期刊
CURRENT GENE THERAPY
卷 8, 期 6, 页码 483-488出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652308786848067
关键词
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资金
- California Institute for Regenerative Medicine fellowship
- National Heart, Lung, and Blood Institute (NHLBI) [R01HL053670]
Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.
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