Review
Biochemistry & Molecular Biology
Lingling Jiang, Weiqi Chen, Jinyi Ye, Yilong Wang
Summary: Ischemic stroke is a life-threatening disease that causes disability and death globally. Currently, there are no effective treatments available in clinical practice, but exosome-based therapy has shown potential. Exosomes play a positive role in neurorestoration through the delivery of microRNA cargo, providing a viable treatment strategy for ischemic stroke patients.
Review
Chemistry, Multidisciplinary
Jianglong Kong, Runxuan Chu, Yi Wang
Summary: Stroke is a major cause of death and disability worldwide. Neuroprotective therapy, combined with thrombolytic therapy, is an important treatment for stroke.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yanpeng Jia, Yi Zhang, Wenjun Zhan, Yu Wang, Xianbao Sun, Yuan Zhang, Xiaoyang Liu, Bing Han, Ying Bai, Ling Shen, Gaolin Liang, Honghong Yao
Summary: Ischemic stroke is a leading cause of death and disability globally. The challenge of poor drug delivery to ischemic regions is addressed by co-assembling curcumin and edaravone with a hydrogelator to create a supramolecular peptide hydrogel (EDV/Cur/NapFFY). This delivery system improves bioavailability and precisely transports the hydrophobic drugs to the ischemic sites, demonstrating potential for promoting repair and recovery of ischemic stroke.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Nutrition & Dietetics
Ewa Zielinska-Nowak, Natalia Cichon, Joanna Saluk-Bijak, Michal Bijak, Elzbieta Miller
Summary: Nutrition and rehabilitation are crucial in post-stroke recovery, especially for elderly patients. Developing tailored nutrition strategies and promoting neuroprotective diets can improve functional recovery during and after rehabilitation, while reducing the risk of developing nutrition-related chronic diseases.
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Pharmacology & Pharmacy
Eman A. Bseiso, Sarah A. AbdEl-Aal, Maha Nasr, Omaima A. Sammour, Nabaweya A. Abd El Gawad
Summary: This study prepared and characterized lipidic nanocapsules loaded with melatonin and demonstrated their efficacy in treating ischemic stroke. The results showed that the nanocapsules had good stability and sustained release ability, and achieved efficient drug permeation across sheep nasal mucosa. The study also found that MEL-LNCs could reduce oxidative stress, decrease inflammatory response, and promote neuronal survival.
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Ischemic stroke is a leading cause of death and disability globally, requiring urgent development of neuroprotective approaches due to limited treatment options. This study provides an overview of current research in neuroprotective stroke treatment, including traditional drugs targeting inflammation, cell death, and excitotoxicity, as well as stem-cell-based and extracellular vesicle-based methods. The review also discusses the potential of the microbiota-gut-brain axis as a target for future neuroprotective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yacong He, Shuang Chen, Bun Tsoi, Shuhua Qi, Bing Gu, Zhenxing Wang, Cheng Peng, Jiangang Shen
Summary: The study found that by inducing the BDNF signaling pathway, AOM can promote adult hippocampal neurogenesis and improve cognitive impairments after stroke. P-CA is identified as the most effective compound in AOM, with the ability to activate the BDNF/TrkB/AKT signaling pathway and promote NSC proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Andone, Lenard Farczadi, Silvia Imre, Rodica Balasa
Summary: This study aimed to analyze the impact of an extended lipid profile, including fatty acids as potential neuroprotective biomarkers, on the outcome of ischemic stroke patients. The results revealed a negative correlation between serum cholesterol and triglycerides with the prognosis of stroke patients, while eicosapentaenoic acid showed potential neuroprotective effects in preventing severe ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Leilei Zhang, Jingying Ma, Fan Yang, Sishi Li, Wangran Ma, Xiang Chang, Lin Yang
Summary: Ischemic stroke is a recurring and disabling condition with limited treatment options. Quercetin, a flavonoid found in fruits and vegetables, has been shown to have neuroprotective effects in pre-clinical studies on patients with ischemic brain injury. However, its specific mechanism of action is still unknown. This review aims to explore the potential value of quercetin in treating ischemic brain injury by examining published data on its plant sources, pharmacological effects, and metabolic processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hui Zhao, Liyi He
Summary: Ischemic stroke leads to severe cellular loss and impairment of brain function. This study introduces a hydrogel-based tissue engineering technique using sericin, a silk protein, to promote neuronal repair. The genipin conjugated sericin hydrogels (Gen-SH) show high porous morphology and aid in neuronal attachment and development in vitro. In vivo transplantation of Gen-SH demonstrates high cell survival and proliferation. This biomaterial can serve as an effective carrier for ischemic stroke treatment and care by delivering neuronal cells and protecting them from oxidative damage.
JOURNAL OF EXPERIMENTAL NANOSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Karol Chojnowski, Mikolaj Opielka, Wojciech Nazar, Przemyslaw Kowianski, Ryszard T. Smolenski
Summary: Guanosine is a nucleotide metabolite that acts as a neuroprotective agent in neurological disorders, particularly in brain ischemia, by counteracting destructive events, regulating inflammatory processes, and activating prosurvival signaling pathways. Studies have shown promising results in vivo, with guanosine therapy leading to decreased infarct volume, improved neurological outcomes, and stimulation of neuroregeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Yi-Li Chen, Yu-Chen Chen, Lin-An Xiong, Qu-Yang Huang, Ting-Ting Gong, Yan Chen, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: Compounds of natural sources are widely discovered in the treatment of ischemic stroke. Alpha-mangostin, a natural prenylated xanthone, has therapeutic potential, but its direct application is limited. Therefore, structural modification of alpha-mangostin was necessary. 34 alpha-mangostin phenylcarbamoyl derivatives were synthesized and evaluated, with compound 2 showing the most therapeutic potential and proving to have powerful effects in animal models.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Clinical Neurology
Yang Jiang, Zhenquan Liu, Yan Liao, Shuyong Sun, Yajie Dai, Yibo Tang
Summary: Ischemic stroke is difficult to treat due to its complex pathological mechanisms, limited treatment options, and microcirculation disorders. Therefore, finding suitable pathways and targets from the pathological mechanism is crucial for the development of effective treatments.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biology
Constantin Munteanu, Mariana Rotariu, Marius Turnea, Ligia Gabriela Tataranu, Gabriela Dogaru, Cristina Popescu, Aura Spinu, Ioana Andone, Elena Valentina Ionescu, Roxana Elena Tucmeanu, Carmen Oprea, Alin Tucmeanu, Carmen Nistor Cseppento, Sinziana Calina Silisteanu, Gelu Onose
Summary: Lithium is a subject of great scientific interest due to its simple structure, easy-to-analyze chemistry, and well-established physical properties, but its complex effects on biological systems are still not fully understood by modern science.