Review
Biochemistry & Molecular Biology
Antony Hoarau, Myriam Polette, Christelle Coraux
Summary: Hyaluronic acid (HA) is a major component of the extracellular matrix with anti-inflammatory and immunomodulatory functions in the lungs. The size of HA determines its pro-inflammatory or anti-inflammatory effects. The interactions between HA and hyaladherins play a role in HA activities. LMW-HA is involved in pulmonary innate immunity by activating various cells, making it a potential therapeutic target for inflammatory respiratory diseases.
Article
Medicine, Research & Experimental
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope K. Blakely, Ayse Bilge Ozel, Sarah E. Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekumulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thorner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Soren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, Gunnar Engstrom, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Summary: The study using epidemiologic, genetic, and experimental approaches found that suPAR is a pathogenic factor for atherosclerosis, with its levels strongly associated with cardiovascular outcomes and predictive of coronary artery calcification. The missense variant rs4760 in the PLAUR gene leads to higher suPAR levels, and Mendelian randomization analysis confirms a causal relationship between genetically predicted suPAR levels and atherosclerotic phenotypes. In experimental models, increased suPAR levels modulate monocyte function to promote atherosclerosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Shengli Ding, Jing Yang, Xuehuan Feng, Aseem Pandey, Rola Barhoumi, Dongmei Zhang, Samantha L. Bell, Yue Liu, Luciana Fachini da Costa, Allison Rice-Ficht, Robert O. Watson, Kristin L. Patrick, Qing-Ming Qin, Thomas A. Ficht, Paul de Figueiredo
Summary: This study reveals that the recruitment of host AIC proteins to forming phagosomes depends on the activity of CD44, which is crucial for the internalization of fungal pathogens into host cells.
Article
Cardiac & Cardiovascular Systems
W. Coles Keeter, Alina K. K. Moriarty, Rachel Akers, Shelby Ma, Marion Mussbacher, Jerry L. L. Nadler, Elena V. V. Galkina
Summary: This study investigates the role of signal transducer and activator of transcription 4 (STAT4) in neutrophils during advanced atherosclerosis. STAT4 deficiency reduces plaque burden and improves plaque stability in mice. Additionally, STAT4 deficiency decreases neutrophil activation and attenuates neutrophil trafficking to atherosclerotic plaques.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Aditya Kaul, Walker D. Short, Sundeep G. Keswani, Xinyi Wang
Summary: Hyaluronic acid plays a crucial role in wound healing by interacting with the immune system, with its molecular weight determining its immune-modulating effects on the repair process.
Article
Chemistry, Multidisciplinary
C. -S. Lee, T. W. Kim, Y. Kang, Y. Ju, J. Ryu, H. Kong, Y. -S. Jang, D. E. Oh, S. J. Jang, H. Cho, S. Jeon, J. Kim, T. H. Kim
Summary: This study developed hyaluronic acid (HA)-modified dendrimer encapsulating gold nanoparticles (AuDEN) as a nanocarrier for effective targeted drug delivery in ovarian cancer treatment. The nanocarriers efficiently loaded doxorubicin (DOX) and released it in an acidic tumor microenvironment. The nanocarriers exhibited enhanced cytotoxicity to cancer cells and showed promising results in inhibiting tumor growth in an in vivo model.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Biomedical
Josh Karam, Breahna J. Singer, Hiromi Miwa, Limin H. Chen, Kajal Maran, Mahdi Hasani, Sarahi Garza, Bianca Onyekwere, Hsin-Chih Yeh, Song Li, Dino Di Carlo, Stephanie K. Seidlits
Summary: This study demonstrates that high molecular weight hyaluronic acid (HMW HA) promotes viability and tube formation in human cerebral microvascular endothelial cells (HCMVECs), both in soluble and crosslinked forms. The HMW HA in crosslinked form also supports vascularization through inducing CD44 receptor clustering. This finding is significant for the design of hyaluronic acid hydrogels with predictable bioactivity.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Niranjan G. Kotla, Isma Liza Mohd Isa, Aitor Larranaga, Balaji Maddiboyina, Samantha K. Swamy, Gandhi Sivaraman, Praveen K. Vemula
Summary: In recent years, there has been a significant expansion in the research and clinical applications of hyaluronic acid-based scaffolds, medical devices, and bioconjugate systems. These developments are driven by the abundance of hyaluronic acid in mammalian tissues and its potential for chemical modifications. This review summarizes the importance of chemical modifications of hyaluronic acid, various advancements in bioconjugate derivatives, and their potential advantages in terms of physicochemical and pharmacological properties.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Ejaj Ahmad, Asgar Ali, Munazza Tamkeen Fatima, Nimisha, Apurva, Arun Kumar, Mamta P. Sumi, Real Sumayya Abdul Sattar, Bhawna Mahajan, Sundeep Singh Saluja
Summary: This article summarizes the recent 5-year efforts in the development of ligands-decorated biodegradable nanocarriers as a targeted nanomedicine approach, which has shown great promise in the treatment of cancer.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Haojue Wang, Wanfei Shao, Xianyi Lu, Chunxia Gao, Ling Fang, Xiaojun Yang, Peizhi Zhu
Summary: A novel nano-drug delivery system, HA-MA-MTX, was developed in this study to enhance the accumulation of MTX in tumors and minimize toxicity to normal tissues. The system combines MTX as a tumor-targeting ligand, HA as another tumor-targeting ligand, and MA as an anti-inflammatory agent. In vitro experiments showed that HA-MA-MTX nanoparticles effectively inhibited K7 cancer cells while exhibiting lower toxicity to normal MC3T3-E1 cells compared to MTX.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Raquibun Nisha, Pranesh Kumar, Umesh Kumar, Nidhi Mishra, Priyanka Maurya, Priya Singh, Heena Tabassum, Alka, Samipta Singh, Anupam Guleria, Shubhini A. Saraf
Summary: Hyaluronic acid-functionalised imatinib mesylate cubosomes (HA-IM CBs) show promising anti-hepatic cancer activity with CD44 targeting capability, higher drug concentration, and improved pharmacokinetics. These cubosomes stimulate the CD44-regulated mitochondrial apoptotic pathway, demonstrating their potential against HCC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Saniya Salathia, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, Roberta Censi
Summary: The nervous and immune systems are closely related in causing inflammation and pain. Macrophages play a crucial role in modulating inflammation to induce neuropathic pain. Varying the molecular weight of hyaluronic acid can resolve inflammation and relieve pain and inflammation by using HA-based drug delivery nanosystems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Stefania Cannito, Valeria Bincoletto, Cristian Turato, Patrizia Pontisso, Maria Teresa Scupoli, Giorgia Ailuno, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Claudia Bocca
Summary: This study proposes the use of HA- and PEGylated-liposomes as potential treatments for hepatocellular carcinoma (HCC). The up-regulation of CD44 in HCC patients and a murine model suggests the involvement of this receptor in HCC progression. The experimental results show that HA-liposomes are more easily internalized by cells that over-express CD44, while PEG-modified liposomes are rapidly taken up by macrophages and induce M1 polarization in THP1 cells.
Article
Biochemistry & Molecular Biology
Takanari Sato, Remina Shirai, Mikinori Isogai, Masahiro Yamamoto, Yuki Miyamoto, Junji Yamauchi
Summary: Hyaluronic acid, a component of the central nervous system (CNS), has been found in lesions of multiple sclerosis (MS) patients and mouse models of autoimmune encephalomyelitis (EAE). This study demonstrates that hyaluronic acid and its receptor CD44 play a role in inhibiting the differentiation of oligodendroglial cells, and this effect requires the involvement of transmembrane protein 2 (TMEM2), a cell surface hyaluronidase. These findings provide insights into the physiological and pathological effects of hyaluronic acid on oligodendroglial cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Afsana Sheikh, Sahim Aziz Hazari, Nagashekhara Molugulu, Saad Ali Alshehri, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: This article investigates the potential of chitosan nanoparticles loaded with gallic acid (GA) for the treatment of psoriasis. The study found that coating the nanoparticles with hyaluronic acid (HA) slightly increased the particle size but enhanced their inhibitory effect on cells. In vivo experiments demonstrated the potential of HA-modified nanoparticles in restricting psoriasis. Further research should explore the application of HA-modified nanoparticles in the treatment of other skin-related conditions.
ENVIRONMENTAL RESEARCH
(2023)