Article
Polymer Science
Ana Mateos-Maroto, Laura Fernandez-Pena, Irene Abelenda-Nunez, Francisco Ortega, Ramon G. Rubio, Eduardo Guzman
Summary: This review provides an updated perspective on the various applications of polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method in the biomedical field, emphasizing the significant advantages offered by the LbL method for fabricating platforms for different disease detection and treatment.
Article
Chemistry, Physical
Liqin Ge, Xin Tan, Renwang Sheng, Jun Xiao
Summary: Giant polyelectrolyte microcapsules (GMs) with huge cavities and extremely low wall-to-diameter ratios were successfully fabricated using microbubbles as templates and layer-by-layer self-assembly technology. They have potential applications as drug delivery systems.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Alexandra M. L. Oliveira, Monica Machado, Gabriela A. Silva, Diogo B. Bitoque, Joana Tavares Ferreira, Luis Abegao Pinto, Quirina Ferreira
Summary: Graphene oxide, with its unique properties, has been widely used in nanomedicine as a component of drug delivery systems. Research studies have demonstrated its effectiveness in controlling drug dosage and timely delivery when incorporated into multilayer films. This review provides an overview of the latest research developments in biomedical applications using graphene oxide for drug delivery systems, including film production and characterization, in vitro and in vivo experiments, main applications of graphene oxide in biomedical devices, and its biocompatibility properties.
Article
Biochemistry & Molecular Biology
Pradeep Kumar Panda, Jen-Ming Yang, Yen-Hsiang Chang
Summary: In this study, ferulic acid-modified water soluble chitosan and poly (gamma-glutamic acid) polyelectrolyte multilayers films were constructed using layer-by-layer self-assembly technique. The films showed good wettability and protein adsorption resistance, indicating their potential as biomaterials for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Peng Li, Muan Yu, Kang Gao, Kuo Chen, Xiujie Yang, Haixiang Sun, Yingfei Hou, Q. Jason Niu
Summary: The polyethyleneimine (PEI)/graphene oxide (GO) film prepared by ultrasonic atomization-assisted technology shows excellent hydrogen barrier properties and saves time and waste liquid compared to traditional methods. The optimal conditions for film preparation were found to be a GO concentration of 0.9 mg ml-1, a spray time of 8 s for PEI and 20 s for GO, a pH of 10 for PEI and 4 for GO, and 25 layers of assembled film. The hydrogen transmission rate of the PEI/GO composite film was significantly lower, by 92.38%, than that of the PET substrate film.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Biochemistry & Molecular Biology
Jo Sing Julia Tang, Aline Debrassi Smaczniak, Lucas Tepper, Sophia Rosencrantz, Mina Aleksanyan, Lars Daehne, Ruben R. Rosencrantz
Summary: This study describes the synthesis of bioinspired glycopolymer electrolytes using protecting group free and aqueous-based methods, fabricated as thin films by Layer-by-Layer self-assembly to serve as scaffolds for liposomes. The results demonstrate the stability and integrity of glycopolymer coatings and embedded liposomes within the physiological pH range.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Engineering, Chemical
Yang Yang, Ye Li, Kunli Goh, Choon Hong Tan, Rong Wang
Summary: The study presents a polyelectrolyte multilayered method for fabricating nanofiltration membranes by integrating dopamine as a bio-glue. The results show that the introduction of multilayers can significantly enhance the water permeability and ion rejection of the membranes. Furthermore, the application of this method on hollow fiber membrane modules also achieved good performance.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Polymer Science
Peng Li, Congcong Miao, Kang Gao, Hongxue Xie, Kuo Chen, Tengteng Xie, Shengchao Zhao, Haixiang Sun, Xiujie Yang, Yingfei Hou, Q. Jason Niu
Summary: Graphene oxide (GO) can be self-assembled with various polymer materials layer by layer to prepare composite materials with excellent barrier properties. However, the process is cumbersome and time-consuming. In this article, GO/polyethyleneimine(PEI) hydrogen barrier films were successfully prepared by ultrasonic-assisted layer-by-layer self-assembly technology. Results show that the ultrasonic-assisted method not only reduced the immersion time from several minutes to 10 s, but also increased the density of the material packing to reduce the channels through which hydrogen molecules can diffuse while improving the horizontal orientation of the GO sheet to prolong the diffusion paths of gas molecules. Finally, the hydrogen transmission rate of 20-bilayer films assembled under ultrasonic conditions is equivalent to that of 30-bilayer films assembled without ultrasonic conditions, which greatly shortens the film-making period. Therefore, the ultrasonic-assisted method has a good prospect in the preparation of gas barrier films.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Gonzalo Eduardo Fenoy, Juliana Scotto, Juan A. Allegretto, Esteban Piccinini, Agustin Lorenzo Cantillo, Wolfgang Knoll, Omar Azzaroni, Waldemar Alejandro Marmisolle
Summary: This work presents the fabrication of PEDOT-PAH-based organic electrochemical transistors (OECTs) and their application in monitoring the deposition of polyelectrolyte multilayers on their surface. The electrical characteristics of the devices are optimized through different synthesis conditions, and the layer-by-layer assembly process is investigated. OECTs are proven to be capable of real-time monitoring the assembly of different polyelectrolyte layers and analyzing the changes in ionic transport. The importance of OECTs in sensing charged macromolecules is demonstrated through comparison with other sensing platforms.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Polymer Science
Choonghyun Sung, Yejin Heo
Summary: This study utilized a blend of cationic and anionic polymers to assemble layer-by-layer films with controlled surface morphologies and increased contact angles under acidic conditions. The lubricated fluorinated films showed improved slippery properties and can potentially serve as slippery surfaces for various applications.
Article
Chemistry, Multidisciplinary
Jiaojiao Zhang, Zixuan Wang, Jiwei Min, Xuelin Zhang, Rongxin Su, Yuefei Wang, Wei Qi
Summary: A transfection formulation is developed using an auxiliary lipid (DOTAP) added to the peptide, resulting in a transfection efficiency of 72.6% for pDNA, which is comparable to Lipofectamine 2000. The designed KHL peptide-DOTAP complex exhibits good biocompatibility and significantly improves mRNA delivery compared to KHL or DOTAP alone. The complex also achieves efficient endolysosomal escape, providing a new platform for enhancing peptide vector transfection efficiency.
Article
Chemistry, Physical
Yana V. Tarakanchikova, Albert R. Muslimov, Mikhail V. Zyuzin, Irina Nazarenko, Alexander S. Timin, Gleb B. Sukhorukov, Kirill V. Lepik
Summary: The LbL polymer capsules show potential as a universal gene delivery platform for transferring mRNA and siRNA effectively into human mesenchymal stem cells. Both micrometer and sub-micrometer-sized capsules can efficiently package and transfer nucleic acids into cells. The versatility of the LbL capsules allows for tuning based on the properties of the genetic cargo.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2021)
Article
Engineering, Environmental
Jiadi Ying, Yuqing Lin, Yiren Zhang, Yan Jin, Hideto Matsuyama, Jianguo Yu
Summary: This study reports a novel cation exchange membrane (CEM) engineered by coating a multilayer [polyethyleneimine/polystyrene sulfonate (PEI/PSS)]n on a polyacrylate substrate membrane. The newly developed CEM exhibits high selectivity for Li+ and Mg2+, demonstrating competitive separation performance compared to state-of-the-art permselective membranes.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Biswa P. Das, Marina Tsianou
Summary: Multilayer thin film assembly by the layer-by-layer (LbL) technique is an inexpensive and versatile route for the synthesis of functional nanomaterials. This study achieves exponential growth in clay-containing polyelectrolyte films with high clay loading and tailored properties by incorporating a weak polyelectrolyte and a clay with high charge density and small particle size. The findings include novel pathways to manipulate film characteristics. The presented strategy can lead to novel approaches to fabricate tailor-made nanomaterials for distinct applications.
Article
Polymer Science
Yi-Wei Chen, Muhammad Haseeb Iqbal, Florent Meyer, Vincent Ball, Fouzia Boulmedais
Summary: The surface properties of biomaterials are crucial for cell behavior. Collagen-based layer-by-layer films were constructed using different macromolecules, such as tannic acid, heparin, and poly(sodium 4-styrene sulfonate). Parameters like pH value, dipping time, and salt concentration were optimized for efficient film buildup. The stability and release of tannic acid from the films were studied, and collagen/tannic acid films showed excellent proliferation of human fibroblasts, supporting their potential as biomedical coatings.