Review
Biochemistry & Molecular Biology
Stephanie M. Kereliuk, Vernon W. Dolinsky
Summary: Globally, cardiovascular disease remains the leading cause of death, and the increasing cardiovascular risk factors among youth, such as obesity, diabetes, and hypertension, contribute to the development of earlier and more severe cardiovascular disease. Recent evidence suggests that maternal obesity and diabetes during pregnancy have lifelong effects on cardiovascular risk factors and heart disease development in the offspring, although the mechanisms for these observations are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Long T. Nguyen, Carol A. Pollock, Sonia Saad
Summary: The developmental programming hypothesis suggests that adverse environmental insults during critical developmental periods increase the risk of diseases in later life. Kidneys are susceptible to such insults, particularly due to peri-gestational nutrition, which affects kidney development and metabolism. Recent studies have identified oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes as potential novel pathways for therapeutic intervention.
Article
Public, Environmental & Occupational Health
Sarah A. Mustillo, Miao Li, Patricia Morton, Kenneth F. Ferraro
Summary: This study found that negative childhood experiences have a direct or indirect impact on BMI and obesity in older adults, with this influence being moderated by adult factors such as socioeconomic status, depressive symptoms, and physical activity.
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR
(2021)
Review
Physiology
Daniel J. Hoffman, Theresa L. Powell, Emily S. Barrett, Daniel B. Hardy
Summary: Nearly 2 billion adults worldwide are overweight, with over half classified as obese, and nearly one-third of global children experience poor growth and development. The global epidemic of obesity and double burden of malnutrition, where overweight coexists with underweight and micronutrient deficiencies, poses a significant challenge to human health. Understanding the developmental origins of health and disease (DOHaD) is crucial in addressing the global issues of obesity and chronic diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Psychology, Developmental
Ellen Verhoef, Chin Yang Shapland, Simon E. Fisher, Philip S. Dale, Beate St Pourcain
Summary: The heritability of language and literacy skills increases from early-childhood to adolescence, with little support for the emergence of novel genetic sources during mid-childhood or early adolescence. Instead, genetic factors of early-childhood vocabulary, especially those unique to receptive skills, were amplified and represented the majority of genetic variance underlying many of these later complex skills.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Review
Public, Environmental & Occupational Health
Siyu Zhu, Shiyi Shan, Wen Liu, Shuting Li, Leying Hou, Xuanyin Huang, Yi Liu, Qian Yi, Weidi Sun, Kun Tang, Davies Adeloye, Igor Rudan, Peige Song
Summary: The study found that there is a certain association between adverse childhood experiences and adult diabetes, especially for those who have experienced economic adversity, physical abuse, sexual abuse, verbal abuse, and incarceration.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Nutrition & Dietetics
Wenxiu Wang, Jun Lv, Canqing Yu, Yu Guo, Pei Pei, Zhenhuang Zhuang, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Xianping Wu, Junshi Chen, Zhengming Chen, Robert Clarke, Tao Huang, Liming Li
Summary: Genetic predisposition to low birth weight and childhood obesity is associated with higher risk of adult T2D, but this risk can be reduced in adulthood by adherence to a healthy lifestyle, especially among those with high genetic risk of childhood obesity.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Hypertension is a significant global disease burden and can originate in early life. Melatonin, a hormone with multifaceted biological functions, plays important roles in pregnancy, fetal development, and blood pressure regulation. Early melatonin therapy as a reprogramming strategy can protect against the early life origins of hypertension.
Review
Endocrinology & Metabolism
Mostafa Salama, Babu Balagopal, Ilene Fennoy, Seema Kumar
Summary: This mini-review provides a brief summary of the pathophysiology of childhood obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk. It also reviews recent data on lifestyle interventions, medications, and metabolic surgery for obesity, T2DM, and CVD risk factors. Childhood obesity is influenced by genetic, physiological, environmental, and socioeconomic factors. There is a need for a comprehensive approach to detecting, monitoring, and managing childhood obesity and its metabolic consequences.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Otilia Perichart-Perera, Ameyalli M. Rodriguez-Cano, Isabel Gonzalez-Ludlow, Carolina Rodriguez-Hernander, Blanca Suarez-Rico, Enrique Reyes-Munoz, Gicela Villalobos-Alcazar, Guadalupe Estrada-Gutierrez
Summary: This study evaluates the association between maternal obesity, gestational diabetes, and birth weight with early infancy fat-mass accretion. The findings show that infant weight and being female are positively associated with fat-mass accretion, while maternal obesity, medication use, and exclusive breastfeeding are not. Gestational diabetes appears to affect early adiposity accretion, independent of excessive fetal growth, and being small for gestational age is associated with higher fat-mass accretion in early infancy.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Carla K. Miller, Haikady N. Nagaraja, Jennifer Cheavens, Kentaro Fujita, Sophie Lazarus
Summary: The impact of an adaptive rescue intervention for slow responders was evaluated in this study. The results showed significant improvement in multiple outcomes for the standard intervention compared to the adaptive intervention. However, participants in the adaptive intervention group also experienced significant reductions in weight loss and blood glucose. The study also found that weight loss at week 5 significantly predicted weight loss at 4 months.
Article
Nutrition & Dietetics
Louise R. Jones, Pauline M. Emmett, Nicholas P. Hays, Yassaman Shahkhalili, Caroline M. Taylor
Summary: The study aimed to replicate a previous finding that low fat intake in early childhood was linked to increased adiposity in adulthood, but the results did not support this. Instead, a positive association was found between high fat intake at 18 months and fat mass in boys at 9 years, with no association in girls. Additionally, fat intake was positively correlated with serum leptin concentration in boys, but not in girls.
Article
Environmental Sciences
Charles Saylor, Ashley J. Malin, Marcela Tamayo-Ortiz, Alejandra Cantoral, Chitra Amarasiriwardena, Guadalupe Estrada-Gutierrez, Mari Cruz Tolentino, Ivan Pantic, Robert O. Wright, Martha M. Tellez-Rojo, Alison P. Sanders
Summary: The study found that low-level fluoride exposure in early childhood is not associated with renal function in preadolescence. Although there may be a negative association between fluoride exposure and kidney function in obese children, there is no evidence of sex-specific effects or effect modification by BMI status. Longitudinal follow-up in this cohort and others is needed for further investigation.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biology
Anup Malani, Elizabeth A. Archie, Stacy Rosenbaum
Summary: In many species, individuals that experience harsh conditions during development have poor health and fitness outcomes in adulthood, compared with peers that do not. Different evolutionary hypotheses, such as Developmental Constraints (DC) models and Predictive Adaptive Response (PAR) hypotheses, have been proposed to explain these early-life contributions to inequality. This article provides mathematical definitions and proposes a quadratic regression-based statistical test to better distinguish between DC and PAR hypotheses, highlighting the importance of linking verbal and visual models to a formal mathematical treatment in understanding the developmental origins of inequitable adult outcomes.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Anna Otte, Hermann L. Mueller
Summary: Craniopharyngiomas are rare embryonic malformational tumors of low-grade malignancy, often presenting in children with symptoms such as hypothalamic and visual disturbances. Treatment approaches vary based on tumor location, typically involving surgical resection and radiation therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
A. Fortin, R. Rabasa-Lhoret, S. Lemieux, M-E Labonte, V Gingras
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2018)
Article
Nutrition & Dietetics
Veronique Gingras, Sheryl L. Rifas-Shiman, Elsie M. Taveras, Emily Oken, Marie-France Hivert
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2018)
Article
Endocrinology & Metabolism
Ivonne P. M. Derks, Marie-France Hivert, Sheryl L. Rifas-Shiman, Veronique Gingras, Jessica G. Young, Pauline W. Jansen, Emily Oken
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Nutrition & Dietetics
Veronique Gingras, Sheryl L. Rifas-Shiman, Karen M. Switkowski, Emily Oken, Marie-France Hivert
Editorial Material
Cardiac & Cardiovascular Systems
Alvaro Alonso, Madison D. Anderson, Michael P. Bancks, Sherry-Ann Brown, Melissa C. Caughey, Alex R. Chang, Erin Delker, Kathryn Foti, Eronique Gingras, Michael G. Nanna, Alexander C. Razavi, Jewel Scott, Elizabeth Selvin, Catherine Tcheandjieu, Alvin G. Thomas, Ruth-Alma N. Turkson-Ocran, Allison Webel, Deborah R. Young, Bailey M. DeBarmore
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Pediatrics
Veronique Gingras, Izzuddin M. Aris, Sheryl L. Rifas-Shiman, Karen M. Switkowski, Emily Oken, Marie-France Hivert
Article
Nutrition & Dietetics
Karen M. Switkowski, Veronique Gingras, Sheryl L. Rifas-Shiman, Emily Oken
Editorial Material
Cardiac & Cardiovascular Systems
Alexander C. Razavi, Veronique Gingras, Erin D. Michos, Ann Marie Navar, Sherry-Ann Brown, Erin Delker, Kathryn Foti, Stephanie Harrison, Yifei Lu, Jovia L. Nierenberg, Jewel Scott, Olive Tang, Alvin G. Thomas, Ruth-Alma Turkson-Ocran, Amelia Wallace, Mingyu Zhang, Kristie J. Lancaster, Pamela L. Lutsey, Elizabeth Selvin
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Environmental Sciences
Marcia P. Jimenez, Emily Oken, Diane R. Gold, Heike Luttmann-Gibson, Weeberb J. Requia, Sheryl L. Rifas-Shiman, Veronique Gingras, Marie-France Hivert, Eric B. Rimm, Peter James
ENVIRONMENT INTERNATIONAL
(2020)
Article
Nutrition & Dietetics
Veronique Gingras, Karen M. Switkowski, Sheryl L. Rifas-Shiman, Sabrina Faleschini, Emily Oken, Marie-France Hivert
Letter
Neurosciences
Sabrina Faleschini, Sheryl L. Rifas-Shiman, Carmen Monthe-Dreze, Karen M. Switkowski, Veronique Gingras, Wei Perng, Emily Oken, Marie-France Hivert, Henning Tiemeier
BIOLOGICAL PSYCHIATRY
(2021)
Review
Nutrition & Dietetics
Catherine Savard, Stephanie Begin, Veronique Gingras
Summary: This systematic review examines the determinants of eating in the absence of hunger (EAH) among children and adolescents. The review includes studies that explore individual, familial, and environmental factors associated with EAH. The findings suggest that EAH increases with age in childhood, with a greater prevalence in boys compared to girls, and a positive association with adiposity. Genetic factors also seem to influence the development of EAH. However, there is limited research on EAH in adolescence, and the findings for overweight or obesity are inconsistent. Studies on environmental factors are lacking, and more robust longitudinal studies are needed.
Review
Pediatrics
Audrey Nantel, Veronique Gingras
Summary: Many parents do not follow complementary feeding guidelines, leading to negative effects on children's health. There are significant variations in the timing and types of complementary foods introduced globally. Parental characteristics, such as age, education, socio-economic status, and race/ethnicity, play a role in determining feeding practices.
Article
Endocrinology & Metabolism
Veronique Gingras, Katherine Desjardins, Mohamed Raef Smaoui, Valerie Savard, Virginie Messier, Ahmad Haidar, Laurent Legault, Remi Rabasa-Lhoret
ACTA DIABETOLOGICA
(2018)
Review
Endocrinology & Metabolism
Veronique Gingras, Nadine Taleb, Amelie Roy-Fleming, Laurent Legault, Remi Rabasa-Lhoret
DIABETES OBESITY & METABOLISM
(2018)