Review
Biochemistry & Molecular Biology
Guojun Qu, Jieqiong Chen, Yangyang Li, Yaqin Yuan, Rui Liang, Bin Li
Summary: CD4(+)FOXP3(+) regulatory T (Treg) cells play a vital role in maintaining immune homeostasis, and Treg cell-based therapies have shown promise in various diseases. Current challenges in Treg cell therapy include emerging clinical trials like CAR-Treg cell therapy and new strategies in engineering Treg cells.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Materials Science, Multidisciplinary
Ivana Jarak, Miguel Pereira-Silva, Ana Claudia Santos, Francisco Veiga, Horacio Cabral, Ana Figueiras
Summary: PMs are efficient NA delivery platforms that can manipulate gene expression and have enormous potential for treating life-threatening diseases. The facile manipulation of polymeric building blocks allows for tuning crucial parameters for NA protection and targeted delivery.
APPLIED MATERIALS TODAY
(2021)
Article
Biochemistry & Molecular Biology
Max Jonathan Stumpf, Nadjib Schahab, Georg Nickenig, Dirk Skowasch, Christian Alexander Schaefer
Summary: PXE is a rare genetic metabolic disease characterized by skin lesions, choroidal neovascularization, and early-onset arterial calcification. It is caused by recessively transmitted pathogenic variants of the ABCC6 gene, leading to a deficiency of ABCC6 protein. Treatments for PXE are either outdated or not widely available, presenting challenges for clinical physicians and patients.
Review
Immunology
Manasi P. Jogalekar, Ramya Lakshmi Rajendran, Fatima Khan, Crismita Dmello, Prakash Gangadaran, Byeong-Cheol Ahn
Summary: CAR-T cell therapy is a promising immune cell therapy for cancer, showing remarkable clinical responses in B-cell leukemia or lymphoma. However, it still faces challenges in treating other hematological and solid tumor malignancies, including severe toxicities and limited anti-tumor efficacy. This review discusses innovative CAR T-cell strategies to improve treatment outcomes and addresses the current challenges and new developments in CAR T-cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ruolan Xia, Yuan Cheng, Xuejiao Han, Yuquan Wei, Xiawei Wei
Summary: Ikaros is a crucial transcription factor involved in tumorigenesis, with therapeutic strategies targeting it showing promising effects in clinical trials. However, the emerging issue of drug resistance to Ikaros-targeted therapy is becoming increasingly prominent.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Engineering, Multidisciplinary
Thunwa Binlateh, Peungchaleoy Thammanichanon, Pawornwan Rittipakorn, Natthapol Thinsathid, Paiboon Jitprasertwong
Summary: This review focuses on the applications of collagen-based biomaterials in periodontal regeneration. Collagen can be derived from various sources, including animal, marine, and plant extracts, as well as recombinant human type I collagen. Animal-derived collagen has limitations due to concerns such as contamination and immunogenicity, while recombinant human type I collagen offers a potential solution. The review provides an overview of current applications and future perspectives of collagen-based biomaterials in periodontal regeneration.
Review
Oncology
Marius Maucher, Micha Srour, Sophia Danhof, Hermann Einsele, Michael Hudecek, Ibrahim Yakoub-Agha
Summary: CAR-T cell therapy shows promise in AML treatment, with challenges lying in identifying suitable target antigens and implementing it clinically.
Review
Biochemistry & Molecular Biology
Alessia Nuzzi, Francesco Pozzo Giuffrida, Saverio Luccarelli, Paolo Nucci
Summary: Corneal blindness ranks fifth globally as a cause of blindness, and regenerative medicine for corneal diseases shows potential with a focus on innovative surgical techniques. The main goal is to restore function by providing viable cells through a novel therapeutic approach. Interest in corneal epithelium rehabilitation medicine is growing rapidly due to external insults on the corneal outer layers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ugur Sener, Michael W. Ruff, Jian L. Campian
Summary: Glioblastoma is the most common malignant brain tumor, and immunotherapy approaches for its treatment are still challenging, although multiple studies are underway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Chiara Pisciotta, Paola Saveri, Davide Pareyson
Summary: Effective drug treatment for Charcot-Marie-Tooth neuropathies (CMT) is still unavailable, with current management relying on rehabilitation therapy, surgery, and symptomatic treatment. Challenges include finding disease-modifying therapies and approaches like gene silencing, gene therapy, and compound interventions are being investigated. Various potential therapeutic strategies targeting different aspects of CMT are under development and testing.
Review
Biochemistry & Molecular Biology
Semira Sheikh, Denis Migliorini, Noemie Lang
Summary: CD19 auto-CAR T cell therapy has been successful in treating relapsed and/or refractory non-Hodgkin lymphomas, leading to significant response rates and prolonged remissions. It has gained regulatory approval and is now being considered for earlier lines of therapy.
Review
Biotechnology & Applied Microbiology
Luis Alberto Bravo-Vazquez, Andrea Mendez-Garcia, Alma L. L. Rodriguez, Padmavati Sahare, Surajit Pathak, Antara Banerjee, Asim K. K. Duttaroy, Sujay Paul
Summary: MicroRNAs (miRNAs) are RNA molecules that regulate gene expression and their dysregulation is associated with cancer. Artificial miRNAs have shown promising results against cancer, but their targeted delivery is challenging. This review evaluates nanotechnology-based miRNA drug delivery systems for cancer therapeutics and discusses potential challenges and future directions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Filipa Lopes-Coelho, Filipa Martins, Sofia A. Pereira, Jacinta Serpa
Summary: Anti-angiogenic therapy aims to fight cancer by disrupting the nutrient and oxygen supply to tumor cells, mainly by targeting vascular endothelial growth factor (VEGF). While some drugs in this category can enhance immune therapy, they often fall short in terms of efficacy. Researchers believe that targeting alternative angiogenic pathways in combination could be a promising solution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fabiana Mallone, Roberta Costi, Marco Marenco, Rocco Plateroti, Antonio Minni, Giuseppe Attanasio, Marco Artico, Alessandro Lambiase
Summary: Ocular fibrosis, a major area of unmet need in ophthalmology and medicine, lacks effective treatments due to potentially blinding side effects of current therapies. Research progress includes biological mechanisms, gene therapy, chemical inhibitors, and exploration of angiogenetic and biomechanical factors, with promising results offering potential for clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Benjamin Deniau, Maria Rosa Costanzo, Karen Sliwa, Ayu Asakage, Wilfried Mullens, Alexandre Mebazaa
Summary: Acute heart failure is the most frequent cause of unplanned hospital admission in patients older than 65 years. The symptoms and clinical signs are mainly related to venous congestion, and the management should be based on the latest guidelines for pharmacological and non-pharmacological treatments.
EUROPEAN HEART JOURNAL
(2023)
