4.2 Article

Purifying selection against gene conversions between the polyamine transport (TPO) genes of Saccharomyces species

期刊

CURRENT GENETICS
卷 61, 期 1, 页码 67-72

出版社

SPRINGER
DOI: 10.1007/s00294-014-0445-y

关键词

Saccharomyces cerevisiae; Saccharomyces paradoxus; Saccharomyces mikatae; Gene conversions; Polyamine transport genes; TPO genes; Yeasts; Negative selection

资金

  1. Natural Science and Engineering Research Council of Canada
  2. University of Ottawa

向作者/读者索取更多资源

Saccharomyces species have five TPO genes, TPO1 through TPO5, coding for proteins that are involved in up taking or excreting intracellular spermine, putrescine or spermidine. Here, we investigate the evolutionary fate and functional impacts of gene conversions between these genes. Our results show that gene conversions occurred only between the TPO2 and TPO3 genes of the six Saccharomyces species we studied. They also show that these gene conversions occurred independently in all six species. The facts that they only occur between closely related genes having similar function, and that they are limited to the transmembrane domain of these proteins, suggest that they have little functional impact. These gene conversions therefore likely represent neutral mutations which are not subject to purifying selection.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据