Review
Biochemistry & Molecular Biology
Aurelia Scarano, Barbara Laddomada, Federica Blando, Stefania De Santis, Giulio Verna, Marcello Chieppa, Angelo Santino
Summary: This article examines the effects of dietary polyphenols on human health, focusing on their antioxidant properties and chelating abilities. It explores the importance of polyphenols and their iron-binding abilities in inflammatory/immunomodulatory responses, with specific attention to macrophages and dendritic cells, as well as their impact on gut microbiota. The article also highlights the need for further investigation into the polyphenol-iron metabolism-inflammatory responses axis and the polyphenol-iron availability-gut microbiota relationship to prevent or counteract pathological conditions.
Article
Food Science & Technology
Besim Ozyel, Gwenaelle Le Gall, Paul W. Needs, Paul A. Kroon
Summary: The study shows that quercetin can alter the balance of endothelial cell metabolites towards a less inflamed phenotype, both alone and in the presence of pro-inflammatory stimuli. Quercetin inhibits specific enzyme activities, reducing the harmful effects of high glucose or inflammation on endothelial cells.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Brandon Aguiar, Helena Carmo, Jorge Garrido, Jose M. Sousa Lobo, Isabel F. Almeida
Summary: This study evaluated the photoreactivity and phototoxicity of five phenolic antioxidants commonly used in cosmetic products. Results showed that although these compounds were able to absorb UV radiation, they did not display any phototoxic potential.
Article
Engineering, Environmental
Xiangrui Wang, Wen-Xiong Wang
Summary: This study revealed the underlying mechanisms of high Cu toxicity under Fe deficiency and highlighted the critical role of modulation of Cu metabolism in phytoplankton.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hui-Min Liu, Ming-Yan Cheng, Meng-Han Xun, Zhi-Wei Zhao, Yun Zhang, Wei Tang, Jun Cheng, Jia Ni, Wei Wang
Summary: As the body's greatest defense organ, the skin is exposed to internal and external stressors that generate reactive oxygen species (ROS), leading to oxidative stress, skin cellular senescence, inflammation, and cancer. Oxidative stress-induced skin cellular senescence, inflammation, and cancer can occur through two main mechanisms: direct degradation of essential biological macromolecules by ROS, and modulation of signaling pathways affecting cytokine release and enzyme expression. Plant polyphenols, such as curcumin, catechins, resveratrol, quercetin, ellagic acid, and procyanidins, have therapeutic potential as natural antioxidants. The delivery of plant polyphenols to the skin and current clinical research on polyphenols, especially curcumin, are summarized, providing a theoretical foundation for future clinical research and the development of pharmaceuticals and cosmetics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Agnese Ragno, Marika Cordaro, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Francesca Marino Merlo, Antonella Smeriglio, Daniela Impellizzeri, Salvatore Cuzzocrea, Giuseppina Mandalari, Rosanna Di Paola
Summary: The study evaluated the antioxidant and anti-inflammatory effects of almond skin extract (ASE) and found that it inhibited the formation of ROS and apoptosis in vitro, and restored tissue changes and decreased inflammation in an in vivo model. The mechanisms of action could be related to the inhibition of the pro-inflammatory nuclear factor NF-κB and activation of the Nrf2 antioxidant pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Karolina Jakubczyk, Aleksandra Tuchowska, Katarzyna Janda-Milczarek
Summary: Hydrolates, by-products of plant hydrodistillation, have high antioxidant potential depending on plant species, origin, plant part, and preservation method. The study demonstrates the wide application of hydrosols in cosmetics and their potential value in skincare and agri-food industry.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Veterinary Sciences
Marcella Massimini, Elena Dalle Vedove, Benedetta Bachetti, Francesco Di Pierro, Cataldo Ribecco, Claudio D'Addario, Mariangela Pucci
Summary: By using a novel in vitro model of AD, researchers attempted to reverse the altered transcriptional regulation of key genes associated with canine atopic dermatitis using a nutraceutical mixture. The results showed a significant downregulation of gene expression in inflamed cells and an increase in DNA methylation at specific CpG sites, laying the groundwork for potential use in veterinary medicine and deeper understanding of the mechanisms of action.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Victoria Silva, Hector Oreliana Fernandes Faria, Celso Pereira Batista Sousa-Filho, Jose Fernando Rinaldi de Alvarenga, Jarlei Fiamoncini, Rosemari Otton
Summary: Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive accumulation of triglycerides in hepatocytes and is considered the leading cause of chronic liver disease. It is closely associated with obesity, type 2 diabetes, hyperlipidemia, and hypertension. This study investigates the effects of green tea (GT) on MAFLD and shows that GT has beneficial effects on the liver phenotype and gene expression involved in lipogenesis, regardless of housing temperature.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Anna-Lena Mueller, Aranka Brockmueller, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Tendinitis is a common tendon disease caused by mechanical overuse, injuries, drug abuse, and lifestyle factors. Nuclear factor kappa B is an important pro-inflammatory transcription factor that regulates genes involved in inflammation, degradation, and cell death. Plant-derived nutraceuticals can target multiple signaling pathways and suppress inflammation in tendinitis.
Article
Nutrition & Dietetics
Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjao, Rosemari Otton
Summary: This study aims to investigate the immune cell population in the subcutaneous and epididymal white adipose tissue (WAT) of obese mice, as well as the effects of green tea. The results suggest that a high-fat diet and thermoneutrality can induce chronic inflammation and insulin resistance. However, green tea can prevent weight gain, inflammation, and tissue fibrosis, while maintaining a similar immune cell profile to that of lean mice.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Plant Sciences
Jozaa Z. ALTamimi, Ghedeir M. Alshammari, Nora A. AlFaris, Reham Alagal, Dalal H. Aljabryn, Norah A. Albekairi, Mahmoud Ahmad Alkhateeb, Mohammed Abdo Yahya
Summary: Ellagic acid (EA) has anti-steatotic effects in streptozotocin-induced type 1 diabetes mellitus in rats, potentially mediated through the AMPK signaling pathway. It reduces blood glucose levels, increases insulin levels, prevents hepatic lipid accumulation, and decreases levels of triglycerides, cholesterol, and free fatty acids. It also reduces oxidative stress and inflammation in the liver.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huan Chen, Ying Li, Jinrui Wang, Tingting Zheng, Chenyang Wu, Mengyao Cui, Yifan Feng, Hanyi Ye, Zhengqi Dong, Yunjie Dang
Summary: The pathogenesis of ulcerative colitis (UC) is closely related to inflammation, oxidative stress, and gut microbiota imbalance. This study explored the antioxidant activity and underlying mechanisms of various plant polyphenols, such as gallic acid, proanthocyanidin, ellagic acid, and tannic acid. The results showed that polyphenols with more phenolic hydroxyl groups exhibited stronger antioxidant activity. Moreover, these polyphenols effectively ameliorated UC symptoms and pathological progression in mice by reducing inflammatory cytokine levels, repairing the intestinal barrier, and regulating the intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Zhebin Chen, Dasong Liu, Xue Tang, Ying Cui, Wei Hu, Joe M. Regenstein, Peng Zhou
Summary: Sea cucumber enzymatic hydrolysates (SCEH) can inhibit osteoclast generation via the NF-kappa B pathway, reduce inflammation related to osteoporosis, and improve bone metabolism, thereby increasing bone density and relieving osteoporosis.
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, Mark S. Kindy
Summary: Plant-based nutritional supplementation can attenuate the progression of acute and chronic disorders by improving inflammatory responses and maintaining stable neurotransmitter levels. Experimentally induced inflammation by LPS affects glucose, insulin tolerance, and neurotransmitter levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Vladimir Kostyuk, Alla Potapovich, Ahmed R. Albuhaydar, Wolfgang Mayer, Chiara De Luca, Liudmila Korkina
REJUVENATION RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Saveria Pastore, Daniela Lulli, Paolo Fidanza, Alla I. Potapovich, Vladimir A. Kostyuk, Chiara De Luca, Elena Mikhal'Chik, Liudmila G. Korkina
ANTIOXIDANTS & REDOX SIGNALING
(2012)
Review
Biochemistry & Molecular Biology
Liudmila Korkina, Vladimir Kostyuk
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2012)
Article
Pharmacology & Pharmacy
Vladimir A. Kostyuk, Alla I. Potapovich, Tatyana O. Suhan, Chiara de Luca, Liudmila G. Korkina
EUROPEAN JOURNAL OF PHARMACOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Saveria Pastore, Valentina Mariani, Daniela Lulli, Emanuela Gubinelli, Desanka Raskovic, Serena Mariani, Andrea Stancato, Chiara De Luca, Alessandra Pecorelli, Giuseppe Valacchi, Alla I. Potapovich, Vladimir A. Kostyuk, Liudmila G. Korkina
FREE RADICAL RESEARCH
(2011)
Article
Cell Biology
Alla I. Potapovich, Vladimir A. Kostyuk, Tatyana V. Kostyuk, Chiara de Luca, Liudmila G. Korkina
INFLAMMATION RESEARCH
(2013)
Article
Dermatology
Saveria Pastore, Daniela Lulli, Alla I. Potapovich, Paolo Fidanza, Vladimir A. Kostyuk, Elena Dellambra, Chiara De Luca, Riccardo Maurelli, Liudmila G. Korkina
JOURNAL OF DERMATOLOGICAL SCIENCE
(2011)
Article
Plant Sciences
Milen Georgiev, Saveria Pastore, Daniela Lulli, Kalina Alipieva, Vladimir Kostyuk, Alla Potapovich, Mariangela Panetta, Liudmila Korkina
JOURNAL OF ETHNOPHARMACOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Saveria Pastore, Daniela Lulli, Antonia Pascarella, Riccardo Maurelli, Elena Dellambra, Alla Potapovich, Vladimir Kostyuk, Chiara De Luca, Liudmila Korkina
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2012)
Article
Multidisciplinary Sciences
Vladimir Kostyuk, Alla Potapovich, Andrea Stancato, Chiara De Luca, Daniela Lulli, Saveria Pastore, Liudmila Korkina
Article
Pharmacology & Pharmacy
Alla I. Potapovich, Daniela Lulli, Paolo Fidanza, Vladimir A. Kostyuk, Chiara De Luca, Saveria Pastore, Liudmila G. Korkina
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2011)
Article
Geriatrics & Gerontology
Alla I. I. Potapovich, Tatyana V. V. Kostyuk, Tatyana V. V. Shman, Tatyana I. I. Ermilova, Tatyana G. G. Shutava, Vladimir A. A. Kostyuk
Summary: This study investigated the effects of plant polyphenolic compounds (PPs) on the responses of human HaCaT keratinocytes to UV-C radiation. The results showed that PPs added immediately after UV-C exposure had a cytoprotective effect, with acacetin being the most effective. Furthermore, PPs were found to reduce DNA damage in the nuclei of keratinocytes exposed to UV-C.
REJUVENATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Alla I. I. Potapovich, Tatyana V. V. Kostyuk, Olga V. V. Ishutina, Tatsiana G. G. Shutava, Vladimir A. A. Kostyuk
Summary: Due to poor water solubility of plant polyphenols, their bioavailability is low. To overcome this limitation, polymeric materials can be used to coat drug molecules with multiple layers. Microcrystals of quercetin and resveratrol coated with (PAH/PSS)(4) or (CH/DexS)(4) shell were prepared. UV-C induced damage to human HaCaT keratinocytes was evaluated by treating cells with native and particulate polyphenols. The results showed that both native and particulate polyphenols increased cell viability after UV-C exposure in a dose-dependent manner, with particulate quercetin showing a more pronounced effect. Quercetin coated with (CH/DexS)(4) shell effectively reduced DNA lesions in keratinocyte nuclei, while both native and particulate resveratrol were ineffective against DNA damage. Quercetin enhances cell survival and DNA repair capacity, with the coating of (CH/DexS)(4) shell further enhancing its impact on DNA repair.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alla Potapovich, Vladimir Kostyuk
Summary: Research on ultraweak photon emission (UPE) in living organisms dates back to the 1920s, with the discovery of mitogenetic radiation (MGR) by Russian biologist A. Gurwitsch. While there have been numerous studies confirming the existence of permanent biophoton emission and intercellular electromagnetic communication, the significance of MGR has been a topic of debate. New evidence suggests that non-chemical signals can trigger biological cellular responses in a synchronous manner.
RESULTS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
V. A. Kostyuk, A. I. Potapovich, D. Lulli, A. Stancato, C. De Luca, S. Pastore, L. Korkina
CURRENT MEDICINAL CHEMISTRY
(2013)