期刊
CURRENT DRUG METABOLISM
卷 14, 期 8, 页码 910-920出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920021131400113
关键词
Absorption; CNT; distribution; drug release; excretion; intracellular internalization; metabolism; tumor targeting
资金
- National Natural Science Foundation of China [81071273, 31170929, 81201211]
- Foundation for the Author of National Excellent Doctoral Dissertation of China [FANEDD 200977]
- Funding for Distinguished Young Scientists in Sichuan [2010JQ0066]
- Ministry of Education of China [20110181120071]
Carbon nanotubes (CNT) are allotropes of carbon with a cylindrical nanostructure. They have recently aroused great interests as drug carriers, but their pharmacokinetic profiles which determine their potentials in clinical application are yet to be fully understood. Therefore, this overview attempts to outline the processes of absorption, distribution, metabolism and excretion (ADME) that govern the pharmacokinetics of CNT. In addition, the molecular mechanisms of intracellular internalization and drug release are also discussed.
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