Article
Biochemistry & Molecular Biology
Monica Locatelli, Daniela Rottoli, Rayan Mahmoud, Mauro Abbate, Daniela Corna, Domenico Cerullo, Susanna Tomasoni, Giuseppe Remuzzi, Carlamaria Zoja, Ariela Benigni, Daniela Macconi
Summary: In BTBR ob/ob mice with type 2 diabetic nephropathy, peritubular capillaries show endothelial cell abnormalities and basement membrane thickening. Remodeling and focal loss of the endothelial glycocalyx were observed in diabetic kidneys, and ACEi treatment preserved the glycocalyx and attenuated the ultrastructural abnormalities of peritubular capillaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Taikang Yao, Zhenchao Wu, Zilu Wang, Liting Chen, Beibei Liu, Ming Lu, Ning Shen
Summary: Observational studies and meta-analyses have shown a positive correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer. The study used Mendelian randomization to verify the associations between ACE inhibition, ACEI-induced cough, and the risk of lung cancer. The results indicate a significant relationship between ACE inhibition and the development of lung cancer, as well as a higher risk of lung cancer for Europeans with ACEI-induced cough.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Physiology
Haru Nomura, Sanjaya Kuruppu, Niwanthi W. Rajapakse
Summary: Diabetic nephropathy is a common disease leading to end-stage renal disease. Chronic activation of the RAAS contributes to kidney inflammation and fibrosis, resulting in kidney disease. Targeting the reno-protective arm of the RAAS provides potential therapeutic options for improving kidney inflammation and fibrosis in diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Summary: Ramipril has the potential to prevent paclitaxel-induced peripheral neuropathy, and the neuroprotective role of ramipril in this condition is mediated through the involvement of the AT2 receptor.
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Chris Tikellis, Gardner N. Robinson, Carlos J. Rosado, Duygu Batu, Maria A. Zuniga-Gutierrez, Raelene J. Pickering, Merlin C. Thomas
Summary: The levels of soluble ACE2 increase in diabetes, but its specific role in atherogenesis is unclear. Experimental findings suggest that increasing circulating soluble ACE2 can reduce plaque accumulation and has independent vasculoprotective effects.
Article
Biochemistry & Molecular Biology
Ilaria Caputo, Brasilina Caroccia, Ilaria Frasson, Elena Poggio, Stefania Zamberlan, Margherita Morpurgo, Teresa M. Seccia, Tito Cali, Marisa Brini, Sara N. Richter, Gian Paolo Rossi
Summary: Blockers of the renin-angiotensin system (RAS) can increase the expression of ACE2, the cellular receptor of SARS-CoV-2, and thus increase the risk of COVID-19. This study found that angiotensin II (Ang II) significantly increased the levels of ACE2 expression by acting on the angiotensin type 1 receptor, resulting in enhanced viral entry into cells. However, the blockade of ACE-1-mediated Ang II formation and ACE2-mediated Ang II conversion did not have any effect. Therefore, increased production of Ang II in patients with an activated RAS may lead to a greater spread of COVID-19 infection in lung cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Tomoaki Ida, Kei Ikeda, Hiroyuki Ohbe, Kaito Nakamura, Hiroki Furuya, Taro Iwamoto, Shunsuke Furuta, Yoshihisa Miyamoto, Mikio Nakajima, Yusuke Sasabuchi, Hiroki Matsui, Hideo Yasunaga, Hiroshi Nakajima
Summary: This retrospective cohort study evaluated the effectiveness of early initiation of ACE inhibitor in patients with SRC. The results showed that early ACEi treatment was associated with a lower composite outcome of in-hospital mortality or haemodialysis dependence at discharge. Further prospective studies are needed to confirm these findings.
Article
Physiology
Naoya Kakutani, Shingo Takada, Hideo Nambu, Satoshi Maekawa, Hikaru Hagiwara, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Yoshizuki Fumoto, Soichiro Hata, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa
Summary: Skeletal muscle fibrosis is significantly increased in STZ-induced diabetic mice, but can be prevented by administration of an ACE inhibitor, which also helps to alleviate the reduction in muscle function. These findings suggest a potential new therapeutic target for skeletal muscle abnormalities in diabetes.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Cell Biology
Alexandra M. Garvin, Bilal S. Khokhar, Michael P. Czubryt, Taben M. Hale
Summary: Angiotensin II is a key mediator of profibrotic signaling in the heart, impacting cardiac function and mortality. Inhibitors of Ang II production or action, known as RAS inhibitors, are the first line therapeutics for heart failure, with potential for long-lasting effects on cardiac fibroblast responses.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Carla S. S. Teixeira, Rita Biltes, Caterina Villa, Sergio F. Sousa, Joana Costa, Isabel M. P. L. V. O. Ferreira, Isabel Mafra
Summary: Edible insects are proposed as a sustainable protein source and alternative food. This study simulated the digestion of locust proteins and identified peptides that could selectively inhibit a specific enzyme, potentially providing bioactivity against cardiac and pulmonary fibrosis.
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Moaz M. Abdou, Dewen Dong, Paul M. O'Neill, Eric Amigues, Magdalini Matziari
Summary: In drug discovery, molecular modification of lead molecules is crucial for drug development. This study reports the synthesis of a novel RXPA380-proline hybrid, which showed lower inhibition of ACE compared to the parent compound RXPA380.
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Meeting Abstract
Endocrinology & Metabolism
Mark A. Yorek
Article
Endocrinology & Metabolism
Eric P. Davidson, Lawrence J. Coppey, Hanna Shevalye, Alexander Obrosov, Mark A. Yorek
Article
Endocrinology & Metabolism
Lawrence J. Coppey, Hanna Shevalye, Alexander Obrosov, Eric P. Davidson, Mark A. Yorek
JOURNAL OF DIABETES INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Lawrence Coppey, Eric Davidson, Hanna Shevalye, Alexander Obrosov, Mark Yorek
JOURNAL OF DIABETES RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Brian Fink, Lawrence Coppey, Eric Davidson, Hanna Shevalye, Alexander Obrosov, Pratik Rajesh Chheda, Robert Kerns, William Sivitz, Mark Yorek
FREE RADICAL RESEARCH
(2020)
Meeting Abstract
Endocrinology & Metabolism
Mark A. Yorek
Article
Endocrinology & Metabolism
Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom
JOURNAL OF DIABETES RESEARCH
(2020)
Editorial Material
Endocrinology & Metabolism
Mark Yorek
JOURNAL OF DIABETES RESEARCH
(2020)
Article
Endocrinology & Metabolism
Alexander Strom, Klaus Strassburger, Martin Schmuck, Hanna Shevalye, Eric Davidson, Fariba Zivehe, Gidon Boenhof, Rudolph Reimer, Bengt-Frederik Belgardt, Thomas Fleming, Barbara Biermann, Volker Burkart, Karsten Muessig, Julia Szendroedi, Mark A. Yorek, Ellen Fritsche, Peter P. Nawroth, Michael Roden, Dan Ziegler
Summary: The lack of effective treatments for diabetic sensorimotor polyneuropathy has led to the search for new strategies to combat or prevent the condition. This study found that reduced serum magnesium levels and increased plasma methylglyoxal levels were associated with the development of the condition. Additionally, the interaction between magnesium and methylglyoxal played a role in methylglyoxal-dependent nerve dysfunction, with magnesium supplementation showing a neuroprotective effect.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Lawrence Coppey, Alexander Obrosov, Hanna Shevalye, Eric Davidson, William Paradee, Mark A. Yorek
Summary: The study found that treating type 2 diabetic mice with menhaden oil can improve deficits related to diabetic peripheral neuropathy (DPN), with more significant effects observed in transgenic mice, indicating a potential protective role of menhaden oil in DPN. Targeting pathways to increase the production of anti-inflammatory metabolites of omega-3 PUFA may be an effective approach in developing treatments for DPN.
JOURNAL OF DIABETES RESEARCH
(2021)
Review
Nutrition & Dietetics
Scott M. Ebert, Blake B. Rasmussen, Andrew R. Judge, Sarah M. Judge, Lars Larsson, Ronald C. Wek, Tracy G. Anthony, George R. Marcotte, Matthew J. Miller, Mark A. Yorek, Adrian Vella, Elena Volpi, Jennifer Stern, Matthew D. Strub, Zachary Ryan, John J. Talley, Christopher M. Adams
Summary: Activating transcription factor 4 (ATF4) is a multifunctional protein that regulates transcription and is involved in various cellular responses. Most of our knowledge about ATF4 comes from studies conducted in cultured cells, with limited understanding of its in vivo role. This review provides an overview of the basic biology of ATF4 and focuses on its role in mammalian skeletal muscle fibers.
JOURNAL OF NUTRITION
(2022)
Review
Endocrinology & Metabolism
Mark Yorek
Summary: Animal models have played a crucial role in exploring the etiology and potential treatments for diabetic peripheral neuropathy. However, the complexity of the disease and the differences between type 1 and type 2 diabetes pose challenges in successful translation of treatment strategies from animal studies to human clinical trials. Various mechanisms have been identified, including hyperglycemia, insulin resistance, hyperlipidemia, oxidative and inflammatory stress, dysregulation of protein kinase C and hexosamine pathways, and decreased neurotrophic support.
CURRENT DIABETES REVIEWS
(2022)
Article
Endocrinology & Metabolism
Lawrence Coppey, Eric Davidson, Hanna Shevalye, Alexander Obrosov, Michael Torres, Mark A. Yorek
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Physiology
Daniel W. Nuno, Lawrence J. Coppey, Mark A. Yorek, Kathryn G. Lamping
PHYSIOLOGICAL REPORTS
(2018)
Review
Endocrinology & Metabolism
Mark Anthony Yorek
CURRENT DIABETES REVIEWS
(2018)