Article
Pharmacology & Pharmacy
Nasrul Wathoni, Lisa Efriani Puluhulawa, I. Made Joni, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Tiana Milanda, Dolih Gozali
Summary: Lung cancer, the second most common type of cancer, has the highest mortality rate. Nanoparticle technology is being developed for lung cancer therapies, but specific ligands are needed to enhance drug delivery precision. Monoclonal antibodies can actively target nanoparticles to cancer cells, but they have drawbacks. Formulating antibodies in nanoparticles can minimize these drawbacks and enhance drug targeting.
Article
Biochemical Research Methods
Karthika J. Kadassery, A. Paden King, Stanley Fayn, Kwamena E. Baidoo, Samantha N. MacMillan, Freddy E. Escorcia, Justin J. Wilson
Summary: Actinium-225 is a promising radionuclide for targeted alpha therapy (TAT). This study investigates the use of two rigid variants of the H-2 macropa chelator for Ac-225 TAT. The results demonstrate the potential of H(2)BZmacropa as a bifunctional chelator for Ac-225 radiopharmaceuticals.
BIOCONJUGATE CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Reena Gupta, Jitendra Gupta, Abhishek Pathak
Summary: Cancer is a deadly disease that causes many deaths. Drug targeting and managing drug delivery systems, such as liposomes, have been developed to improve drug specificity and reduce side effects. Immunoliposomes, created by combining monoclonal antibodies with liposomes, are a leading technique for targeted delivery. Various strategies, such as thiolation and amide bonds, are used for cancer-specific targeting. Stimulus-responsive immunoliposomes have been developed to regulate drug release and have applications in vaccination, cancer therapeutics, and immune response stimulation.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francesca Oltolina, Maria del Carmen Santaella Escolano, Ylenia Jabalera, Maria Prat, Concepcion Jimenez Lopez
Summary: This study demonstrates the concept of a promising drug carrier for cancer therapy based on targeted magnetic liposomes, which can achieve localized chemotherapy on target cancer cells using specific antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xiqi Peng, Songsong Tang, Daitian Tang, Dewang Zhou, Yangyang Li, Qiwei Chen, Fangchen Wan, Heather Lukas, Hong Han, Xueji Zhang, Wei Gao, Song Wu
Summary: Researchers have developed an autonomous nanorobot capable of delivering drugs to mitochondria, which leads to improved anticancer effects and suppression of cancer cell metastasis. The nanorobot utilizes catalytic activity to decompose hydrogen peroxide in tumor cells, allowing effective delivery of drugs to mitochondria. In vivo experiments demonstrate the effectiveness of the nanorobot in subcutaneous and orthotopic breast tumor models. This breakthrough introduces a new era of precision therapy with organelle-level resolution.
Review
Chemistry, Multidisciplinary
Salma B. Abdelbaky, Mayar Tarek Ibrahim, Hebatallah Samy, Menatalla Mohamed, Hebatallah Mohamed, Mahmoud Mustafa, Moustafa M. Abdelaziz, M. Laird Forrest, Islam A. Khalil
Summary: Cancer immunotherapy has shown promise in eradicating cancer cells and overcoming multidrug resistance with fewer side effects compared to traditional cytotoxic therapies, utilizing agents such as checkpoint inhibitors and monoclonal antibodies to help immune cells target tumor cells. However, concerns remain around off-target side effects and poor pharmacokinetics in immunotherapeutics. Nanomedicine offers potential solutions by improving drug delivery, release control, and pharmacokinetic profiles, enhancing therapeutic outcomes and minimizing side effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Davide Busato, Monica Mossenta, Michele Dal Bo, Paolo Macor, Giuseppe Toffoli
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, with low survival rates and a majority of patients already in advanced stages. Current treatment options for PDAC are limited, highlighting the need for targeted therapies that can differentiate between cancerous and non-cancerous cells. Antibody-based immunotherapies and antibody-conjugated nanoparticle-based targeted therapies, targeting specific tumor-associated antigens (TAA), show promise as potential innovative treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yixin Wang, Wen Li, Zhaoting Li, Fanyi Mo, Yu Chen, Mari Iida, Deric L. Wheeler, Quanyin Hu
Summary: Immune checkpoint inhibitors (ICIs) have potential in treating various tumors by reinvigorating T cells. Researchers propose a delivery strategy to enhance tumor-selective ICI accumulation by utilizing platelet responsiveness to coagulation signals. A fused protein tTF-RGD targets tumor blood vessels and initiates local coagulation, attracting platelets conjugated with anti-PD-1 antibodies to release them for improved immunotherapy. The study also demonstrates enhanced accumulation and efficacy of chemotherapeutics using platelet membrane-coated nanoparticles. This versatile platform utilizes platelet responsiveness for improved local accumulation of ICIs and chemodrugs.
Review
Chemistry, Multidisciplinary
Adilet Beishenaliev, Yean Leng Loke, Sook Jing Goh, Hui Nee Geo, Malar Mugila, Misni Misran, Lip Yong Chung, Lik Voon Kiew, Steve Roffler, Yin Yin Teo
Summary: Monospecific antibodies have limitations in delivering drugs to tumors with multiple epitopes, while bispecific antibodies provide a promising alternative by simultaneously targeting two distinct antigens or epitopes. This review discusses the roles of bispecific antibodies in enhancing the internalization and intracellular trafficking of drug-conjugated antibodies and facilitating the delivery of drug-encapsulating nanoconstructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Supriti Ghosh, Pradyumna Jayaram, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
Summary: Cervical cancer is a prevalent cancer among women worldwide, but it can be preventable. Nanotechnology has provided a solution for targeted drug delivery due to the limitations of conventional chemotherapeutics. This review summarizes various drug delivery approaches and nanocarriers, their advantages, limitations, and potential applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Health Care Sciences & Services
Sean Harrop, Chathuri Abeyakoon, Carrie Van der Weyden, H. Miles Prince
Summary: T-cell lymphomas, rare and unsatisfactorily treated, have shown progress in targeted therapies due to advancements in understanding T-cell lymphogenesis pathways and identifying therapeutic targets. New treatments include antibody-based, small molecule inhibitors, and immune-based therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Zongyi Wei, Yuxin Zhou, Rongjie Wang, Jin Wang, Zhenhua Chen
Summary: Undesirable side effects and multidrug tolerance are major challenges in conventional chemotherapy for cancer treatment. Targeted drug delivery using aptamers as smart ligands can enhance drug accumulation at the target site and minimize toxicity to normal tissues and cells. Aptamers have high target affinity and specificity, making them attractive ligands for targeted drug delivery. This article reviews the application of aptamers in cancer therapy, focusing on their use as smart ligands, conjugation with nanocarriers, targeting strategies for the tumor microenvironment, and specific aptamers for crucial cancer biomarkers.
Review
Chemistry, Multidisciplinary
Palmira Alessia Cavallaro, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, Antonella Leggio
Summary: Breast cancer is a common and deadly disease, and overexpression of HER2 is a major contributing factor. This review provides an overview of the diagnosis and treatment approaches for HER2-positive breast cancer in the past decade. Antibodies and peptides are explored as targeting strategies, with nanotechnology offering potential solutions to current clinical challenges in breast cancer imaging, targeting, and therapy.
Article
Chemistry, Multidisciplinary
Faustine D'Orchymont, Jason P. Holland
Summary: In this study, a unique rotaxane-antibody conjugate was developed for PET imaging and quantification of specific tumor receptors. The experimental results showed that the rotaxane-radiotracer has improved pharmacokinetic properties and reduced radiation exposure to critical organs.
Article
Oncology
Sai Kiran Sharma, Kyeara N. Mack, Alessandra Piersigilli, Jacob Pourat, Kimberly J. Edwards, Outi Keinanen, Maria S. Jiao, Huiyong Zhao, Brandy White, Cory L. Brooks, Elisa de Stanchina, Madi R. Madiyalakan, Michael A. Hollingsworth, Prakash Radhakrishnan, Jason S. Lewis, Brian M. Zeglis
Summary: This study validated the binding ability of a novel monoclonal antibody AR9.6 to MUC16, which can abrogate pro-oncogenic signaling and provide therapeutic response. The in vitro and in vivo experiments confirmed the binding of AR9.6 to ovarian and pancreatic cancer cells, as well as the uptake of radioactivity in lymph nodes with high MUC16 expression.
CLINICAL CANCER RESEARCH
(2022)