Article
Biochemistry & Molecular Biology
Mark R. Viggars, Hazel Sutherland, Christopher P. Cardozo, Jonathan C. Jarvis
Summary: Transcriptional assessments of identical nerve-stimulated resistance exercise in mice and rats reveal concordant and discordant gene regulation and pathways related to muscle growth.
Article
Immunology
Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Yuntian Shen, Betty Yuen-Kwan Law, Liang Liu, Xiaosong Gu
Summary: This study revealed that interleukin-6 induces skeletal muscle atrophy through immune receptor activation and a reduction of energy metabolism. Several transcription factors downstream of interleukin-6 were identified as potential regulators of skeletal muscle atrophy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Magdalena C. Liebl, Jutta Moehlenbrink, Huong Becker, Guenter Raddatz, Suhaib K. Abdeen, Rami Aqeilan, Frank Lyko, Thomas G. Hofmann
Summary: DAZAP2 is identified as a novel regulator of the DNA damage-induced p53 response, controlling cancer cell chemosensitivity through interaction with HIPK2 and p53 to modulate gene expression.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Microbiology
Asma Belbelazi, Rachel Neish, Martin Carr, Jeremy C. Mottram, Michael L. Ginger
Summary: In eukaryotes, heme attachment to mitochondrial cytochromes c is catalyzed by two different systems, with one being inherited from the alphaproteobacterial progenitor and the other being a eukaryotic innovation. Unique to euglenozoan protists is the attachment of heme to cytochromes c by a single thioether linkage, with the mechanism remaining unknown. The discovery of kinetoplastid cytochrome c synthetase (KCCS) provides a novel resource for studying eukaryotic cytochrome c maturation and may have wider implications in the context of human genetic diseases.
Editorial Material
Cell Biology
Anais Franco-Romero, Jean Philippe Leduc-Gaudet, Sabah N. A. Hussain, Gilles Gouspillou, Marco Sandri
Summary: Skeletal muscles play key roles in various physiological processes, and autophagy is crucial for muscle mass, function, and integrity. In this study, a novel gene called PHAF1/MYTHO was identified as a regulator of autophagy and muscle integrity. MYTHO/PHAF1 is upregulated in muscle atrophy conditions and downregulation of its expression can prevent muscle atrophy triggered by fasting, denervation, cachexia, and sepsis.
Article
Biochemistry & Molecular Biology
Qi Song, Matthew Ruffalo, Ziv Bar-Joseph
Summary: Inference of global gene regulatory networks from omics data is a long-term goal of systems biology. We developed a new computational method that combines neural networks and multi-task learning to predict RNA velocity rather than gene expression values. Application of our method to atlas scale single cell data from 6 HuBMAP tissues led to several validated and novel predictions and greatly improved on prior methods proposed for this task.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Geriatrics & Gerontology
Tania Cid-Diaz, Saul Leal-Lopez, Fatima Fernandez-Barreiro, Jessica Gonzalez-Sanchez, Icia Santos-Zas, Luis J. Andrade-Bulos, Manuel E. Rodriguez-Fuentes, Carlos S. Mosteiro, Vincent Mouly, Xesus Casabiell, Jose Luis Relova, Yolanda Pazos, Jesus P. Camina
Summary: The obestatin/GPR39 system was found to protect against chronic glucocorticoid-induced muscle atrophy by regulating protein homeostasis and re-establishing protein synthesis balance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Meiricris Tomaz da Silva, Aniket S. S. Joshi, Tatiana E. E. Koike, Anirban Roy, Kavya Mathukumalli, Danesh H. H. Sopariwala, Vihang A. A. Narkar, Ashok Kumar
Summary: In this study, we found that the inhibition of Fn14 improves exercise capacity, resistance to fatigue, and inhibits muscle atrophy. The deletion of Fn14 leads to an increase in oxidative myofibers and capillary number in skeletal muscle. Furthermore, targeted deletion of Fn14 inhibits denervation-induced muscle atrophy.
Article
Biology
Ryan A. Bell, Kenneth B. Storey
Summary: Mammalian hibernation involves significant metabolic changes to promote survival in harsh conditions. Research on 13-lined ground squirrels suggests that skeletal muscle fructose-1,6-bisphosphatase activity is suppressed during torpor, potentially due to structural and functional differences caused by differential acetylation. This study sheds light on skeletal muscle carbohydrate metabolism during hibernation and presents a potential novel mechanism for FBPase regulation under environmental stress.
Article
Oncology
Xianlei Cai, Chao Liang, Miaozun Zhang, Yuan Xu, Yihui Weng, Xueying Li, Weiming Yu
Summary: N6-methyladenosine (m6A) modification plays a significant role in the metabolic reprogramming of digestive system malignancies.
Review
Oncology
Yahui Zhu, Xingrong Lin, Xiaojun Zhou, Edward Prochownik, Fubing Wang, Youjun Li
Summary: Metabolic reprogramming of cancer cells in the tumor microenvironment is driven by increased nutritional, translational, and proliferative demands. Altered lipid metabolism, a marker of tumor progression, is frequently observed in aggressive tumors with poor prognosis. These alterations are influenced by posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors, which impact their activity and localization. This review focuses on the roles of these PTMs and how they contribute to the rewiring of cancer lipid metabolism, particularly in the tumor microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gemma Serra-Bardenys, Sandra Peiro
Summary: Oxidoreductases catalyze oxidation-reduction reactions and constitute a large and diverse group of enzymes. Carbonylation, particularly in lysine residues, is a significant oxidative modification in proteins that can impact protein structure and function.
Article
Cell Biology
Lulu Wei, Ranran Wang, Junaid Wazir, Kai Lin, Shiyu Song, Li Li, Wenyuan Pu, Chen Zhao, Yong Wang, Zhonglan Su, Hongwei Wang
Summary: This study aimed to explore the efficiency of 2-DG in blocking Cori cycle activity and its therapeutic effect on cachexia-associated muscle wasting. The results showed that 2-DG significantly ameliorated cancer cachexia-associated muscle wasting and increased mitochondrial bioenergetic capacity.
Article
Biochemistry & Molecular Biology
Haixia Ma, Valentina Sukonina, Wei Zhang, Fang Meng, Santhilal Subhash, Henrik Palmgren, Ida Alexandersson, Huiming Han, Shuping Zhou, Stefano Bartesaghi, Chandrasekhar Kanduri, Svren Enerback
Summary: In recent years, lactate has been recognized as an important circulating energy substrate and aerobic glycolysis has been identified as a metabolic choice involving increased glucose uptake and lactate production despite normal oxygen levels. This study demonstrates that the transcription factor Foxp1 regulates glucose uptake and lactate production in adipocytes and myocytes. Foxp1 directly interacts with the promoter consensus cis-elements that regulate expression of several enzymes in the glycolytic pathway. Knockdown of Foxp1 suppresses these enzyme levels and impairs glucose uptake and lactate production. This suggests that Foxp1 plays a crucial role in regulating aerobic glycolysis in adipose tissue and muscle.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Immunology
Mei-Ling Yang, Richard G. Kibbey, Mark J. Mamula
Summary: This article summarizes the potential pathological consequences of posttranslational protein modifications (PTMs) and their associated biomarkers in the autoimmune disease type 1 diabetes (T1D), as well as the preventive and therapeutic approaches targeting PTMs to restore normal metabolic pathways in pancreatic islets.
FRONTIERS IN IMMUNOLOGY
(2022)