr, Maryam Hassanzad, Mohammad Sistanizad, Farzaneh Dastan, Mahmoud Hajipour, Amir Reza Bahadori, Bahador Mirrahimi
Summary: This study evaluated the concurrent use of inhaled and intravenous aminoglycoside antibiotics for treating pulmonary exacerbation caused by Pseudomonas aeruginosa in cystic fibrosis patients. The results showed that this treatment method was safe and effective, and it improved patients' forced expiratory volume and treatment outcomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Mario Tumbarello, Enrico Maria Trecarichi, Alberto Corona, Francesco Giuseppe De Rosa, Matteo Bassetti, Cristina Mussini, Francesco Menichetti, Claudio Viscoli, Caterina Campoli, Mario Venditti, Andrea De Gasperi, Alessandra Mularoni, Carlo Tascini, Giustino Parruti, Carlo Pallotto, Simona Sica, Ercole Concia, Rosario Cultrera, Gennaro De Pascale, Alessandro Capone, Spinello Antinori, Silvia Corcione, Elda Righi, Angela Raffaella Losito, Margherita Digaetano, Francesco Amadori, Daniele Roberto Giacobbe, Giancarlo Ceccarelli, Ernestina Mazza, Francesca Raffaelli, Teresa Spanu, Roberto Cauda, Pierluigi Viale
CLINICAL INFECTIOUS DISEASES
(2019)
Review
Infectious Diseases
Elda Righi, Alessia Carnelutti, Matteo Bassetti
CURRENT OPINION IN INFECTIOUS DISEASES
(2019)
Review
Infectious Diseases
Matteo Bassetti, Alessandro Russo, Elda Righi, Elisabetta Dolso, Maria Merelli, Federica D'Aurizio, Assunta Sartor, Francesco Curcio
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2019)
Article
Infectious Diseases
Matteo Bassetti, Nadia Castaldo, Annamaria Cattelan, Cristina Mussini, Elda Righi, Carlo Tascini, Francesco Menichetti, Claudio Maria Mastroianni, Mario Tumbarello, Paolo Grossi, Stefania Artioli, Novella Carannante, Ludovica Cipriani, Davide Coletto, Alessandro Russo, Margherita Digaetano, Angela Raffaella Losito, Maddalena Peghin, Alessandro Capone, Stefano Nicole, Antonio Vena, Davide Pecori, Alessia Carnellutti, Filippo Givone, Elena Graziano, Maria Merelli, Barbara Cadeo, Stefano Verdenelli, Silvia Fabiani, Russo Gianluca, Alessandra Oliva, Maria Rosa Ciardi, Camilla Ajassa, Tiziana Tieghi, Mario Tumbarello, Francesca Raffaelli, Cristina Rovelli, Giorgia Caruana, Roberto Luzzati, Giulia Bontempo, Nicola Petrosillo, Giuliano Rizzardini, Massimo Coen, Matteo Passerini, Antonio Mastroianni, Filippo Urso, Maria Francesca Bianco, Guglielmo Borgia, Ivan Gentile, Alberto Enrico Maraolo, Massimo Crapis, Sergio Venturini, Giustino Parruti, Francesca Trave, Gioacchino Angarano, Sergio Carbonara, Michele Fabiano Mariani, Massimo Girardis, Antonio Cascio, Claudia Gioe, Marco Anselmo, Emanuele Malfatto
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Review
Infectious Diseases
Anna Maria Peri, Yohei Doi, Brian A. Potoski, Patrick N. A. Harris, David L. Paterson, Elda Righi
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2019)
Article
Immunology
Elda Righi, Alessia Carnelutti, Alessandro La Rosa, Assunta Sartor, Patrizia Tulissi, Tolinda Gallo, Federico Ivaldi, Matteo Bassetti
Article
Public, Environmental & Occupational Health
Matteo Bassetti, Alessandro Russo, Elda Righi, Elisabetta Dolso, Maria Merelli, Federica D'Aurizio, Assunta Sartor, Francesco Curcio
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2020)
Review
Infectious Diseases
Elda Righi, Tolinda Gallo, Anna Maria Azzini, Fulvia Mazzaferri, Maddalena Cordioli, Mara Merighi, Evelina Tacconelli
Summary: Immunisation in patients with altered immunocompetence is challenging due to limited data from vaccine trials, suboptimal vaccine efficacy, and safety concerns. Recommendations for this group are mainly based on expert consensus and may vary geographically, requiring personalized immunization schedules based on local guidelines, age, and type and stage of underlying diseases.
INFECTIOUS DISEASES AND THERAPY
(2021)
Review
Infectious Diseases
Luigia Scudeller, Elda Righi, Margherita Chiamenti, Damiano Bragantini, Giulia Menchinelli, Paolo Cattaneo, Christian G. Giske, Thomas Lodise, Maurizio Sanguinetti, Laura J. Piddock, Francois Franceschi, Sally Ellis, Elena Carrara, Alessia Savoldi, Evelina Tacconelli
Summary: The efficacy of combination therapy for carbapenem-resistant Gram-negative bacilli (CR-GNB) infections remains controversial. In vitro studies suggest that combinations of polymyxins and carbapenems show high or moderate synergism against CR-GNB. Well-designed in vitro studies are crucial for guiding the selection of combination therapies in clinical trials and improving the armamentarium against carbapenem-resistant bacteria.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Elda Righi, Massimo Mirandola, Fulvia Mazzaferri, Elisa Razzaboni, Amina Zaffagnini, Anna Erbogasto, Ilaria Dalla Vecchia, Nina Auerbach, Federico Ivaldi, Maria Mongardi, Pietro Minuz, Michele Milella, Sara Mehrabi, Oliviero Olivieri, Domenico Girelli, Enrico Polati, Claudio Micheletto, Evelina Tacconelli
Summary: The study identified male gender, age, hospital admission, and comorbidities as important predictors of impaired general health among COVID-19 patients. Fatigue and breathlessness were the most frequently reported symptoms in the long-term impact of COVID-19.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Infectious Diseases
Elda Righi, Massimo Mirandola, Fulvia Mazzaferri, Giuditta Dossi, Elisa Razzaboni, Amina Zaffagnini, Federico Ivaldi, Alessandro Visentin, Lorenza Lambertenghi, Cinzia Arena, Claudio Micheletto, Davide Gibellini, Evelina Tacconelli
Summary: Residual symptoms can persist for several months after COVID-19, affecting both physical and mental wellbeing. Age, hospitalization, and symptom duration are predictors of symptom persistence. This study helps identify target populations and plan long-term recovery interventions.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Maddalena Giannella, Elda Righi, Renato Pascale, Matteo Rinaldi, Natascia Caroccia, Chiara Gamberini, Zaira R. Palacios-Baena, Giulia Caponcello, Maria Cristina Morelli, Mariarosa Tame, Marco Busutti, Giorgia Comai, Luciano Potena, Elena Salvaterra, Giuseppe Feltrin, Umberto Cillo, Gino Gerosa, Mara Cananzi, Salvatore Piano, Elisa Benetti, Patrizia Burra, Monica Loy, Lucrezia Furian, Gianluigi Zaza, Francesco Onorati, Amedeo Carraro, Fiorella Gastaldon, Maurizio Nordio, Samir Kumar-Singh, Mahsa Abedini, Paolo Boffetta, Jesus Rodriguez-Bano, Tiziana Lazzarotto, Pierluigi Viale, Evelina Tacconelli
Summary: This study compared the antibody response to mRNA COVID-19 vaccines in solid organ transplant recipients and healthcare workers. The results showed that healthcare workers had significantly higher antibody levels compared to solid organ transplant recipients, and the antibody levels in both groups varied over time. Specific factors and medications may influence the antibody response in solid organ transplant recipients.
Review
Pharmacology & Pharmacy
Elda Righi, Alessandro Visentin, Marco Meroi, Elena Carrara, Evelina Tacconelli
Summary: Dalbavancin is a safe and well-tolerated drug for the treatment of acute bacterial skin and skin-structure infections. Common adverse effects include gastrointestinal symptoms, infusion reaction, and hypersensitivity. Further research is needed for the off-label use of dalbavancin.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Elda Righi, Lorenza Lambertenghi, Anna Gorska, Concetta Sciammarella, Federico Ivaldi, Massimo Mirandola, Assunta Sartor, Evelina Tacconelli
Summary: This study found that COVID-19 patients receiving antibiotic treatment may shift the gut microbiome composition towards opportunistic bacteria (OBs), particularly Enterococcus. The treatment-induced dysbiosis may impact infections and long-term consequences, providing important clues to the role of gut homeostasis in COVID-19 recovery.
Review
Infectious Diseases
Elda Righi, Luigia Scudeller, Massimo Mirandola, Alessandro Visentin, Nico T. Mutters, Marco Meroi, Anna Schwabe, Anna Erbogasto, Gianluca Vantini, Elizabeth L. A. Cross, Maddalena Giannella, Xavier Guirao, Evelina Tacconelli
Summary: This study conducted a systematic review and meta-analysis and found that patients colonised with extended-spectrum cephalosporin-resistant Enterobacterales (ESCR-E) before surgery are more likely to develop postoperative infections. Preoperative screening for ESCR-E in adult inpatients may help reduce the incidence of surgical site infections.
INFECTIOUS DISEASES AND THERAPY
(2023)