Review
Clinical Neurology
John Dimar, Erica F. Bisson, Sanjay Dhall, James S. Harrop, Daniel J. Hoh, Basma Mohamed, Marjorie C. Wang, Praveen Mummaneni
Summary: Osteoporosis is a common bone disease in the elderly, and preoperative diagnosis and treatment are crucial for postoperative outcomes. Experts recommend preoperative testing for osteoporosis through dual-energy X-ray absorptiometry scan, computed tomography scan, and serum vitamin D3 level to predict an increased risk of adverse events after surgery.
Review
Biochemistry & Molecular Biology
Ligia J. Dominguez, Mario Farruggia, Nicola Veronese, Mario Barbagallo
Summary: Research on vitamin/hormone D deficiency has been receiving widespread attention in recent years due to its confirmed role in various enzymatic, metabolic, physiological, and pathophysiological processes related to human organs and systems. The global prevalence of modest-to-severe vitamin D deficiency has sparked growing interest in the importance of optimal vitamin D levels for bone, muscle, and overall health, as well as for the effectiveness of bone-forming treatments. Current strategies to address deficiency include food supplementation with vitamin D or the use of vitamin D supplements.
Article
Endocrinology & Metabolism
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jan Hughes-Austin, Lindsay M. Miller, Jessica O. Becker, Stephen B. Kritchevsky, Michael G. Shlipak, Mark J. Sarnak, Joachim H. Ix
Summary: Among a diverse cohort of community-dwelling older adults, a lower VMR was more strongly associated with both loss of bone mineral density (BMD) and fracture risk compared with 25(OH)D-3. Further trials are needed to evaluate the VMR as a therapeutic target in individuals at risk for worsening BMD and fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Eun Ji Lee, Cheol Min Shin, Dong Ho Lee, Kyungdo Han, Sang Hyun Park, Yoo Jin Kim, Hyuk Yoon, Young Soo Park, Nayoung Kim
Summary: Individuals who underwent cholecystectomy have an increased risk of fractures, especially vertebral and hip fractures. The risk of vertebral fractures following cholecystectomy is more prominent in the younger population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Guo Tang, Long Feng, Yu Pei, Zhaoyan Gu, Tingting Chen, Zeguo Feng
Summary: This study aimed to explore the risk factors of osteoporosis in postmenopausal women in China. The results showed that low BMI, blood calcium and vitamin D levels, kyphosis time, and outdoor activity time were independent risk factors for osteoporosis in postmenopausal women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Betsy Szeto, Chris Valentini, Anil K. Lalwani
Summary: This study found that low vitamin D status was associated with low-frequency and speech-frequency HL in the elderly, while serum PTH and total calcium were not associated with HL.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Medicine, General & Internal
Song-Li Pan, Chen-Cui Li, Hong-Wang Cui, Wen-Xian Wang, Chun-Hong Li
Summary: This study aims to evaluate the efficiency of calcium and vitamin D in treating adults diagnosed with osteoporosis caused by corticosteroid therapy. Through systematic literature search and quality assessment, this study will provide additional evidence and practical information for clinicians and policymakers.
Article
Nutrition & Dietetics
Mengjie Yuan, Frank B. Hu, Yanping Li, Howard J. Cabral, Sai Krupa Das, Jude T. Deeney, Xinyi Zhou, Julie M. Paik, Lynn L. Moore
Summary: The study found that higher intake of total dairy, milk, and cheese is associated with lower risks of fracture in females, while yogurt intake is not associated with fracture risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Keren E. Dittmer, Anastasia Chernyavtseva, Jonathan C. Marshall, Diana Cabrera, Frances M. Wolber, Marlena Kruger
Summary: Osteoporosis is a global public health issue, with approximately 3/4 of cases resulting from estrogen deficiency after menopause. This study used sheep as a model for osteoporosis and conducted experiments by performing ovariectomy and administering glucocorticoids. The results demonstrated that the expression of the klotho gene in the kidney showed the most significant difference in ovariectomized sheep treated with glucocorticoids for 2 months followed by a recovery period of 3 months. Klotho, known as the anti-aging hormone, is involved in the regulation of calcium and phosphorus metabolism, and it may play an important role in the recovery of bone mineral density in ovariectomized sheep treated with glucocorticoids for 2 months followed by euthanasia at 5 months.
Article
Nutrition & Dietetics
Sousana K. Papadopoulou, Konstantinos Papadimitriou, Gavriela Voulgaridou, Evridiki Georgaki, Eudoxia Tsotidou, Olga Zantidou, Dimitrios Papandreou
Summary: Non-pharmaceutical approaches such as exercise and nutrition play important roles in preventing osteoporosis and sarcopenia in older adults; most studies show that resistance and endurance exercises can prevent these bone diseases, while protein and vitamin D intake are beneficial; however, current scientific data are insufficient for reaching definitive conclusions.
Article
Endocrinology & Metabolism
Enrique Soto-Pedre, Yeun Yi Lin, Jimena Soto-Hernaez, Paul J. Newey, Graham P. Leese
Summary: This study aimed to assess morbidity and mortality associated with primary hyperparathyroidism (PHPT). A large population-based retrospective study found that patients with PHPT had increased risk of death and various clinical diseases, including cardiovascular disease, cerebrovascular disease, diabetes, renal stones, and osteoporosis. These risks were independent of serum vitamin D concentration.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Orthopedics
Fei Feng, Guan Shi, Hao Chen, Pu Jia, Li Bao, Feng Xu, Qin-chao Sun, Hai Tang
Summary: The study results suggest that active vitamin D is more effective than non-active vitamin D in improving physical ability and lumbar vertebral bone mineral density in elderly patients, reducing the risk of falls.
ORTHOPAEDIC SURGERY
(2021)
Review
Immunology
Kavin Khatri, Manmeet Kaur, Tanish Dhir, Ankita Kankaria, Hobinder Arora
Summary: This meta-analysis study evaluated the effect of calcium, vitamin D, or a combination of the two on the risk of fractures in elderly population compared to no treatment or placebo. The results showed that the routine administration of calcium and vitamin D did not lower the risk of fractures in elderly population.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Aleksey Bychkov, Vyacheslav Koptev, Varvara Zaharova, Polina Reshetnikova, Elena Trofimova, Elena Bychkova, Ekaterina Podgorbunskikh, Oleg Lomovsky
Summary: This study presents findings on the biological action of a supplement containing vitamin D and soluble silicon, which are involved in bone formation and mineralization. The supplement showed the ability to stimulate bone tissue regeneration, accelerate bone cell differentiation, and promote the restoration of bone structure. Additionally, it enhanced calcium absorption and reduced skeletal damage.
Article
Nutrition & Dietetics
Jakub Erdmann, Michal Wicinski, Pawel Szyperski, Sandra Gajewska, Jakub Ohla, Maciej Slupski
Summary: Vitamin D helps balance calcium and phosphorus levels for proper bone structure and has a variety of potential benefits. The authors investigated its preventive effects on vertebral fractures, hip fractures, stress fractures, and pediatric fractures, as well as its impact on recovery and severity of fractures. Vitamin D supplementation may reduce hip fracture risk through decreased bone turnover, fewer falls, and improved muscle function. It also appears to lower stress fracture risk in athletes and military recruits. However, inconsistencies were found in the relationship between vitamin D supplementation and reduced vertebral fracture risk. The preventive effect of vitamin D on pediatric fractures seems unlikely.
Article
Rheumatology
James M. Gwinnutt, Maud Wieczorek, Andra Balanescu, Heike A. Bischoff-Ferrari, Annelies Boonen, Giulio Cavalli, Savia de Souza, Annette de Thurah, Thomas E. Dorner, Rikke Helene Moe, Polina Putrik, Javier Rodriguez-Carrio, Lucia Silva-Fernandez, Tanja Stamm, Karen Walker-Bone, Joep Welling, Mirjana Zlatkovic-Svenda, Francis Guillemin, Suzanne M. M. Verstappen
Summary: A taskforce in Europe has reviewed the literature and developed recommendations on lifestyle behaviors for rheumatic and musculoskeletal diseases. They have identified five overarching principles and 18 specific recommendations based on available evidence. The recommendations cover various lifestyle factors such as exercise, diet, weight, alcohol, smoking, and work participation.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Geriatrics & Gerontology
Virginia Ghisla, Patricia O. Chocano-Bedoya, Endel John Orav, Lauren A. Abderhalden, Angelique Sadlon, Andreas Egli, Jan Kruetzfeldt, John A. Kanis, Heike A. Bischoff-Ferrari
Summary: This study evaluated the prevalence and prospective change of health states among European older adults, and found that the likelihood of transitioning to a healthier state decreased with advancing age and among women.
Article
Medicine, General & Internal
Caroline de Godoi Rezende Costa Molino, Patricia O. Chocano-Bedoya, Angelique Sadlon, Robert Theiler, John E. Orav, Bruno Vellas, Rene Rizzoli, Reto W. Kressig, John A. Kanis, Sophie Guyonnet, Wei Lang, Andreas Egli, Heike A. Bischoff-Ferrari
Summary: Polypharmacy is common among relatively healthy older adults in seven European cities, with moderate variability. Being a woman, older age, greater BMI, and more comorbidities are associated with increased odds for polypharmacy. Living situation, smoking status, years of education, prior fall, cognitive function, self-rated health, and frailty status are not significantly associated with polypharmacy.
Article
Geriatrics & Gerontology
Simeon Schietzel, Patricia O. Chocano-Bedoya, Angelique Sadlon, Michael Gagesch, Walter C. Willett, Endel J. Orav, Reto W. Kressig, Bruno Vellas, Rene Rizzoli, Jose A. P. da Silva, Michael Blauth, John A. Kanis, Andreas Egli, Heike A. Bischoff-Ferrari
Summary: This study compared the prevalence of healthy aging among adults age 70 and older from 5 European countries. The results showed significant variability in healthy aging prevalence among different countries, with the highest prevalence in participants from Austria and Switzerland and the lowest prevalence in participants from Portugal. Independent of country, younger age, female gender, lower BMI, and better physical function were associated with healthy aging.
Article
Nutrition & Dietetics
Caroline de Godoi Rezende Costa Molino, Laurence Woll, Maud Wieczorek, Lauren A. Abderhalden, Patricia Lanz, Dominik J. Schaer, Donat R. Spahn, E. John Orav, Andreas Egli, Heike A. Bischoff-Ferrari
Summary: This study found that iron deficiency is associated with an increased number of hospitalizations in older adults, but not with the length of hospital stay. Iron deficiency is a factor in the health of older adults and efforts should be made to reduce iron deficiency to improve overall health outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Lisa Ceglia, Donato A. Rivas, Mathias Schloegl, Grace B. Fielding, Andreas Egli, Heike A. Bischoff-Ferrari, Bess Dawson-Hughes
Summary: This study compared the effect of different forms of vitamin D on intramyonuclear vitamin D receptor concentration, muscle fiber cross-sectional area, and muscle satellite cell activation. The results showed that although calcifediol resulted in the highest serum 25-hydroxyvitamin D levels, no skeletal muscle benefits were observed at these high levels.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Geriatrics & Gerontology
Sarah Huberty, Gregor Freystatter, Maud Wieczorek, Bess Dawson-Hughes, John A. Kanis, Rene Rizzoli, Reto W. Kressig, Bruno Vellas, Jose A. P. Da Silva, Gabriele Armbrecht, Robert Theiler, Andreas Egli, Endel J. Orav, Heike A. Bischoff-Ferrari
Summary: This study investigated the association between the baseline number of chronic diseases and multimorbidity, and the incidence of all and injurious falls over 3 years among European community-dwelling older adults. The results showed that both the presence of chronic diseases and multimorbidity were associated with an increased incidence of falls, even in generally healthy and active older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Endocrinology & Metabolism
Isabelle Hoffmann, Matthias Kohl, Simon von Stengel, Franz Jakob, Katharina Kerschan-Schindl, Uwe Lange, Stefan Peters, Daniel Schoene, Cornel Sieber, Friederike Thomasius, Heike A. Bischoff-Ferrari, Michael Uder, Wolfgang Kemmler
Summary: This study provides positive evidence for the effects of exercise on the number of osteoporotic fractures in adults, although there is no significant relevance found between intensity progression or study duration. However, there is still uncertainty in identifying the most effective exercise protocol for reducing fractures.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Rheumatology
Maud Wieczorek, Suzanne MM. Verstappen, Polina Putrik, James M. Gwinnutt, Andra Balanescu, Heike A. Bischoff-Ferrari, Annelies Boonen, Giulio Cavalli, Savia de Souza, Annette de Thurah, Thomas E. Dorner, Rikke Helene Moe, Javier Rodriguez-Carrio, Lucia Silva-Fernandezu, Tanja Stamm, Karen Walker-Bone, Joep Welling, Mirjana Zlatkovic-Svenda, Francis Guillemin
Summary: This paper reviews the impact of work-related factors on disease-specific outcomes for individuals with rheumatic and musculoskeletal diseases. The findings suggest that work participation may be beneficial for RMD-specific outcomes and should be addressed in healthcare consultations.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Geriatrics & Gerontology
Anna K. K. Stuck, Giacomo Basile, Gregor Freystaetter, Caroline de Godoi Rezende Costa Molino, Wei Lang, Heike A. A. Bischoff-Ferrari
Summary: In the past 3 years, new definitions of sarcopenia have been proposed by the SARCOPENIA Definition and Outcome Consortium, European Working Group on Sarcopenia in Older People, and Asian Working Group on Sarcopenia. This scoping review aimed to explore the predictive validity of these definitions for clinical outcomes. The results showed limited studies on the predictive validity of these definitions and a lack of data for the SDOC and AWGS2 definitions.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Michael Gagesch, Andreas Huni, Heike Geschwindner, Lauren A. Abderhalden, Wei Lang, Gaby Bieri-Bruning, Heike A. Bischoff-Ferrari
Summary: This study investigated the feasibility of a 12-month follow-up after post-acute care (PAC) in Swiss nursing homes and examined factors influencing participation rate. The overall mortality at 12 months was 25%, with 25% participating in the follow-up, and 50% declining participation. Participants had significantly higher Mini-Mental State Examination (MMSE) scores compared to non-participants, and higher cognitive function was associated with a greater willingness to participate.
Article
Pharmacology & Pharmacy
Caroline de Godoi Rezende Costa Molino, Lisa Rubel, Noemi Mantegazza, Heike A. Bischoff-Ferrari, Gregor Freystaetter
Summary: This study examined the association between polypharmacy and cognitive impairment in trauma patients aged 70 years and older. The results showed that polypharmacy was not significantly associated with cognitive impairment, but excessive polypharmacy and the number of medications were associated with a higher risk of cognitive impairment in older trauma patients.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Endocrinology & Metabolism
J. A. Kanis, H. Johansson, E. McCloskey, E. Liu, K. E. Akesson, F. A. Anderson, R. Azagra, C. L. Bager, C. Beaudart, H. A. Bischoff-Ferrari, E. Biver, O. Bruyere, J. A. Cauley, J. R. Center, R. Chapurlat, C. Christiansen, C. Cooper, C. J. Crandall, S. R. Cummings, J. A. P. da Silva, B. Dawson-Hughes, A. Diez-Perez, A. B. Dufour, J. A. Eisman, P. J. M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C. -c. Glueer, I. Goldshtein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, R. J. Hollick, M. Huisman, M. Iki, S. Ish-Shalom, G. Jones, M. K. Karlsson, S. Khosla, D. P. Kiel, W. -p. Koh, F. Koromani, M. A. Kotowicz, H. Kroger, T. Kwok, O. Lamy, A. Langhammer, B. Larijani, K. Lippuner, D. Mellstrom, T. Merlijn, A. Nordstrom, P. Nordstrom, T. W. O'Neill, B. Obermayer-Pietsch, C. Ohlsson, E. S. Orwoll, J. A. Pasco, F. Rivadeneira, A. -M. Schott, E. J. Shiroma, K. Siggeirsdottir, E. M. Simonsick, E. Sornay-Rendu, R. Sund, K. M. A. Swart, P. Szulc, J. Tamaki, D. J. Torgerson, N. M. van Schoor, T. P. van Staa, J. Vila, N. J. Wareham, N. C. Wright, N. Yoshimura, M. C. Zillikens, M. Zwart, L. Vandenput, N. C. Harvey, M. Lorentzon, W. D. Leslie
Summary: A large international meta-analysis finds that a previous history of fracture is associated with an increased risk of future fractures, regardless of age, sex, and bone mineral density. The study highlights the importance of considering previous fracture history as a risk factor for fracture prevention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Heike A. Bischoff-Ferrari, Sirka Nitschmann
Article
Geriatrics & Gerontology
Michael Gagesch, M. Wieczorek, B. Vellas, R. W. Kressig, R. Rizzoli, J. Kanis, W. C. Willett, A. Egli, W. Lang, E. J. Orav, H. A. Bischoff-Ferrari
Summary: Robust, generally healthy and active older adults without major comorbidities may benefit from a combination of high-dose supplemental vitamin D3, marine omega-3s, and a simple home exercise program (SHEP) with regard to the risk of becoming pre-frail over 3 years.
JOURNAL OF FRAILTY & AGING
(2023)