Article
Multidisciplinary Sciences
Sasikaan Nimmaanrat, Benjalak Charuenporn, Mark P. Jensen, Alan F. Geater, Jutarat Tanasansuttiporn, Thavat Chanchayanon
Summary: This study aimed to evaluate the potential anxiolytic effects of premedication with pregabalin compared to diazepam and placebo. The findings showed that neither pregabalin nor diazepam significantly reduced preoperative anxiety compared to placebo, despite causing higher levels of sedation. Clinicians must consider the benefits and risks of using these two drugs.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Darryl C. Gidyk, Mustansir Diwan, Flavia Venetucci Gouveia, Peter Giacobbe, Nir Lipsman, Clement Hamani
Summary: The study found that deep brain stimulation in the ventromedial prefrontal cortex of rats improves fear and anxiety behaviors by reducing CB1 receptor expression, with CB1 antagonist unable to fully counteract these effects.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Yumi Aoki, Yoshikazu Takaesu, Ken Inada, Hiroki Yamada, Tomohiko Murao, Toshiaki Kikuchi, Masahiro Takeshima, Masayuki Tani, Kazuo Mishima, Tempei Otsubo
Summary: The aim of this study was to develop a decision aid for individuals with anxiety disorders who are considering tapering benzodiazepine anxiolytics. The decision aid includes options for tapering with or without cognitive behavioral therapy and was found to be acceptable among stakeholders, including patients and healthcare providers.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Plant Sciences
Johane Gericke, Brian H. Harvey, Lesha Pretorius, Tracey Ollewagen, Rohan M. Benecke, Carine Smith
Summary: This study determined the effective concentration of a Sceletium tortuosum (ST) extract with anxiolytic and antidepressant effects using zebrafish larvae as a model. The results showed that the alkaloid mesembrine contributed significantly to the anxiolytic effects of the extract. However, the contribution of individual alkaloids to the antidepressant effects could not be determined. Further investigation into the mechanisms of action and potential synergistic effects of ST alkaloids is warranted.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Clinical Neurology
Alexander T. Gallo, Gary K. Hulse
Summary: The chronic stress and chronic exposure to and withdrawal from allopregnanolone in anxiety disorders result in alterations in GABA(A) receptor function, which can be corrected by flumazenil and may exhibit anxiolytic properties.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Paul Aime Noubissi, Queendoline Njilifac, Michel Archange Fokam Tagne, Mireille Sylviane Dongmo Nguepi, Angele Foyet Fondjo, Nadege Kouemou Emegam, Joseph Ngakou Mukam, Roger Zintchem, Henri Wambe, Gaetan Oliver Fankem, Agathe Fotio Tonfack, Jean Paul Toukala, Germain Taiwe Sotoing, Rene Kamgamg
Summary: This study investigated the antioxidant and anxiolytic effects of Moringa oleifera leaves aqueous extract on acetic acid-induced colitis in rats. The results showed that the extract can alleviate the pathophysiology of colitis, reduce oxidative stress, and have anxiolytic effects. These findings suggest that Moringa oleifera could be a potential source of drugs for treating anxiety and oxidative stress associated with ulcerative colitis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Caroline B. Buchanan, Jennifer L. Stallworth, Aubin E. Joy, Rebekah E. Dixon, Alexandra E. Scott, Arthur A. Beisang, Timothy A. Benke, Daniel G. Glaze, Richard H. Haas, Peter T. Heydemann, Mary D. Jones, Jane B. Lane, David N. Lieberman, Eric D. Marsh, Jeffrey L. Neul, Sarika U. Peters, Robin C. Ryther, Steve A. Skinner, Shannon M. Standridge, Walter E. Kaufmann, Alan K. Percy
Summary: This study aims to investigate the frequency and clinical features of anxiety-like behavior in individuals with Rett syndrome (RTT). The results show that anxiety-like behavior is common in individuals with RTT, and it is a significant concern for both parents and caregivers. Older individuals and those with mild MECP2 variants are more likely to receive treatment for anxiety. Improving the diagnosis and treatment of anxiety in RTT should be a priority for future studies and clinical care.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Rodrigues Garcia, Paulo De Tarso Cavalcante Freire, Antonio Wlisses da Silva, Maria Kueirislene Amancio Ferreira, Emanuela de Lima Reboucas, Francisco Rogenio Silva Mendes, Emanuelle Machado Marinho, Marcia Machado Marinho, Alexandre Magno Rodrigues Teixeira, Emmanuel Silva Marinho, Paulo Nogueira Bandeira, Jane Eire Silva Alencar de Menezes, Helcio Silva dos Santos
Summary: Anxiety and epilepsy are worldwide health concerns, and the current treatments using Benzodiazepines have serious side effects. Therefore, the discovery of new drugs for these conditions is necessary. This study evaluated the anxiolytic and anticonvulsant effects of an ibuprofen derivative (IBUACT) in adult Zebrafish and its interaction with the GABAergic receptor through virtual studies. The results showed that IBUACT exhibited similar anxiolytic behavior to Diazepam, and it delayed PTZ-induced seizures. Additionally, IBUACT strongly bound in the Diazepam region of GABA(A). This study also highlighted the potential pharmacological applications of ibuprofen derivatives in central nervous system pathologies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Luming Cui, Qian Zhang, Yifan Zhang, Tingjie Li, Menghan Li, Jinye Yuan, Zhiyi Wu, Yue Zhang, Hui Kong, Huihua Qu, Yan Zhao
Summary: This study identified a novel type of carbon dots (CMRC-CDs) derived from the decoction of Chrysanthemum morifolium Ramat Carbonisata and characterized their morphological structure and functional groups. The anti-anxiety effects of CMRC-CDs were evaluated in mice, and it was found that CMRC-CDs reduced anxiety-like behavior induced by mCPP. The anxiolytic effects may be attributed to the modulation of neurotransmitters and HPA axis hormones.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yixiao Luo, Rafi Ullah, Jinfeng Wang, Yuru Du, Shihao Huang, Li Meng, Yuan Gao, Miao Gong, Ewa Galaj, Xi Yin, Haishui Shi
Summary: The study demonstrated that carbon monoxide (CO) has significant antidepressant and anxiolytic effects, providing protection through activation of HO-1 and exogenous CO administration. This research revealed a novel function of the HO-1/CO system, offering a promising therapeutic target for the treatment of depression and anxiety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Isabelle Ryden, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Oyvind Salvesen, Asgeir Store Jakola
Summary: The study found that the use of antidepressants, sedatives, and anti-epileptic drugs increases significantly after a diagnosis of LGG, with females and later index years being additional predictors for increased use of antidepressants.
Article
Endocrinology & Metabolism
Hossam Kamli, Mehedi Hasan Bappi, Tawhida Islam, Rajib Hossain, M. D. Munnaf Hossen, Abdullah Al Faruq, Joao Arthur de Oliveira Borges, Isaac Moura Araujo, Ray Silva de Almeida, Henrique Douglas Melo Coutinho, Catarina Martins Tahim, Elaine Cristina Pereira Lucetti, Muhammad Torequl Islam
Summary: The ethanolic leaf extract of U. sinuata demonstrates antioxidant, anti-inflammatory, and anxiolytic activity, making it a potential source of plant-based active compounds for treating inflammation, oxidative stress, and neurological diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Food Science & Technology
Md. Nayem Mia, Shanita Zaman Smrity, Mehedi Hasan Bappi, Hossam Kamli, Tawhida Islam, Abdullah Al Shamsh Prottay, Md Showkoth Akbor, Md Abdul Latif, Shoriful Islam, Kushal Bhakta, Manik Chandra Shill, Francisco Claudeni Pereira de Sousa, Gilberto de Luna, Henrique Douglas Melo Coutinho, Muhammad Torequl Islam
Summary: This study evaluated the possibility of succinic acid in managing anxiety through in vivo and in silico studies. The results suggest that succinic acid may have relaxing effects on mice and interact with GABAA receptor subunits, indicating its potential as an anxiolytic drug candidate.
Article
Immunology
Zhi-Heng Zheng, Xing-Cheng Lin, Ying Lu, Shi-Rui Cao, Xu-Kai Liu, Dong Lin, Fan-Hua Yang, Yang -Bo Zhang, Ping Hu, Wen-Hua Zhang
Summary: Increasing evidence suggests that immune system alterations contribute to the development of anxiety disorders, and inhibiting neuroinflammation may be an effective therapeutic strategy. Harmine, a compound found in medicinal plants, has been reported to have anti-inflammatory and potential anxiolytic effects. However, the mechanisms underlying these effects are not fully understood. This study showed that harmine alleviates anxiety-like behaviors by reducing neuroinflammation and restoring neuronal plasticity in the basolateral amygdala.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Lourdes Santiago-Lopez, Arantxa Almada-Corral, Hugo S. Garcia, Veronica Mata-Haro, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba, Adrian Hernandez-Mendoza
Summary: This study aimed to assess the potential antidepressant- and anxiolytic-like effects of huauzontle fermented by Lactiplantibacillus plantarum Lp22. The results showed that mice receiving both fermented and unfermented huauzontle exhibited more brave and active behaviors in the behavioral tests, and had lower oxidative stress index. These findings suggest the potential therapeutic applications of fermented huauzontle on depression and anxiety-like behaviors, possibly mediated by antioxidant and anti-inflammatory mechanisms.