Article
Multidisciplinary Sciences
Jong-Ho Park, Sun U. Kwon, Hyuk Sung Kwon, Sung Hyuk Heo
Summary: Prior ICH is associated with WMH severity, increasing the risk of both ischemic and hemorrhagic stroke. In patients with ICH, advanced WMH is linked to higher risk of ischemic stroke, while mild WMH is associated with increased risk of hemorrhagic stroke.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Mengying Yu, Dongqin Zhu, Zhixian Luo, Zhifang Pan, Yunjun Yang, Haoli Xu
Summary: This study aimed to investigate the correlation between white matter lesion (WML) severity and delayed intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH), as well as the association between WML and baseline IVH. The results showed that moderate-severe WML was an independent risk factor for both delayed IVH and baseline IVH.
NEUROCRITICAL CARE
(2022)
Review
Clinical Neurology
Xiongjie Fu, Guoyang Zhou, Jianfeng Zhuang, Chaoran Xu, Hang Zhou, Yucong Peng, Yang Cao, Hanhai Zeng, Jianru Li, Feng Yan, Lin Wang, Gao Chen
Summary: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity, mortality, and disability rates. Research indicates that the development of white matter injury (WMI) following ICH is complex and determines the prognosis of patients. Comprehensive treatment and understanding the relationship between WMI and other brain cells may reveal therapeutic targets for ICH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Christopher J. Love, Daniel Kirschenbaum, Magdy Selim, Eng H. Lo, Elisabeth Rushing, Myron Spector, Adriano Aguzzi
Summary: The study found that chronic hemorrhagic stroke lesions contain abundant collagenous material, primarily consisting of collagen 3. The collagenase rat model successfully reproduced the morphology and composition of chronic human hemorrhagic stroke lesions. By identifying new pathological features of hemorrhagic stroke lesions, these results are important for treatment and recovery strategies.
Article
Clinical Neurology
Maria Luisa Capuana, Svetlana Lorenzano, Maria Chiara Caselli, Maurizio Paciaroni, Danilo Toni
Summary: The study aimed to evaluate the association between cerebral microbleeds (CMBs) and white matter disease (WMD) with intracerebral hemorrhage (ICH) after IV thrombolysis (IVT) with rt-PA. Results suggest that excluding eligible candidates for IV rt-PA treatment solely based on the presence of CMBs is not justified. Clinical decisions should be made on a case-by-case basis and more data is needed to assess the benefit-risk profile of rt-PA in patients with numerous microbleeds.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Mangmang Xu, Qian Wu, Yajun Cheng, Shuting Zhang, Wendan Tao, Shihong Zhang, Deren Wang, Ming Liu, Bo Wu
Summary: This study aimed to investigate the distribution of Circle of Willis morphology and its association with intracerebral hemorrhage etiology and cerebral small vessel disease burden. The study found that CoW morphology was associated with the etiology of ICH and the burden of CSVD.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Yuji Shiga, Shiro Aoki, Naohisa Hosomi, Ryota Nomura, Masahiro Nakamori, Tomohisa Nezu, Keisuke Tachiyama, Teppei Kamimura, Naoto Kinoshita, Ryo Shimomura, Yuki Hayashi, Hayato Matsushima, Eiji Imamura, Hiroki Ueno, Shinichi Wakabayashi, Kazuhiko Nakano, Tatsuo Kohriyama, Hirofumi Maruyama
Summary: This study identified an association between the presence of cnm-positive S. mutans and DWI hyperintensities in patients with acute ICH.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Mingxu Xia, Ya Su, Jiayu Fu, Jiajie Xu, Qiong Wang, Feng Gao, Yong Shen, Qiang Dong, Xin Cheng
Summary: This study found that serum MMP-2 levels in the acute phase may serve as a promising biomarker to predict CAA-ICH recurrence and evaluate the risk of cognitive impairment. Additionally, higher levels of MMP-2 were associated with cerebral microbleeds count and MRI burden score.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Laurent Puy, Antoine Rauch, Vincent Deramecourt, Charlotte Cordonnier, Vincent Berezowski
Summary: This study conducted a postmortem examination to investigate acute microvascular lesions (microbleeds and microinfarcts) in the perihematomal area of patients with spontaneous intracerebral hemorrhage (ICH). It was found that these lesions may contribute to secondary brain tissue damage.
Article
Endocrinology & Metabolism
Heng Yang, Wei Ni, Pengju Wei, Sicheng Li, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Liangfu Zhou, Yuxiang Gu
Summary: Inhibition of HDACs can reduce neuroinflammation and white matter damage after ICH by modulating microglia/macrophage polarization, leading to improved neurological functional recovery.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Xiaodong Ye, Yuchao Jia, Guini Song, Xiaoyan Liu, Chuyue Wu, Guo Li, Xu Zhao, Xiong Wang, Shanshan Huang, Suiqiang Zhu
Summary: This study aimed to investigate the risk factors for the multispot pattern in intracerebral hemorrhage (ICH) related to cerebral small vessel disease (CSVD). The results showed that possession of APOE ε2 and severe CSO-PVS were independently associated with the multispot pattern, which has potential diagnostic significance for cerebral amyloid angiopathy (CAA).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman
Summary: White matter hyperintensity volume is modestly positively associated with elevated amyloid in older adults without dementia, with a stronger association observed among Black participants. However, there was no association between white matter microstructure and elevated amyloid. These findings need to be further validated in larger, multiethnic cohorts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
David J. J. Roh, Amelia Boehme, Rayan Mamoon, Destiny Hooper, Azzurra Cottarelli, Robin Ji, Eric Mao, Aditya Kumar, Fernanda Carvalho Poyraz, Stacie L. L. Demel, Vadim Spektor, Jerina Carmona, Eldad A. A. Hod, Natasha Ironside, Jose Gutierrez, Jia Guo, Elisa Konofagou, Mitchell S. V. Elkind, Daniel Woo
Summary: This study found that higher baseline hemoglobin concentrations were associated with DWI ischemic lesions in patients with ICH. It also suggested a potential relationship between hemoglobin concentration and ICH outcomes. Further research is needed to understand the role of hemoglobin concentration in cerebral small vessel disease and ICH outcomes.
Review
Geriatrics & Gerontology
Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: The article focuses on the pathogenesis and neuroimaging features of white matter lesions (WMLs), revealing a series of pathophysiological findings and discussions about WMLs and providing robust references for clinicians to further understand and customize treatment strategies for different WML patterns caused by vascular etiologies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Imad Derraz, Mohamed Abdelrady, Raed Ahmed, Nicolas Gaillard, Riccardo Morganti, Federico Cagnazzo, Cyril Dargazanli, Pierre-Henri Lefevre, Carlos Riquelme, Lucas Corti, Gregory Gascou, Isabelle Mourand, Caroline Arquizan, Vincent Costalat
Summary: This study aimed to assess whether the burden of white matter hyperintensity (WMH) is associated with an increased risk of symptomatic intracranial hemorrhage (sICH) or poor functional outcome in patients with acute ischemic stroke treated with endovascular thrombectomy (EVT). The results showed that a higher burden of WMH was associated with an increased risk of poor functional outcome at 3 months after EVT.