Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jeanne Garcia, Cecile Hubsch, Ana Marques, Jean-Marc Gurruchaga, Cedric Lamirel, Emmanuel Roze, Antoine Moulignier
Summary: The study demonstrated that STN-DBS is a safe and effective treatment for PLHIV with Parkinson's disease, significantly improving symptoms without major adverse events; impulse control disorders were fully resolved after surgery.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Neurosciences
Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
Summary: The long-term therapeutic efficacy of STN-DBS can be achieved in southern China with relatively low stimulation intensity and medication dosage, maintaining motor improvement and medication reduction through an 8-year follow-up, while improvement in quality of life lasts for only 3 years. No definite changes in nonmotor symptoms were found after STN-DBS.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Kim, Jed Noel A. Ong, Hye Ran Park, Sun Ha Paek, Beomseok Jeon
Summary: This study aimed to investigate mortality and factors associated with mortality and causes of death after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. The results showed that 18.7% of patients died, with pneumonia being the most common cause of death. Older age, earlier disease onset, higher preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Danilo Genovese, Francesco Bove, Leonardo Rigon, Tommaso Tufo, Alessandro Izzo, Paolo Calabresi, Anna Rita Bentivoglio, Carla Piano
Summary: This study assessed the clinical safety and efficacy of frameless bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients at 5 years after surgery. The results demonstrate that this technique is safe and well-tolerated, with sustained motor efficacy at 5 years post-surgery.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Hye Ran Park, Hyung-Jun Im, Jeongbin Park, Byung Woo Yoon, Yong Hoon Lim, Eun Jin Song, Kyung Ran Kim, Jae Meen Lee, Kawngwoo Park, Kwang Hyon Park, Hyun Joo Park, Jung-Hwan Shin, Kyung Ah Woo, Jee Young Lee, Suyeon Park, Han-Joon Kim, Beomseok Jeon, Sun Ha Paek
Summary: This study investigated the survival rate and long-term outcome of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). The study found that the Unified Parkinson's Disease Rating Scale (UPDRS) score significantly improved until 5 years after surgery, but showed a tendency to increase again after 10 years. Additionally, patients with both electrodes located within the STN had a higher survival rate and maintained ambulation.
Article
Clinical Neurology
Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Carla Budriesi, Valentina Fioravanti, Giulia Di Rauso, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Noemi Guagnano, Elisa Bardi, Maria Giulia Corni, Jessica Rossi, Francesca Antonelli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Giuseppe Vannozzi, Elena Bergamini, Giacomo Pavesi, Sara Meoni, Valerie Fraix, Alessandro Fraternali, Annibale Versari, Mirco Lusuardi, Giuseppe Biagini, Andrea Merlo, Elena Moro, Franco Valzania
Summary: This study assessed the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on gait in advanced Parkinson's Disease (PD) patients. The results showed that in the long-term after surgery, STN-DBS can contribute to gait and postural control improvement when used together with dopamine replacement therapy.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Bernadette C. M. van Wijk, Rob M. A. de Bie, Martijn Beudel
Summary: Deep brain stimulation (DBS) treatment has been effective in suppressing symptoms of Parkinson's disease, but patients may experience fluctuations in symptom severity throughout the day. Adaptive DBS (aDBS) aims to optimize treatment by adjusting stimulation settings based on the presence or absence of symptoms. This research synthesis focuses on the correlation between local field potential (LFP) signal features and specific PD motor symptoms, particularly bradykinesia and rigidity.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jan Hirschmann, Alexandra Steina, Jan Vesper, Esther Florin, Alfons Schnitzler
Summary: This study demonstrates for the first time that neuronal oscillations are predictive of deep brain stimulation (DBS) outcome. Coherence between subthalamic and parietal oscillations are particularly informative.
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Review
Neurosciences
Julien Fiorilli, Jeroen J. Bos, Xenia Grande, Judith Lim, Emrah Duezel, Cyriel M. A. Pennartz
Summary: The perirhinal cortex plays a crucial role as a transition area between the sensory neocortex and the medial temporal lobe, involved not only in object coding and spatial processing, but also in solving feature ambiguity and processing complex stimuli. This brain region has the ability to merge different features into a single entity, flexibly deploying network circuits for various cognitive functions depending on behavioral demands.
Review
Clinical Neurology
Thomas Edmund Cope, Rimona Sharon Weil, Emrah Duezel, Bradford C. Dickerson, James Benedict Rowe
Summary: Advances in neuroimaging technologies facilitate the translation of progress in cellular genetics and molecular biology into improved diagnosis, prevention and treatment for dementia. New PET ligands and MRI-based imaging provide safe and reliable methods for quantifying neuropathology, inflammation and brain function, enhancing our understanding of human pathophysiology. The combination of large datasets, open data and artificial intelligence analysis methods enable accurate single-subject inferences for precision medicine in dementia.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Neurosciences
Joram Soch, Anni Richter, Hartmut Schuetze, Jasmin M. Kizilirmak, Anne Assmann, Lea Knopf, Matthias Raschick, Annika Schult, Anne Maass, Gabriel Ziegler, Alan Richardson-Klavehn, Emrah Duezel, Bjorn H. Schott
Summary: Subsequent memory paradigms separate brain responses based on memory performance during later retrieval, with fMRI typically showing activations in certain brain structures. This study suggests that using parametric models, especially with non-linear transformations of memory confidence ratings, can better explain fMRI signal variance during encoding, providing a framework for improving models of encoding-related activations and applying them to memory-impaired individuals.
Correction
Clinical Neurology
Anni Richter, Lieke de Boer, Marc Guitart-Masip, Gusalija Behnisch, Constanze I. Seidenbecher, Bjoern H. Schott
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Neurosciences
Marlen Schmicker, Inga Menze, Christine Schneider, Marco Taubert, Tino Zaehle, Notger G. Mueller
Summary: The study suggests that transcranial direct current stimulation (tDCS) can enhance transfer effects on working memory (WM), especially in individuals with high WM capacity. However, in individuals with low WM capacity, tDCS may reduce transfer effects on WM. This highlights the importance of adjusting tDCS protocols based on individual differences in WM capacity.
Article
Clinical Neurology
Emrah Duezel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schuetze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bjoern-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H. Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Summary: This study investigated whether the impact of tau-pathology on memory performance and hippocampal/medial temporal memory function depends on the presence of amyloid pathology. The results showed a linear relationship between amyloid pathology, tau pathology, hippocampal dysfunction, and memory impairment.
Article
Multidisciplinary Sciences
Benjamin J. Griffiths, Tino Zaehle, Stefan Repplinger, Friedhelm C. Schmitt, Juergen Voges, Simon Hanslmayr, Tobias Staudigl
Summary: The thalamus plays a significant role in animal cognition and its interaction with the prefrontal cortex can predict perceptual performance. However, little is known about thalamic and thalamocortical contributions to human cognition. This study demonstrates that rhythmic activity in the mediodorsal thalamus and prefrontal cortex predicts the perception of near-threshold visual stimuli, challenging the traditional view of the thalamus as a simple relay.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Maria Kuehne, Laura Polotzek, Aiden Haghikia, Tino Zaehle, Janek S. Lobmaier
Summary: This study investigated the influence of facial mimicry on facial emotion recognition. The results showed that the emotional recognition of the control group was affected by facial mimicry manipulation, while Parkinson's disease patients had impairments in their ability to detect emotion changes. Furthermore, the study found that the facial emotion recognition abilities of Parkinson's disease patients were completely unaffected by mimicry manipulation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle
Summary: This study investigated the potential of P50 sensory gating and prepulse inhibition ratios as surrogate markers for cognitive fatigue in people with multiple sclerosis (pwMS). The results showed that P50 sensory gating was correlated with subjective fatigue ratings. This study is the first to demonstrate fatigue-related disruption of sensory gating in pwMS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle
Summary: This study found that patients with multiple sclerosis (pwMS) show more measurable changes in cognitive fatigability compared to healthy controls. However, these changes in reaction time and brain activity were not associated with subjective fatigue ratings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Immunology
Stefanie Linnhoff, Lilli Koehler, Aiden Haghikia, Tino Zaehle
Summary: After acute COVID-19 infection, many patients continue to experience symptoms for more than four weeks, known as Long-COVID syndrome. Surprisingly, the severity of Long-COVID symptoms is not linked to the severity of the initial infection. Fatigue is a common and debilitating symptom of Long-COVID, and non-invasive brain stimulation methods show promise in reducing fatigue symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Inga Menze, Notger G. Mueller, Tino Zaehle, Marlen Schmicker
Summary: This study compares different electrode montage approaches for transcranial direct current stimulation (tDCS) and finds that frontoparietal network stimulation is superior in improving working memory capacity. The results also highlight the individual variability in the effects of conventional and sham tDCS. This finding contributes to a better understanding of the impact of tDCS on cognitive functions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Beatrice Barbazzeni, Oliver Speck, Emrah Duezel
Summary: Self-regulation of alpha frequency through neurofeedback does not improve working memory maintenance. However, changes in right parietal low-beta power are related to improved working memory accuracy. Working memory performance is influenced by motivational factors, which are associated with specific brain activities, including alpha suppression.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Katharina S. Rufener, Christian Wienke, Alena Salanje, Aiden Haghikia, Tino Zaehle
Summary: This study investigates the effects of pairing tones with transcutaneous auricular vagus nerve stimulation (taVNS) on auditory processing. Results show that taVNS can modulate auditory processing in healthy individuals, suggesting potential applications in auditory disorders.
Review
Clinical Neurology
Elisa Lancini, Lena Haag, Franziska Bartl, Maren Ruehling, Nicholas J. Ashton, Henrik Zetterberg, Emrah Duezel, Dorothea Haemmerer, Matthew J. Betts
Summary: The noradrenergic system undergoes pathological modifications in aging and neurodegenerative diseases, and significant neuronal loss in Alzheimer's disease and Parkinson's disease. A meta-analysis found that individuals with Parkinson's disease had decreased levels of CSF noradrenaline and 3-methoxy-4-hydroxyphenylglycol, as well as noradrenaline transporters availability in the hypothalamus. In Alzheimer's disease dementia, only 3-methoxy-4-hydroxyphenylglycol levels were increased compared to controls. Further studies are needed to understand the association between these biomarkers and clinical symptoms and pathology.
BRAIN COMMUNICATIONS
(2023)