期刊
CURRENT GENE THERAPY
卷 10, 期 3, 页码 214-225出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652310791321251
关键词
Baculovirus; viral vector; transduction; cancer therapy
资金
- Institute of Bioengineering and Nanotechnology
- Biomedical Research Council
- Agency for Science, Technology and Research (A*STAR) in Singapore
- National Medical Research Council [NMRC/1119/2007, NMRC/1203/2009]
- Ministry of Education of Singapore [T206B3110]
Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice.
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