Article
Endocrinology & Metabolism
Yun Jeong Lee, Yeon Jin Cho, You Joung Heo, Eun-Jae Chung, Young Hun Choi, Jong-Il Kim, Young Joo Park, Choong Ho Shin, Young Ah Lee
Summary: In youth with childhood-onset Hashimoto thyroiditis (HT) in an iodine-sufficient country, the detection rate of thyroid nodules was 18.8%, with a 22.5% risk of malignancy among the detected nodules, showing increased risk in those with a family history. Additional large-scale studies are required to evaluate the usefulness of K-TIRADS or ACR-TI-RADS risk level for the differentiation of paediatric thyroid nodules.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Mengyuan Fang, Mengjie Lei, Xuexue Chen, Hong Cao, Xingxing Duan, Hongxia Yuan, Lili Guo
Summary: This study analyzed the clinical and ultrasound radiomics features of thyroid nodules in patients with Hashimoto's thyroiditis and constructed a model for differentiating between benign and malignant nodules in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiangyue Xu, Ke Ding, Lan Mu, Jiangsheng Huang, Fei Ye, Yu Peng, Can Guo, Chutong Ren
Summary: This study found that Hashimoto's thyroiditis (HT) is associated with thyroid carcinoma (TC), where HT is a risk factor for TC and papillary thyroid carcinoma (PTC), but acts as a protective factor against PTC progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Natalia Zeber-Lubecka, Ewa E. Hennig
Summary: PCOS and HT are common endocrine disorders, with a higher prevalence of HT observed in women with PCOS. The simultaneous occurrence of both diseases is associated with a higher risk of severe metabolic and reproductive complications. Genetic factors strongly impact the pathogenesis of both PCOS and HT, with several susceptibility loci identified.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peter P. Issa, Mahmoud Omar, Yusef Buti, Chad P. Issa, Bert Chabot, Christopher J. Carnabatu, Ruhul Munshi, Mohammad Hussein, Mohamed Aboueisha, Mohamed Shama, Ralph L. Corsetti, Eman Toraih, Emad Kandil
Summary: This study analyzed the influence of Hashimoto's thyroiditis (HT) on patients with papillary thyroid cancer (PTC) and its effect on lymph node metastasis (LNM) in BRAF mutant tumors. The results showed that HT reduces the risk of LNM in PTC patients, especially for those with BRAF mutation. This research has important implications for treatment decisions by endocrinologists, oncologists, and surgeons.
Article
Oncology
Xiao-xiong Gan, Ya-yi Li, Si-jin Li, Shi-sen Mo, Jian-hua Feng, Fei Shen, Wen-song Cai, Ye-qian Lai, Bo Xu
Summary: Papillary thyroid carcinoma (PTC) concurrent with Hashimoto's thyroiditis (HT) is associated with better clinical prognosis. DMBT1 may act as a potential factor inhibiting tumors, and its high expression could improve PTC prognosis through immune-related pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Timm Amendt, Hassan Jumaa
Summary: The study indicates that autoreactive antibodies can be easily generated in wild-type animals, but adaptive tolerance can prevent autoimmune diseases by inducing affinity-matured IgM specific to self-antigens. This suggests that B-cell tolerance does not necessarily involve the complete elimination of autoreactive specificities, as inducible generation of autoantigen-specific high-affinity IgM serves as a protective mechanism against self-destruction.
Article
Oncology
Jean-Nicolas Gallant, Vivian L. Weiss, Sheau-Chiann Chen, Jiancong Liang, Ryan H. Belcher, Fei Ye, Hernan Correa, Huiying Wang
Summary: This study found an association between pediatric thyroid cancer and HT, although this association does not seem to affect patient outcomes or survival.
Article
Medicine, General & Internal
Genpeng Li, Linye He, Jing Huang, Jiaye Liu, Wenjie Chen, Jinjing Zhong, Tao Wei, Zhihui Li, Jingqiang Zhu, Jianyong Lei
Summary: This study investigated the role and mechanisms of tissue small extracellular vesicle (sEV) microRNAs in Hashimoto's thyroiditis (HT). It was found that miR-142-3p encapsulated in T lymphocyte-derived sEVs contributes to Treg function defect and thyrocyte destruction by blocking the activation of the ERK1/2 signaling pathway. These findings highlight the importance of tissue sEV-mediated miR-142-3p transfer in the progression of HT.
Article
Oncology
Peter P. Issa, Mahmoud Omar, Yusef Buti, Mohamed Aboueisha, Ruhul Munshi, Mohammad Hussein, Muhib Haidari, Graham Blair, Chad P. Issa, Mohamed Shama, Eman Toraih, Emad Kandil
Summary: Hashimoto's thyroiditis is a protective factor against recurrence in patients with BRAF-wild type thyroid carcinoma, while BRAF-mutation is a risk factor for thyroid cancer aggressiveness. The presence of Hashimoto's thyroiditis reduces the risk of lymph node metastasis in BRAF-mutated papillary thyroid carcinoma, but its effect on disease recurrence in differentiated thyroid carcinoma (DTC) is unclear.
Article
Immunology
Tianyu Zhang, Feifei Hou, Dan Liu, Hangfan Zhou, Yutong Sun, Xiaoting Deng, Yiming Xu, Yanxuan Xiao, Xianwen Wang, Chuanji Wu, Yang Meng, Peiyang Yuan, Xuemei Qiu, Lu Ye, Yuye Liang, Wei Wei, Lu Jiang
Summary: This study found that the prevalence of Hashimoto's thyroiditis was higher in patients with oral lichen planus, especially in females. Female patients also had higher levels of auto-anti-thyroid antibodies. However, the clinical manifestations of oral lichen planus were not significantly correlated with the development of Hashimoto's thyroiditis or auto-anti-thyroid antibody levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yiqing Hou, Chao Chen, Lu Zhang, Wei Zhou, Qinyang Lu, Xiaohong Jia, Jingwen Zhang, Cen Guo, Yuxiang Qin, Lifeng Zhu, Ming Zuo, Jing Xiao, Lingyun Huang, Weiwei Zhan
Summary: This study successfully developed an efficient method for diagnosing thyroid nodules using a Deep Neural Network model, demonstrating good performance under various parenchymal conditions and especially showing superior performance in patients with Hashimoto's Thyroiditis compared to radiologists with different years of experience.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Ting-ting Liu, De-tao Yin, Nan Wang, Na Li, Gang Dong, Meng-fan Peng
Summary: This study aimed to identify key genes shared by Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) in order to advance the understanding of their shared pathogenesis and molecular mechanisms. Through analysis of gene expression databases, several shared genes related to HT and PTC were identified, and four of them were determined to be key genes. Further experimental validation confirmed the diagnostic potential of these key genes, which could improve patient diagnosis and prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Andrzej Hellmann, Jacek Turyn, Agata Zwara, Justyna Korczynska, Aleksandra Taciak, Adriana Mika
Summary: The study aims to analyze amino acid metabolites in the serum of patients with papillary thyroid carcinoma (PTC) and predict their association with thyroid disease, hormone, and autoantibodies. The results showed that amino acid changes are specific for autoimmune disorders and thyroid cancer. Glutamic acid and lysine can be used as diagnostic markers to distinguish different types of PTC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tina Mosaferi, Karen Tsai, Samantha Sovich, Holly Wilhalme, Nikhita Kathuria-Prakash, Stephanie S. Praw, Alexandra Drakaki, Trevor E. Angell, Melissa G. Lechner
Summary: Patients with ICI-associated hypothyroidism have different thyroid hormone dosing requirements than patients with HT. Based on our findings and prior reports, we recommend that in patients with ICI-associated thyroiditis LT4 therapy be started at an initial weight-based dose of 1.45 mcg/[kg center dot day] once serum free thyroxine levels fall below the reference range.