Article
Infectious Diseases
Hideo Kato, Mao Hagihara, Nobuhiro Asai, Yuichi Shibata, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
Summary: This study found through a meta-analysis of RCTs and CSs that LZD has significantly higher clinical cure and microbiological eradication rates compared to VCM in the treatment of proven MRSA pneumonia. However, there was no significant difference in mortality and adverse events between VCM and LZD.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Infectious Diseases
Samantha D. Yeager, Justin E. Oliver, Mahmoud A. Shorman, Laurence R. Wright, Michael P. Veve
Summary: This study compared the effectiveness and safety of oral step-down linezolid with standard parenteral therapy in MRSA bloodstream infection. The results showed that linezolid had similar clinical outcomes and safety profiles compared to parenteral therapy, with fewer adverse events requiring re-hospitalization. Additional research is needed to explore the use of step-down linezolid in MRSA bloodstream infection.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Takayuki Katsube, David P. Nicolau, Keith A. Rodvold, Richard G. Wunderink, Roger Echols, Yuko Matsunaga, Anju Menon, Simon Portsmouth, Toshihiro Wajima
Summary: This study assessed the intrapulmonary pharmacokinetic profile of cefiderocol in hospitalized, mechanically ventilated pneumonia patients, showing that cefiderocol can penetrate the epithelial lining fluid in the lungs with concentrations sufficient to treat Gram-negative bacteria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Emergency Medicine
Anthony J. Renzoni, Gary D. Peksa, Joshua M. DeMott
Summary: A study of 116 emergency department patients found that conducting MRSA nasal screening for pneumonia patients did not decrease the duration of anti-MRSA antibiotics. Secondary outcomes showed no significant differences either. Therefore, there is currently no need for ED providers to consider MRSA nasal screening for patients admitted to general medicine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Infectious Diseases
Yanlei Xu, Bingjie Wang, Huilin Zhao, Xinyi Wang, Lulin Rao, Wenxiu Ai, Jingyi Yu, Yinjuan Guo, Xiaocui Wu, Fangyou Yu, Shuying Chen
Summary: The study found that all MRSA isolates remained sensitive to vancomycin, teicoplanin, linezolid and daptomycin, but an increase in MIC50 and MIC90 was observed for linezolid.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Catia Cilloniz, Cristina Dominedo, Albert Gabarrus, Carolina Garcia-Vidal, Jose Becerril, Diego Tovar, Estela Moreno, Juan M. Pericas, Carmen Rosa Vargas, Antoni Torres
Summary: This study aimed to describe the prevalence, risk factors, and outcomes of MSSA community-acquired pneumonia and found that MSSA CAP patients had higher 30-day mortality than pneumococcal CAP patients, with MSSA being an independent factor of mortality.
JOURNAL OF INFECTION
(2021)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Ya-Xin Fan, Meng-Ting Chen, Nan-Yang Li, Xiao-Fen Liu, Min-Jie Yang, Yuan-Cheng Chen, Xiao-Yu Liang, Ju-Fang Wu, Bei-Ning Guo, Si-Chao Song, Yong-Qiang Zhu, Feng-Ying Zhang, Jing-Qing Hang, Sheng-Bin Wu, Bo Shen, Hua-Yin Li, Qin Wang, Xu-Ming Luo, Qing-Ge Chen, Hui-Fang Zhang, Rui-Lan Wang, Li-Hua Shen, Feng-Ming Fu, Xiao-Lian Song, Jing Zhang
Summary: This study analyzed risk factors for vancomycin failure in patients with MRSA pneumonia and found that factors such as vancomycin dosage, peak concentration, and specific genes were associated with clinical improvement and eradication of the bacteria. ST5 strains were identified as potential predictors of bacterial persistence and were associated with higher levels of resistance and virulence genes.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Jang Ho Lee, Myeong Geun Choi, Hyung Jun Park, Ho Cheol Kim, Chang-Min Choi
Summary: This study compared the efficacy and safety of vancomycin and teicoplanin in patients with methicillin-resistant Staphylococcus aureus pneumonia. The results showed that vancomycin had lower clinical failure rates, discontinuation rates due to treatment failure, and mortality rates compared to teicoplanin. However, it had higher rates of side effects. Therefore, clinicians need to consider the efficacy and potential side effects of these drugs before prescribing.
BMC INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Katharina Rox, Tim Becker, Andrea Schiefer, Miriam Grosse, Alexandra Ehrens, Rolf Jansen, Tilman Aden, Stefan Kehraus, Gabriele M. Koenig, Anna K. Krome, Marc P. Huebner, Karl G. Wagner, Marc Stadler, Kenneth Pfarr, Achim Hoerauf
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a high priority pathogen organism, causing significant global mortality. The natural product CorA, currently in preclinical development, demonstrates effectiveness against MRSA in vitro. This study evaluates the pharmacokinetics and pharmacodynamics of CorA, suggesting its potential for MRSA and MSSA-related infections.
Article
Microbiology
Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad, Mona Johannessen, Kristin Hegstad, Victor Nizet, Fatemeh Askarian
Summary: This study revealed that MRSA-derived MVs are capable of reducing the pathogen's susceptibility to VAN, thereby increasing its resistance to treatment, particularly in interactions with human neutrophils. Additionally, the elevated expression of proteins associated with antibiotic resistance in MVs may further impact MRSA's resistance.
Article
Infectious Diseases
A. J. Heffernan, F. B. Sime, S. Mohd Sazlly Lim, S. Adiraju, S. C. Wallis, J. Lipman, G. D. Grant, J. A. Roberts
Summary: This study investigated the pharmacodynamics of ceftriaxone against methicillin-susceptible Staphylococcus aureus (MSSA) and determined the optimal dosage. The results showed that only a high ceftriaxone dose of 2 g twice daily achieved bacterial killing and sustained inhibition of bacterial growth.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Robby Markwart, Niklas Willrich, Tim Eckmanns, Guido Werner, Olaniyi Ayobami
Summary: The study found that resistance to linezolid and daptomycin in VREF and MRSA between 2014 and 2018 was relatively low, indicating the continued effectiveness of these last-resort antibiotics in Europe. However, efforts to monitor and contain antimicrobial resistance should be strengthened at regional and national levels.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Siheng Wang, Chang Cai, Yingbo Shen, Chengtao Sun, Qingxin Shi, Ningjun Wu, Shufang Zheng, Jiao Qian, Rong Zhang, Hongwei Zhou
Summary: Contezolid exhibits potent activity against MRSA and VRE strains. It shows similar or slightly better antimicrobial activity compared to linezolid. Contezolid may have potential benefits for treating infections caused by MRSA and VRE pathogens.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Jin Liang, Yuanfang Hu, Mingxia Fu, Na Li, Fengxia Wang, Xiaojun Yu, Bing Ji
Summary: The study investigated the molecular epidemiology of Staphylococcus aureus (S. aureus) in patients from the Yellow River Delta region and examined antibiotic resistance profiles in different genetic backgrounds. Antibiotic susceptibility testing, spa typing, and agr typing were conducted on all 204 strains. The results identified 39 MRSA strains and 22 hVISA isolates. The majority of MRSA isolates belonged to agrI and were associated with type IV SCCmec. The most common genotypes among MRSA population were ST59-t437-agrI-IVa and ST72-t2431-agrI-IVF. The study highlights the genetic diversity and drug resistance patterns among MSSA strains exhibiting phenotypic hVISA.
INFECTION AND DRUG RESISTANCE
(2023)