Article
Pharmacology & Pharmacy
Zhenyu Li, Huasong Shi, Yanmei Li, Wang Wang, Zhexi Li, Biao Chen, Daibang Nie
Summary: This study discovered that isorhynchophylline (IRN) has protective effects on human osteoarthritis (OA) chondrocytes. The protective effects of IRN may be attributed to its inhibition of the NF-kappa B pathway, which leads to a reduction in inflammatory and degenerative progression of OA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Qing Ding, Ruizhuo Zhang, Gaohong Sheng, Tianqi Wang, Shaoze Jing, Tian Ma, Shanxi Wang, Hongqi Zhao, Hua Wu, Wenkai Li
Summary: Osteoarthritis (OA) is a common joint disease that causes physical disability in the elderly. Dioscin, a natural plant extract, has shown promise in treating OA due to its anti-inflammatory effects and ability to improve chondrocyte matrix homeostasis. This study found that Dioscin inhibited inflammatory cytokines and matrix metalloproteinases in OA, and improved collagen synthesis. It also reduced pain behaviors and cartilage erosion in rat models. These results suggest that Dioscin could be a promising therapeutic agent for OA.
JOURNAL OF INFLAMMATION-LONDON
(2023)
Article
Immunology
Zhuang Qian, Xin Gao, Xinxin Jin, Xiaomin Kang, Shufang Wu
Summary: The study found that Bmal1 plays an important role in cartilage development and homeostasis. However, its contribution to osteoarthritis (OA) progression is still unclear. This study used cartilage-specific knockout mice to investigate the role of Bmal1 in OA progression. The results showed that the loss of Bmal1 accelerated cartilage degradation and chondrocyte apoptosis, leading to OA progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meisong Zhu, Zhiyou Cao, Fengbo Mo, Shoujie Shi, Jiawei Hu, Qiang Xu, Kun Quan, Wei Li, Jianhui Liang, Xin Hong, Bin Zhang, Xuqiang Liu, Min Dai
Summary: This study found that ADRM1 plays a role in attenuating cartilage degeneration in osteoarthritis through enhancing UCH37-mediated ALK5 deubiquitination. The findings suggest that ADRM1 may be a promising therapeutic strategy for osteoarthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Kai Sun, Jiahui Luo, Xingzhi Jing, Wei Xiang, Jiachao Guo, Xudong Yao, Shuang Liang, Fengjing Guo, Tao Xu
Summary: The study demonstrated that Hyperoside (Hyp) can inhibit IL-1 beta-induced apoptosis and inflammatory responses in chondrocytes, while regulating the expression of key proteins, suggesting its potential for the treatment of osteoarthritis.
Review
Medicine, Research & Experimental
Xinyue Zhang, Xiaohua Pu, Caixia Pi, Jing Xie
Summary: FGF7, also known as KGF, plays a crucial role in tissue development, wound repair, tumorigenesis, and immune reconstruction. It directs cellular synaptic extension and facilitates functional gap junction communication in the skeletal system. Additionally, it promotes osteogenic differentiation and regulates key molecules in cartilage. However, the molecular mechanism of FGF7 in chondrocyte behaviors and cartilage diseases remains unknown.
Review
Cell Biology
Rongxiang Huang, Zhang Hui, Sun Wei, Duan Li, Wencui Li, Wang Daping, Murad Alahdal
Summary: IRE1 plays a crucial role in regulating the unfolded protein response in the endoplasmic reticulum, affecting cell fate through endonuclease activation. Different levels of IRE1α can impact chondrocyte survival and apoptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jinling Zhang, Fangyue Cheng, Genxiang Rong, Zhi Tang, Binjie Gui
Summary: The study revealed that overexpression of hsa_circ_0005567 promoted M2 macrophage polarization through the miR-492/SOCS2 axis, reducing chondrocyte apoptosis and inhibiting the progression of osteoarthritis.
Review
Immunology
Yikai Liu, Zian Zhang, Chang Liu, Haining Zhang
Summary: Osteoarthritis (OA) is a common disease characterized by severe chronic joint pain and imposes a large burden on elderly people. Sirtuins (SIRTs) play important roles in energy metabolism, cellular processes, and aging. This review summarizes the biological functions of SIRTs in OA pathogenesis, including energy metabolism, inflammation, autophagy, cellular senescence, and their regulation of circadian rhythm. Understanding the role of SIRTs in OA can guide new directions for OA treatment exploration.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Shibo Xu, Linna Chang, Xingjun Zhao, Yanan Hu, Yiyi Lin, Zhenhua Chen, Xiuli Ren, Xifan Mei
Summary: In this study, a multifunctional heterostructure nanoplatform with near-infrared sensitivity was developed for the treatment of osteoarthritis. The results showed that this nanoplatform could reduce cartilage damage and promote cartilage regeneration, providing a promising strategy for osteoarthritis treatment.
ACTA BIOMATERIALIA
(2022)
Article
Geriatrics & Gerontology
Quanzhi Liang, Ailijiang Asila, Yingjie Deng, Jun Liao, Zhenfeng Liu, Rui Fang
Summary: Osteopontin-induced HOTAIR expression is involved in osteoarthritis by regulating cell proliferation. The study found that HOTAIR was upregulated in OA and showed a positive correlation with osteopontin. While osteopontin treatment increased HOTAIR expression in primary chondrocytes, HOTAIR overexpression and knockdown did not significantly affect osteopontin expression. Additionally, both osteopontin and HOTAIR overexpression increased chondrocyte proliferation, while HOTAIR knockdown decreased chondrocyte proliferation and reduced the effects of osteopontin treatment on cell proliferation.
Article
Orthopedics
J. E. Dilley, A. Seetharam, X. Ding, M. A. Bello, J. Shutter, D. B. Burr, R. M. Natoli, T. O. McKinley, U. Sankar
Summary: The role of CAMKK2 in human osteoarthritis was investigated in this study. CAMKK2 mRNA and protein levels were found to be elevated in the articular chondrocytes from human OA cartilage. Inhibition or knockdown of CAMKK2 led to decreased chondrocyte apoptosis and catabolic protein levels, while overexpression of CAMKK2 elevated them. These findings suggest that CAMKK2 may be a potential therapeutic target for the prevention or mitigation of human OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
A. Abou-Jaoude, M. Courtes, L. Badique, D. Elhaj Mahmoud, C. Abboud, M. Mlih, H. Justiniano, M. Milbach, M. Lambert, A. Lemle, S. Awan, J. Terrand, A. Niemeier, A. Barbero, X. Houard, P. Boucher, R. L. Matz
Summary: This study investigates the role of ShcA protein in chondrocyte hypertrophic differentiation and osteoarthritis. Deletion of ShcA reduces the hypertrophic zone of the growth plate and alters the endochondral ossification process, leading to dwarfism. ShcA promotes ERK1/2 activation and nuclear translocation of RunX2, while keeping the Runx2 inhibitor, YAP1, inactive in the cytosol. Furthermore, loss of ShcA protects mice from age-related osteoarthritis development.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Plant Sciences
Jun Chen, Nan Chen, Ting Zhang, Jie Lin, Yunmei Huang, Guangwen Wu
Summary: The study found that RJNTF can alleviate OA cartilage damage by inhibiting the SDF-1/CXCR4-p38MAPK signaling pathway.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yin
Summary: This study found that DIM can inhibit chondrocyte apoptosis and ECM degradation induced by LPS by regulating the PI3K/AKT/mTOR-autophagy axis, thus delaying the progression of osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Rheumatology
Mercedes Fernandez-Moreno, Ignacio Rego-Perez, Francisco J. Blanco
Summary: This article summarizes the evidence that suggests osteoarthritis is a mitochondrial disease, emphasizing the important role of mitochondria in the pathogenesis of OA, such as regulating events like cell apoptosis, autophagy, senescence, and inflammation. Mitochondrial genetic variation may exert signaling control over the nuclear epigenome, modulating the development of OA.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Rheumatology
Maite Silva-Diaz, Francisco J. Blanco, Victor Quevedo Vila, Daniel Seoane-Mato, Fernando Perez-Ruiz, Antonio Juan-Mas, Jose M. Pego-Reigosa, Javier Narvaez, Neus Quilis, Raul Cortes, Antonio Romero Perez, Dolores Fabregas Canales, Teresa Font Gaya, Carolina Bordoy Ferrer, Francisco Javier Prado-Galbarro, Carlos Sanchez-Piedra, Federico Diaz-Gonzalez, Sagrario Bustabad-Reyes
Summary: This study estimated the prevalence of symptomatic axial osteoarthritis in Spain to be 19.17%, with higher rates in older individuals and those with higher body mass index. It was more common in women and in the central region of Spain, and less prevalent in those with higher education levels. Lumbar OA was more frequent than cervical OA and was associated with age and weight status.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Orthopedics
W. Wirth, S. Maschek, A. C. A. Marijnissen, A. Lalande, F. J. Blanco, F. Berenbaum, L. A. van de Stadt, M. Kloppenburg, I. K. Haugen, C. H. Ladel, J. Bacardit, A. Wisser, F. Eckstein, F. W. Roemer, F. P. J. G. Lafeber, H. H. Weinans, M. Jansen
Summary: The study aims to investigate the test-retest precision of cartilage thickness and report longitudinal changes in the IMI-APPROACH cohort. The machine-learning-estimated structural progression score (s-score) was not predictive of cartilage thickness loss.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Carlos Vaamonde-Garcia, Emma Capelo-Mera, Noelia Florez-Fernandez, Maria Dolores Torres, Beatriz Rivas-Murias, Rosa Mejide-Failde, Francisco J. Blanco, Herminia Dominguez
Summary: This study analyzed the therapeutic potential of crude fucoidans in chondrocytes and found that they have partial effectiveness in alleviating inflammation and oxidative stress associated with osteoarthritis, but do not attenuate chondrocyte senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Filip Van den Bosch, James Cheng-Chung Wei, Peter Nash, Francisco J. Blanco, Daniela Graham, Chuanbo Zang, Edmund Arthur, Cecilia Borlenghi, Vassilis Tsekouras, Bonnie Vlahos, Atul Deodhar
Summary: This study investigated the withdrawal and retreatment of etanercept in patients with nr-axSpA achieving inactive disease. The results showed that approximately 25% of patients maintained inactive disease for 40 weeks after discontinuing etanercept. Baseline absence of MRI sacroiliitis and high hs-CRP predicted response maintenance after etanercept withdrawal.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Chemistry, Medicinal
Carmen Nunez-Carro, Margarita Blanco-Blanco, Karla Mariuxi Villagran-Andrade, Francisco J. Blanco, Maria C. de Andres
Summary: In this study, we reviewed the current understanding of epigenetic mechanisms in relation to the pathogenesis of OA, particularly in articular cartilage. Evidence suggests that dysregulation of crucial cartilage molecules is a result of aberrant epigenetic regulatory mechanisms, which contribute to the development and progression of OA. This provides an opportunity to explore new therapeutic targets and novel biomarkers for the disease.
Article
Rheumatology
Unnur Styrkarsdottir, Lilja Stefansdottir, Gudmar Thorleifsson, Olafur A. Stefansson, Saedis Saevarsdottir, Sigrun H. Lund, Thorunn Rafnar, Kazuyuki Hoshijima, Kendra Novak, Natividad Oreiro, Ignacio Rego-Perez, Channing Hansen, Nikolas Kazmers, Lambertus A. Kiemeney, Francisco J. Blanco, Tyler Barker, Margreet Kloppenburg, Michael J. Jurynec, Daniel F. Gudbjartsson, Helgi Jonsson, Unnur Thorsteinsdottir, Kari Stefansson
Summary: This study identified four common sequence variants associated with erosive hand osteoarthritis (EHOA), and identified ALDH1A2, MGP, and BMP6 as causal genes for EHOA. The results support the view of EHOA as a severe subset of hand osteoarthritis and partly separate it from osteoarthritis in larger joints.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alejandro Duran-Sotuela, Mercedes Fernandez-Moreno, Victoria Suarez-Ulloa, Jorge Vazquez-Garcia, Sara Relano, Tamara Hermida-Gomez, Vanesa Balboa-Barreiro, Lucia Lourido-Salas, Valentina Calamia, Patricia Fernandez-Puente, Cristina Ruiz-Romero, Juan Fernandez-Tajes, Carlos Vaamonde-Garcia, Maria C. de Andres, Natividad Oreiro, Francisco J. Blanco, Ignacio Rego-Perez
Summary: This study aimed to investigate the genetic variants in mitochondrial DNA (mtDNA) associated with the risk of rapid progression of knee osteoarthritis (OA) and evaluate their functional significance using a cellular model. The results showed that the mtDNA variant m.16519C was associated with an increased risk of rapid progression of knee OA. The cellular model study further revealed mitochondrial dysfunction and impaired autophagy in cells harboring this variant, which were related to inflammation in OA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Orthopedics
Jose Pinto A. Tasende, M. Fernandez-Moreno, M. E. Vazquez-Mosquera, J. C. Fernandez-Lopez, N. Oreiro-Villar, F. J. De Toro Santos, F. J. Blanco-Garcia
Summary: This study analyzed inflammation and bone destruction/regeneration biomarkers in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), osteoarthritis (OA), and ankylosing spondylitis (AS). It was found that TGF-β1 expression was higher in patients with psoriatic arthritis and correlated with IL-17A and Dkk1 gene expression.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
I. Lorenzo-Gomez, U. Nogueira-Recalde, C. Garcia-Dominguez, N. Oreiro-Villar, M. Lotz, J. A. Pinto-Tasende, F. J. Blanco, B. Carames
Summary: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Cell & Tissue Engineering
M. Pineiro-Ramil, C. Sanjurjo-Rodriguez, S. Rodriguez-Fernandez, T. Hermida-Gomez, F. J. Blanco-Garcia, I. Fuentes-Boquete, C. Vaamonde-Garcia, S. Diaz-Prado
Summary: The aim of this study was to develop immortalized chondrocyte cell lines from articular cartilage of patients with and without osteoarthritis (OA). By transducing primary articular chondrocytes with telomerase reverse transcriptase (hTERT) and SV40 large T antigen (SV40LT), the researchers successfully immortalized the chondrocytes. Although these cell lines were unable to synthesize cartilage-like tissue under the experimental conditions, they retained the ability to respond to IL-113 cytokine, making them advantageous for OA investigation.
BONE & JOINT RESEARCH
(2023)
Article
Cell Biology
Morena Scotece, Carlos Vaamonde-Garcia, Ana Victoria Lechuga-Vieco, Alberto Centeno Cortes, Maria Concepcion Jimenez Gomez, Purificacion Filgueira-Fernandez, Ignacio Rego-Perez, Jose Antonio Enriquez, Francisco J. Blanco
Summary: This study reveals that mtDNA variations have an impact on joint damage during the aging process. By using a conplastic mouse model, it is shown that genetic manipulation of mtDNA can ameliorate joint aging damage, indicating that mtDNA variability is a prognostic factor for aging-related osteoarthritis (OA).
Article
Rheumatology
Natividad Oreiro-Villar, Ana C. Raga, Ignacio Rego-Perez, Sonia Pertega, Maite Silva-Diaz, Mercedes Freire, Carlos Fernandez-Lopez, Francisco J. Blanco
Summary: This article describes the first osteoarthritis cohort in Spain, called PROCOAC, which includes 937 patients with knee, hip, and hand osteoarthritis. The study findings indicate that age, BMI, and total WOMAC score are the only risk factors for involvement of a single location versus three locations.
REUMATOLOGIA CLINICA
(2022)
