Article
Engineering, Chemical
Chao-Ling Yao, Li-Cheng Lu, Wei-Chun Weng, Chien-Hsun Huang, Tsung-Yu Tseng
Summary: The study aimed to develop a serum-free medium for the induction of monocyte-derived dendritic cells (DCs). The results showed that serum-free induced DCs expressed DC-related surface markers and exhibited endocytosis ability. Moreover, serum-free induced DCs secreted higher amounts of cytokines and showed a better ability to stimulate T cell proliferation compared to DCs cultured in serum-containing medium.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Immunology
Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Soren Brunak, Anders Woetmann, Niels odum, Charlotte M. Bonefeld, Carsten Geisler
Summary: This study reveals the impact of a point mutation in the DNA-binding domain of VDR on 1,25(OH)(2)D-3 signaling, with effects on VDR subcellular localization and transcriptional activity. The study also demonstrates that the expression level of wild-type VDR determines the responsiveness of T cells to 1,25(OH)(2)D-3. Additionally, the study shows that vitamin A inhibits the translocation of VDR to the nucleus and upregulation of CYP24A1 induced by 1,25(OH)(2)D-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Caroline Severo de Assis, Taina Gomes Diniz, Joao Otavio Scarano Alcantara, Vanessa Polyana Alves de Sousa Brito, Rayner Anderson Ferreira do Nascimento, Mayara Karla dos Santos Nunes, Alexandre Sergio Silva, Isabella Wanderley de Queiroga Evangelista, Marina Goncalves Monteiro Viturino, Rafaela Lira Formiga Cavalcanti de Lima, Darlene Camati Persuhn
Summary: This study aimed to investigate the association between Bsml and DM2 in patients with and without DR, and to identify associated clinical parameters. The findings revealed that DR patients had a higher frequency of insulin therapy and longer duration of DM2, in addition to higher serum creatinine levels. Patients with DR and b allele carriers also had higher fasting glucose levels and insulin therapy frequency compared to BB carriers.
Article
Biochemistry & Molecular Biology
Nabab Khan, Peter W. Halcrow, Zahra Afghah, Aparajita Baral, Jonathan D. Geiger, Xuesong Chen
Summary: The accumulation of HIV-1 Tat in endolysosomes may play an important role in controlling HIV-1 transactivation, further hindering the cure of HIV-1.
Article
Multidisciplinary Sciences
Ayad Naji Radha Al-Gharrawi, Enayat Anvari, Abolfazl Fateh
Summary: A growing body of research has shown the importance of vitamin D in the prognosis of COVID-19. This study aimed to evaluate the association between ApaI rs7975232 and BsmI rs1544410 polymorphisms in different SARS-CoV-2 variants and the outcomes of COVID-19. The findings revealed that certain genotypes of these polymorphisms were associated with higher mortality rates in specific variants.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yeganeh Mehrani, Solmaz Morovati, Sophie Tieu, Negar Karimi, Helia Javadi, Sierra Vanderkamp, Soroush Sarmadi, Tahmineh Tajik, Julia E. Kakish, Byram W. Bridle, Khalil Karimi
Summary: Mast cells (MCs) play a crucial role in immune defense, not only against parasites but also in response to viral, bacterial, and fungal infections. Vitamin D, as an important immunomodulatory factor, regulates immune homeostasis and stabilizes MCs, thus enhancing pathogen clearance.
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Article
Biochemistry & Molecular Biology
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Summary: Vitamin D and VDR play critical roles in maintaining calcium homeostasis, bone formation, and immune response against cancer. Mutations in the VDR gene are associated with manifestations of type II rickets and abnormal bone formation. The unliganded VDR is crucial for maintaining the hair cycle and normal skin.
Article
Biochemistry & Molecular Biology
Kazuki Maekawa, Michiyasu Ishizawa, Takashi Ikawa, Hironao Sajiki, Taro Matsumoto, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada
Summary: The active form of vitamin D-3, 1,25-dihydroxyvitamin D-3, regulates calcium homeostasis through activation of the vitamin D receptor (VDR). Vitamin D derivatives with large adamantane (AD) rings at certain positions of the side chain were synthesized to study their VDR agonist and/or antagonist properties. Novel vitamin D derivatives with an alkyl group substituted at position 25 showed selective VDR activity and enhanced osteoblast differentiation compared to the original derivative, ADTK1. These modified derivatives have the potential for targeted therapy with increased stability and tissue selectivity.
Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Immunology
Jean-Charles Guery
Summary: Plasmacytoid dendritic cells (pDCs) in women produce higher levels of TLR7-driven type I interferon during HIV-1 infection, leading to stronger antiviral responses compared to men. However, excessive TLR7 response in women has been found to have a deleterious impact on acute viremia. This is attributed to specific genetic variations in TLR7 which affect protein synthesis and effector function, resulting in lower viral load during primary HIV-1 infection in females.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Valentina Aristarco, Harriet Johansson, Sara Gandini, Debora Macis, Cristina Zanzottera, Gianluca Tolva, Irene Feroce, Chiara Accornero, Bernardo Bonanni, Aliana Guerrieri-Gonzaga, Davide Serrano
Summary: This study found that SNPs of VDR and GC genes may influence breast cancer recurrence and survival in patients, particularly with major alleles of BsmI and TaqI showing lower risk of relapse.
Article
Virology
Riley M. Horvath, Zabrina L. Brumme, Ivan Sadowski
Summary: Mediator kinases CDK8 and CDK19 play a significant role in regulating HIV-1 transcription, and inhibitors of these enzymes may contribute to therapies for latent HIV-1 infection.
JOURNAL OF VIROLOGY
(2023)
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
R. D. Acemel, J. J. Tena, J. L. Gomez-Skarmeta, J. Fibla, J. L. Royo
Summary: A key advance in understanding gene regulation is the discovery of three-dimensional nuclear folding in the genome, influencing enhancer-promoter interactions. New technologies quantifying these DNA interactions have revolutionized the field, but may lack resolution for subtle effects of single nucleotide polymorphisms. The impact of a common deletion between the SIRPB1 promoter and one of its downstream enhancers was analyzed as proof of concept for a cost-efficient allele-specific chromatin conformation analysis approach.
Article
Infectious Diseases
Rosa Maria Vivanco-Hidalgo, Israel Molina, Elisenda Martinez, Ramon Roman-Vinas, Adrian Sanchez-Montalva, Joan Fibla, Caridad Pontes, Cesar Velasco Munoz
Summary: The study found that patients chronically exposed to chloroquine/hydroxychloroquine did not differ in risk of COVID-19 or hospitalization compared with controls. Although the exposed cohort appeared to have a higher hospitalization rate, this difference was not confirmed after adjustment.
Article
Oncology
Abdelnaby Khalyfa, Wojciech Trzepizur, Alex Gileles-Hillel, Zhuanhong Qiao, David Sanz-Rubio, Jose M. Marin, Miguel A. Martinez-Garcia, Francisco Campos-Rodriguez, Isaac Almendros, Ramon Farre, Manuel Sanchez-de-la-Torre, Francisco Garcia-Rio, David Gozal
Summary: The study showed that untreated OSA patients' plasma exosomes can increase the proliferation and migration of CRL-1424 melanoma cells, but not in the other two cell lines. After exposure to IH, melanoma cells exhibited different exosomal miRNA profiles, indicating differential susceptibility to IH and similar effects on immune cell polarity. Mutations in the STK11 gene may play a role in susceptibility to IH-induced metabolic dysfunction in melanoma cells.
Article
Cell Biology
Carmen Serrano-Risquez, Mohamed Omar, Maria Amparo Gomez-Vidal, Luis Miguel Real, Juan Antonio Pineda, Antonio Rivero, Antonio Rivero-Juarez, Donald Forthal, Francisco J. Marquez, Sergio Lo Caputo, Mario Clerici, Mara Biasin, Antonio Caruz
Summary: CD46 gene variants are associated with susceptibility to various infectious and autoimmune diseases, with HIV-1 being able to exploit CD46 function to evade complement attack. In a study involving individuals of European ancestry, a specific CD46 genetic variant was found to be associated with increased resistance to HIV-1 infection, with this protective genotype showing alterations in CD46 expression and mRNA splicing isoforms.
Article
Microbiology
Leonardo Sorrentino, Valentina Silvestri, Giuseppe Oliveto, Mirko Scordio, Federica Frasca, Matteo Fracella, Camilla Bitossi, Alessandra D'Auria, Letizia Santinelli, Lucia Gabriele, Alessandra Pierangeli, Claudio Maria Mastroianni, Gabriella d'Ettorre, Guido Antonelli, Antonio Caruz, Laura Ottini, Carolina Scagnolari
Summary: Type III interferons (IFN-III), also known as IFN-Lambda, play a pivotal role in SARS-CoV-2 infection. The distribution of IFNL4 SNP in COVID-19 patients is comparable to healthy controls. However, different genotypes of IFNL4 are associated with variations in white blood cells and neutrophils counts among COVID-19 patients.
Article
Immunology
Giovanna Meza, Fatima Galian, Claudia Jaimes-Bernal, Francisco J. Marquez, Faruk Sinangil, Carolina Scagnolari, Luis Miguel Real, Donald Forthal, Antonio Caruz
Summary: This study confirmed the association between the null allele of IFNL4 and HIV-1 susceptibility in a cohort of men who have sex with men. The null IFNL4 genotypes were correlated with lower HIV-1 seroconversion risk and longer time to seroconversion. A meta-analysis also supported this association.
Article
Medicine, General & Internal
Andrea Zapater, Geoffroy Solelhac, Alicia Sanchez-de-la-Torre, Esther Gracia-Lavedan, Ivan David Benitez, Gerard Torres, Jordi De Batlle, Jose Haba-Rubio, Mathieu Berger, Jorge Abad, Joaquin Duran-Cantolla, Amaia Urrutia, Olga Mediano, Maria Jose Masdeu, Estrella Ordax-Carbajo, Juan Fernando Masa, Monica De la Pena, Merce Mayos, Ramon Coloma, Josep Maria Montserrat, Eusebi Chiner, Olga Minguez, Lydia Pascual, Anunciacion Cortijo, Dolores Martinez, Mireia Dalmases, Chi-Hang Lee, R. Doug McEvoy, Ferran Barbe, Raphael Heinzer, Manuel Sanchez-de-la-Torre, Spanish Sleep Network
Summary: The severity of OSA is assessed based on the AHI, which is insufficient for capturing the severity and consequences of the disease in CVDs. This study aimed to identify RP patterns that could help in predicting the risk of recurrent cardiovascular events in patients with ACS. The analysis revealed that specific RP components, characterized by different respiratory events, were associated with an increased risk of recurrent cardiovascular events in ACS patients.
FRONTIERS IN MEDICINE
(2022)
Article
Respiratory System
Miguel A. Martinez-Garcia, Manuel Sanchez-de-la-Torre, David P. White, Ali Azarbarzin
Summary: Conventional measures of OSA severity, such as AHI and ODI, have limitations in capturing the severity of OSA and its physiological consequences. The sleep apnea-specific hypoxic burden (HB), which measures the sum of individual areas under the oxygen desaturation curve, shows promise in identifying high-risk individuals with OSA. HB captures the depth and duration of OSA-related hypoxemia, providing important disease characterizing features not captured by conventional metrics.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Editorial Material
Clinical Neurology
Adriano D. S. Targa, Manuel Sanchez-de-la-Torre
SLEEP MEDICINE REVIEWS
(2023)
Letter
Critical Care Medicine
Geoffroy Solelhac, Manuel Sanchez-de-la-Torre, Margaux Blanchard, Ferran Barbe, Frederic Gagnadoux, Raphael Heinzer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Geoffroy Solelhac, Manuel Sanchez-de-la-Torre, Margaux Blanchard, Mathieu Berger, Camila Hirotsu, Theo Imler, Alicia Sanchez-de-la-Torre, Jose Haba-Rubio, Nicola Andrea Marchi, Virginie Bayon, Sebastien Bailly, Francois Goupil, Adrien Waeber, Gregory Heiniger, Thierry Pigeanne, Esther Gracia-Lavedan, Andrea Zapater, Jorge Abad, Estrella Ordax, Maria Jose Masdeu, Valentin Cabriada-Nuno, Carlos Egea, Sandra Van Den Broecke, Peter Vollenweider, Pedro Marques-Vidal, Julien Vaucher, Giulio Bernardi, Monica Betta, Francesca Siclari, Ferran Barbe, Frederic Gagnadoux, Raphael Heinzer
Summary: This study investigated the value of pulse wave amplitude drops (PWADs) as a biomarker of cardiovascular risk in patients with obstructive sleep apnea (OSA). The results showed that patients with a low PWAD index and OSA had a higher incidence of cardiovascular events compared to other groups.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Manuel Sanchez-de-la-Torre, Esther Gracia-Lavedan, Ivan David Benitez, Andrea Zapater, Gerard Torres, Alicia Sanchez-de-la-Torre, Albina Aldoma, Jordi de Batlle, Adriano Targa, Jorge Abad, Joaquin Duran-Cantolla, Amaia Urrutia, Olga Mediano, Maria Jose Masdeu, Estrella Ordax-Carbajo, Juan Fernando Masa, Monica De la Pena, Merce Mayos, Ramon Coloma, Josep Maria Montserrat, Eusebi Chiner, Olga Minguez, Lydia Pascual, Anunciacion Cortijo, Dolores Martinez, Mireia Dalmases, Chi-Hang Lee, R. Doug McEvoy, Ferran Barbe
Summary: This study investigates the association between severe obstructive sleep apnea (OSA) and long-term blood pressure increase in patients with acute coronary syndrome (ACS), as well as the impact of continuous positive airway pressure (CPAP) adherence on blood pressure.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Meeting Abstract
Critical Care Medicine
M. Sanchez De La Torre, E. Garcia Gil, I. Benitez, A. Zapater, G. Torres, A. Sanchez-de-la-Torre, J. De Batlle, A. Targa, O. Minguez, L. Pascual, A. Cortijo Fernandez, D. Martinez, M. Dalmases, F. Barbe
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Emer M. Van Ryswyk, Ivan D. Benitez, Alexander M. Sweetman, Nuria Nadal, Ching Li Chai-Coetzer, Juan Fernando Masa, Francisco Javier Gomez de Terreros, Robert J. Adams, Manuel Sanchez-de-la-Torre, Nigel Stocks, Billingsley Kaambwa, R. Doug McEvoy, Ferran Barbe
Summary: This study compared the outcomes and cost-effectiveness of sleep apnea management in primary care versus specialist care. The findings showed that primary care-based management of sleep apnea had similar outcomes at a lower cost, providing strong support for its implementation.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Jordi de Batlle, Sandra Bertran, Cecilia Turino, Joan Escarrabill, Mireia Dalmases, Anna Garcia-Altes, Esther Sapina-Beltran, Elisenda Martinez Carbonell, Manuel Sanchez-de-la-Torre, Ferran Barbe
Summary: A population-based longitudinal observational study in Catalonia, Spain found that patients treated with CPAP had a lower mortality rate compared to control subjects, primarily driven by cancer-related deaths. There was an increased risk of respiratory-related death in CPAP-treated women. This suggests a potential role for sex in CPAP prescription and raises questions about the relationship between OSA and cardiovascular outcomes.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
