Article
Chemistry, Multidisciplinary
Yuta Inoue, Yu Matsumoto, Kazuko Toh, Kazuki Miyano, Horacio Cabral, Kazunori Igarashi, Shinichi Iwasaki, Kazunori Kataoka, Tatsuya Yamasoba
Summary: Improving the efficiency of drug delivery systems by manipulating nano-eruptions is a major goal in polymeric micelle research. Compounds like a TGF-beta inhibitor and chloroquine were found to have beneficial effects on intratumoral distribution of DDSs through different mechanisms.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Nanoscience & Nanotechnology
Jaehyun Park, Seokhee Jo, Yeong Mi Lee, Gurusamy Saravanakumar, Junseok Lee, Dongsik Park, Won Jong Kim
Summary: The study utilized specific enzymes with high activity in cancer for cancer diagnosis and tumor-targeted drug delivery. NQO1, an over-expressed enzyme in certain tumor types, inhibits oxidative stress and reacts with QPA to induce micellar structure dissociation for drug release. These findings suggest that NQO1-responsive polymeric micelles have potential for improving therapeutic efficacy in anticancer drug delivery.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Jaehyun Park, Yunyoung Nah, Won Jong Kim
Summary: Indoleamine 2,3-dioxygenase (IDO) is a promising target for cancer immunotherapy as it promotes an immunosuppressive microenvironment in tumor tissue. In this study, swellable micelles triggered by IDO were developed for targeted cancer therapy, which released an IDO inhibitor to recruit effector T-cells into tumor tissue and enhance therapeutic effect.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Applied
Xiaolei Qiu, Shengzhou Ma, Dingfu Wang, Zirui Fan, Peiju Qiu, Shixin Wang, Chunxia Li
Summary: In this study, a novel P-selectin-targeted glycosyl ligand-sulfated polyguluronic acid (PGS) was developed as an oriented carrier for targeted drug delivery system. The PGS-SS-DOX micelles significantly increased tumor cell killing capacity and showed favorable biocompatibility compared to Free-DOX. This work demonstrated the potential of PGS as an ideal low immunogenic and biodegradable drug carrier for treating disseminated tumors.
CARBOHYDRATE POLYMERS
(2023)
Article
Oncology
Kang Pa Lee, Suji Baek, Myeong Sik Yoon, Ji Soo Park, Bok Sil Hong, Sang Ju Lee, Seung Jun Oh, Seung Hae Kwon, Ruda Lee, Dae Ho Lee, Kang-Seo Park, Byung Seok Moon
Summary: In this study, the researchers investigated the apoptotic effect of nanoparticles consisting of aspirin-conjugated 2'-hydroxy-2,3,5'-trimethoxychalcone chemicals on cancer cells. The results showed that these nanoparticles promoted apoptosis in HeLa cells through lipid accumulation, suggesting a novel approach for improving cervical cancer treatment.
Article
Infectious Diseases
Siriporn Okonogi, Pimpak Phumat, Sakornrat Khongkhunthian, Kullapop Suttiat, Pisaisit Chaijareenont
Summary: This study developed a potential natural denture-soaking solution using edible Piper betle extract to combat candidiasis in denture wearers. Loading the extract into polymeric micelles significantly increased its activity, with a minimum fungicidal concentration of 1.5 mg/mL against C. albicans.
Article
Pharmacology & Pharmacy
Sofija Jovanovic Stojanov, Epole N. Ntungwe, Jelena Dinic, Ana Podolski-Renic, Milica Pajovic, Patricia Rijo, Milica Pesic
Summary: Coleon U, a natural compound not recognized as a substrate of P-glycoprotein, has equal efficacy against sensitive and multidrug-resistant cancer cells. It delays the decrease in P-glycoprotein activity by decreasing mitochondrial membrane potential and inhibiting P-glycoprotein expression.
Article
Toxicology
Lottida Phondeth, Rajamanikkam Kamaraj, Julie Nilles, Johanna Weiss, Walter E. Haefeli, Petr Pavek, Dirk Theile
Summary: This study demonstrates that rifabutin can partially mask P-gp induction by binding to the inhibitory site of P-gp with high affinity.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Jun Wu, Quan Wang, Xiaoqi Dong, Min Xu, Juliang Yang, Xiaoqing Yi, Biao Chen, Xiyuan Dong, Ying Wang, Xiaoding Lou, Fan Xia, Shixuan Wang, Jun Dai
Summary: Nanoparticle drug delivery system (NDDS) offers a solution to drug resistance and side effects in traditional chemotherapy. Py-TPE/siRNA@PMP is a multifunctional polymeric nanoparticle designed to combat resistance and side effects in chemotherapy for ovarian cancer, showing promising therapeutic effects in both in vitro and in vivo experiments.
Article
Pharmacology & Pharmacy
Rasmus Blaaholm Nielsen, Rene Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Summary: This study aimed to investigate the potential of the combination of the P-gp inhibitor zosuquidar and the nonionic surfactant polysorbate 20 in potentiating P-gp-mediated efflux inhibition. Cell-based experiments and animal experiments revealed that the combination of these two substances can enhance P-gp inhibition in vitro. However, in vivo experiments showed that coadministration of both substances leads to a decrease in oral etoposide bioavailability.
Article
Chemistry, Multidisciplinary
Sinem Kasapoglu, Cigdem Batigoc, Mesut Boz, Ovul Tetik
Summary: In this study, two cationic gemini surfactants 12-3-12 and 12-3(OH)-12 were synthesized. The CMC values of the surfactants were determined and the aggregation number of micelles was calculated. The corrosion effect, foaming capacity, foam stability, and solubility capability of the surfactants were investigated. The results showed that both surfactants exhibited good inhibitory effect at low concentrations and 12-3(OH)-12 had better foaming properties.
Article
Chemistry, Multidisciplinary
Lara Garcia-Varela, Pascalle Mossel, Pablo Aguiar, Daniel A. Vazquez-Matias, Aren van Waarde, Antoon T. M. Willemsen, Anna L. Bartels, Nicola A. Colabufo, Rudi A. J. O. Dierckx, Philip H. Elsinga, Gert Luurtsema
Summary: This study found that small changes in P-gp function caused by low doses of tariquidar could be detected by [F-18]MC225-K-1 values, confirming the high sensitivity of the radiotracer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, General & Internal
Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Yuanzhen Zhang, Hui Wang
Summary: This study revealed that P-gp plays a critical role in mediating the placental glucocorticoid barrier, with its expression inhibited in IUGR cases. The epigenetic regulation mechanism of P-gp was also explored, providing new insights into early warning, prevention, and treatment strategies for IUGR.
Article
Chemistry, Medicinal
Hiroki Morishita, Liyanage Manosika Buddhini Perera, Xieyi Zhang, Kenta Mizoi, Masa-aki Ito, Kentaro Yano, Takuo Ogihara
Summary: The combined use of Pimozide with other drugs may increase the risk of cardiac arrest. This study investigated the accumulation of Pimozide in cardiomyocytes and its inhibitory effect on cardiac channels, showing that Pimozide accumulation is influenced by other drugs, leading to an increased risk of channel inhibition.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Diogo Henrique Kita, Gisele Alves de Andrade, Juliana Morais Missina, Kahoana Postal, Viktor Kalbermatter Boell, Francielli Sousa Santana, Ingrid Fatima Zattoni, Isadora da Silva Zanzarini, Vivian Rotuno Moure, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Emanuel Maltempi de Souza, David A. Mitchell, Suresh Ambudkar, Giovana Gioppo Nunes, Glaucio Valdameri
Summary: The study found that polyoxovanadates can serve as inhibitors of ABC drug transporters, selectively inhibiting P-glycoprotein with V-10 and V-18 being the most promising compounds.
Review
Pharmacology & Pharmacy
Rania Awad, Avi Avital, Alejandro Sosnik
Summary: Neurodegenerative diseases and neurodevelopmental disorders are challenging to treat due to the blood-brain barrier. The nose-to-brain pathway offers a promising solution, especially for intranasally administered nanoparticle drugs. Polymeric nanocarriers have shown great potential in improving drug bioavailability in the brain. This review provides an overview of the challenges faced and the contribution of intranasal nano-drug delivery systems in treating CNS conditions.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Materials Science, Biomaterials
Alfonso Bayon-Fernandez, Alejandro Mendez-Ardoy, Carmen Alvarez-Lorenzo, Juan R. Granja, Javier Montenegro
Summary: This article introduces the design principles of a new family of self-assembling cyclic octapeptides that can be used as scaffolds for the development of self-healing hydrogels. By inserting different aromatic aldehyde pendants to modulate the hydrophobic/hydrophilic balance and fine-tune the properties of the resulting gel, self-healable hydrogels with viscoelastic properties can be formed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Instruments & Instrumentation
Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Carmen Alvarez-Lorenzo, Maria Vivero-Lopez, Angel Concheiro
Summary: This study demonstrates the spontaneous formation of anisotropic gold nanoparticles (AuNPs) inside preformed contact lenses (CLs) without the need for additional reductant agents. The formation of AuNPs was achieved through a precise tuning of the monomeric composition, saline concentration, and the use of steam heat sterilization. The potential applications of incorporating AuNPs in CLs in the ocular field for prophylaxis, therapy, and diagnosis are highlighted. The developed CLs also exhibit photoresponsiveness and efficient filtering of highly penetrant light.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Carmela Tommasino, Giulia Auriemma, Carla Sardo, Carmen Alvarez-Lorenzo, Emilia Garofalo, Silvana Morello, Giovanni Falcone, Rita P. Aquino
Summary: In this study, a PCL/INU-PLA hybrid biomaterial was prepared, which showed improved surface properties, swelling ability, and in vitro biodegradation rate compared to PCL alone. The 3D printed scaffolds exhibited dimensional and structural parameters close to the digital model and showed favorable results in biocompatibility and osteogenic activity tests.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Kathleen Abigail Montoya-Villegas, Mirian Angelene Gonzalez-Ayon, Carmen Alvarez-Lorenzo, Angel Licea-Claverie, Emilio Bucio, Alejandro Ramirez-Jimenez
Summary: Thermo-responsive, hydrophilic, hemo- and biocompatible poly(DEGMA-co-OEGMA) was grafted onto silicone rubber using the gamma-radiation pre-irradiation method. The size of the grafted chains was controlled using a RAFT agent. The grafted materials showed enhanced hydrophilicity and excellent hemo- and cytocompatibility, indicating potential applications in the biomedical field.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Axel Kattar, Ana Quelle-Regaldie, Laura Sanchez, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The aim of this study was to develop cationic niosomes for the ocular delivery of epalrestat, a drug used in the treatment of diabetic eye damage. The niosomes were characterized and found to have a size of 80 nm, a charge ranging from -23 to +40 mV, and a spherical shape. The encapsulation efficiency of the niosomes was 99.76% and they showed a sustained release of the drug over 20 days. The niosomes were non-irritating, non-toxic, and showed higher permeation in the sclera compared to the unencapsulated drug.
Review
Engineering, Biomedical
Mariana Zarur, Alejandro Seijo-Rabina, Alvaro Goyanes, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: This review focuses on the recent advances in pH-responsive polymer-based scaffolds that have been demonstrated in vivo to be suitable for wound and bone healing. pH plays a critical role in the tissue regeneration process, and small changes can significantly impact the healing process. Various strategies, including changes in ionization of natural polymers, ionizable monomers and clays, reversible cross-linkers, coatings, and production of CO2 gas, have been tested to prepare pH-responsive scaffolds. These techniques have shown promise in achieving biocompatible and environment-friendly scaffolds that can be translated to clinical applications.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Ivan Zlotver, Alejandro Sosnik
Summary: Sonodynamic therapy (SDT) is an effective anti-cancer strategy that utilizes sono-responsive hybrid nanomaterials to generate reactive oxygen species (ROS) upon ultrasound irradiation. This study synthesized and characterized sonodynamic hybrid nanomaterials composed of titanium dioxide and an amphiphilic block copolymer, and investigated their efficiency in vitro and in vivo. The results showed that glucosylated hybrid nanoparticles exhibited significantly higher sonodynamic efficiency compared to unmodified ones. Furthermore, by controlling the nanoparticle size and surface features, the accumulation of nanoparticles in tumors was increased, resulting in prolonged animal survival and significantly reduced tumor volumes in a mouse model of rhabdomyosarcoma.
Article
Engineering, Biomedical
Carmen Alvarez-Lorenzo, Mariana Zarur, Alejandro Seijo-Rabina, Barbara Blanco-Fernandez, Isabel Rodriguez-Moldes, Angel Concheiro
Summary: The imbalance between life expectancy and quality of life is increasing due to the raising prevalence of chronic diseases. Scaffolds that can mimic natural physical stimuli and deliver dynamic physical stimuli, such as electrical signals, have shown potential for more efficient tissue regeneration.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Biomaterials
Alejandro Sosnik, Ivan Zlotver, Ella Peled
Summary: This study investigates the effect of drug-free self-assembled hydrolyzed galactomannan-poly(methyl methacrylate) nanoparticles on the activation of macrophages. Results show that the nanoparticles are cell compatible, upregulate metallothionein genes, and induce the release of anti-inflammatory cytokines by macrophages. These findings suggest the potential application of hGM-g-PMMA nanoparticles in inflammation therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Paola Carou-Senra, Lucia Rodriguez-Pombo, Atheer Awad, Abdul W. Basit, Carmen Alvarez-Lorenzo, Alvaro Goyanes
Summary: Inkjet printing (IJP) enables precise material deposition for personalized medicine and drug delivery. This review explores the formulation and components of pharma-inks, various substrate materials, and potential improvements through hardware, software, and artificial intelligence integration. Further exploration and optimization are needed to fully harness the healthcare capabilities of IJP.
ADVANCED MATERIALS
(2023)
