Article
Medicine, General & Internal
Yichi Zhang, James M. Wilkins, Lily Gui Bessette, Cassandra York, Vincent Wong, Kueiyu Joshua Lin
Summary: This retrospective cohort study investigated the discontinuation rates and patient characteristics of antipsychotic medications (APMs) used to treat delirium following infection-related hospitalization among older US adults. The study found that the discontinuation rate of haloperidol was significantly higher compared to atypical APMs, and there was an increasing trend in haloperidol discontinuation rates in recent years.
Article
Oncology
Rajat Garg, Sachin Kumar Saxena, Vibha Singh, Sabreen Bashir, Anuka Sharma, Varun Sharma
Summary: This study investigates the metabolizing status of olanzapine and risperidone in Indian schizophrenic individuals. The results show a high frequency of slow metabolizers among schizophrenic patients. The genetic pool of Indian schizophrenic individuals exhibits variability compared to global populations.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Psychiatry
Hui Wu, Spyridon Siafis, Tasnim Hamza, Johannes Schneider-Thoma, John M. Davis, Georgia Salanti, Stefan Leucht
Summary: This study conducted a meta-analysis to investigate the association between antipsychotic doses and weight gain. The results showed that different second-generation antipsychotics have varying propensities to cause weight gain, and their dose-response curves also differ in shape. This information is crucial for dosing decisions in clinical practice.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Pharmacology & Pharmacy
Mikkel Hojlund, Christoph U. Correll
Summary: Long-acting injectable antipsychotics (LAIs) are effective and underutilized in the treatment of schizophrenia and severe mental illnesses. Prescribing information mainly focuses on initiating treatment from oral formulations, but guidance is needed for scenarios such as switching from other oral antipsychotics or other LAIs.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Chao Zhang, Dongdong Zheng, Weijing Feng, Huanji Zhang, Feng Han, Wanbing He, Aiting Liu, Hui Huang, Jie Chen
Summary: The study found a negative association between aortic calcification and APD dose in schizophrenia patients, with olanzapine appearing to play a key role in the relationship between aortic calcification and APD treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mohamed Ismail, Thomas Straubinger, Hiroyuki Uchida, Ariel Graff-Guerrero, Shinichiro Nakajima, Takefumi Suzuki, Fernando Caravaggio, Philip Gerretsen, David Mamo, Benoit H. Mulsant, Bruce G. Pollock, Robert Bies
Summary: The study developed a software tool for predicting dopamine D-2 receptor occupancy using sparse plasma concentration measurements, providing clinicians with a convenient way to explore treatment strategies in patients with schizophrenia. The software demonstrates high accuracy and accessibility.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Meritxell Tost, Alex Gonzalez-Rodriguez, Raquel Aguayo, Aida Alvarez, Itziar Montalvo, Juan David Barbero, Rosa Gabernet, Eduard Izquierdo, Igor Merodio, Jose Antonio Monreal, Diego Palao, Javier Labad
Summary: Switching from risperidone to paliperidone palmitate may be associated with improved social functioning and cognitive abilities in patients with schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Cristina Delgado-Sallent, Pau Nebot, Thomas Gener, Amanda B. Fath, Melina Timplalexi, M. Victoria Puig
Summary: Neural synchrony and functional connectivity are disrupted in schizophrenia. Atypical antipsychotic drugs, but not typical antipsychotic drugs, can reduce prefrontal and cortical-hippocampal hypersynchrony induced by psychosis-like states, suggesting that atypical antipsychotic drugs target prefrontal-hippocampal pathways for antipsychotic action. Serotonin receptors may play a selective role in the distinct effects of atypical antipsychotic drugs compared to typical antipsychotic drugs.
Article
Pharmacology & Pharmacy
Jason Seebaluck, Michael A. A. Downes, Jared Brown, Keith Harris, Katherine Z. Z. Isoardi, Betty S. S. Chan
Summary: This study investigated the clinical features and treatment approach of olanzapine post-injection delirium/sedation syndrome (PDSS). The symptoms of PDSS mainly involve anticholinergic effects and have a short duration. Supportive care is the most common treatment, while bromocriptine and rivastigmine may alleviate symptoms, but further studies are needed for validation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Neurosciences
Sidhant Chopra, Alex Fornito, Shona M. Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J. Wood, Patrick McGorry
Summary: This study aimed to differentiate between illness-related brain volume changes and medication-related changes within the first 3 months of treatment. It was found that antipsychotic medication and placebo had different effects on the pallidum volume, with patients showing increased volume and healthy controls showing no change. This suggests that psychotic illness and antipsychotic exposure have distinct effects on brain volume.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Olga Plaza, Piotr Galecki, Agata Orzechowska, Malgorzata Galecka, Justyna Sobolewska-Nowak, Agata Szulc
Summary: Schizophrenia is a complex psychiatric disorder affected by both genetic and environmental factors. Pharmacogenetic research can help identify genetic variations that impact the response to antipsychotic medications, leading to more personalized and effective treatments. Genes involved in pharmacokinetics, as well as dopamine, serotonin, and glutamate neurotransmission, have been found to have a significant impact on antipsychotic response.
Article
Medicine, General & Internal
Giammarco Cascino, Rossella Ceres, Alessio Maria Monteleone, Paola Bucci, Giulia Maria Giordano, Silvana Galderisi, Palmiero Monteleone
Summary: This study aimed to investigate the switching of antipsychotic medications in people with schizophrenia and analyze potential predictors. Over a four-year period, 34.9% of the participants switched their medication. The use of first-generation antipsychotics and the presence of extrapyramidal symptoms at baseline were associated with switching antipsychotic classes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lujie Yang, Xia Qi
Summary: The study demonstrates that the combination of risperidone and olanzapine in the treatment of schizophrenia can significantly improve cognitive function, show significant therapeutic efficacy, and induce fewer adverse reactions.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Rajat Garg, Sachin Kumar Saxena, Vibha Singh, Sabreen Bashir, Anuka Sharma, Varun Sharma
Summary: Genetic variations play a significant role in drug responses and side effects. Pharmacogenomics has potential in disorders like schizophrenia, but data on pharmacogenomics of schizophrenia are limited. We aimed to examine the genetic variants and metabolizing status of CYP1A1 and RGS4 in 94 Indian schizophrenic individuals.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Chih-Sung Liang, Tung-Ping Su, Ming-Hsien Hsieh, Chau-Shoun Lee, Joseph Kuo, Nan-Ying Chiu, Po-See Chen, Yung-Chieh Yen, Ya-Mei Bai
Summary: The study developed nine consensus recommendations for safely switching from oral or long-acting injectable atypical antipsychotics to Aripiprazole long-acting once-monthly (AOM), including dose adjustment and considerations for pregnancy/breastfeeding. An 80% agreement among panel members was required for final adoption of the recommendations, highlighting the importance of expert consensus in guiding safe medication transitions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)